YJR100C / AIM25

Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR100C / AIM25

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:3.42|P-value:1.35E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.00|P-value:8.13E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.17|P-value:4.27E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:2.98|P-value:7.63E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.23|P-value:3.40E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.07|P-value:5.34E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.05|P-value:6.56E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:2.95|P-value:8.42E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:2.92|P-value:9.44E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.01|P-value:6.82E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.04|P-value:6.98E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.68|P-value:4.02E-7 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.00|P-value:7.90E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.42|P-value:1.32E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.22|P-value:4.46E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.38|P-value:1.64E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.64|P-value:6.46E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.62|P-value:5.65E-7 ID:SGTC_1141|Compound:3253-0389|FD-Score:4.55|P-value:6.53E-7 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.13|P-value:4.29E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-2.95|P-value:9.68E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.12|P-value:4.53E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.96|P-value:8.14E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.24|P-value:3.21E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.26|P-value:2.63E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.20|P-value:4.93E-6 ID:SGTC_1751|Compound:st044839|FD-Score:3.62|P-value:5.86E-5 ID:SGTC_1899|Compound:st063254|FD-Score:-2.98|P-value:8.57E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.13|P-value:5.02E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.12|P-value:5.18E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.34|P-value:2.22E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.24|P-value:2.80E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.57|P-value:8.50E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.98|P-value:7.63E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.19|P-value:3.96E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.52|P-value:9.16E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:5.64|P-value:1.07E-9 ID:SGTC_2804|Compound:7954240|FD-Score:3.06|P-value:5.59E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.40|P-value:1.47E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.01|P-value:1.03E-5 ID:SGTC_3075|Compound:9116269|FD-Score:2.93|P-value:9.01E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.02|P-value:7.43E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.64|P-value:6.38E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.42|P-value:1.35E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.00|P-value:8.13E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.17|P-value:4.27E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:2.98|P-value:7.63E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.23|P-value:3.40E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.07|P-value:5.34E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.05|P-value:6.56E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:2.95|P-value:8.42E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:2.92|P-value:9.44E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.01|P-value:6.82E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.04|P-value:6.98E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.68|P-value:4.02E-7 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.00|P-value:7.90E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.42|P-value:1.32E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.22|P-value:4.46E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.38|P-value:1.64E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.64|P-value:6.46E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.62|P-value:5.65E-7 ID:SGTC_1141|Compound:3253-0389|FD-Score:4.55|P-value:6.53E-7 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.13|P-value:4.29E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-2.95|P-value:9.68E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.12|P-value:4.53E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.96|P-value:8.14E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.24|P-value:3.21E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.26|P-value:2.63E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.20|P-value:4.93E-6 ID:SGTC_1751|Compound:st044839|FD-Score:3.62|P-value:5.86E-5 ID:SGTC_1899|Compound:st063254|FD-Score:-2.98|P-value:8.57E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.13|P-value:5.02E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.12|P-value:5.18E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.34|P-value:2.22E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.24|P-value:2.80E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.57|P-value:8.50E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.98|P-value:7.63E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.19|P-value:3.96E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.52|P-value:9.16E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:5.64|P-value:1.07E-9 ID:SGTC_2804|Compound:7954240|FD-Score:3.06|P-value:5.59E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.40|P-value:1.47E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.01|P-value:1.03E-5 ID:SGTC_3075|Compound:9116269|FD-Score:2.93|P-value:9.01E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.02|P-value:7.43E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.64|P-value:6.38E-5

Top fitness defect scores for YJR100C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2754 granisetron 5.64 64.0 µM 1.07E-9 8 8.51E-9
2 SGTC_1141 3253-0389 4.55 52.6 µM 6.53E-7 4 2.62E-6
3 SGTC_1085 doxorubicin 4.42 7.7 µM 1.32E-6 anthracycline transcription coupled DNA repair 9 4.90E-6
4 SGTC_2989 9073649 4.01 71.4 µM 1.03E-5 37 3.08E-5
5 SGTC_1751 st044839 3.62 27.2 µM 5.86E-5 Golgi 14 1.46E-4
6 SGTC_2690 usnic acid 3.52 100.0 µM 9.16E-5 42 2.18E-4
7 SGTC_63 0099-0242 3.42 26.7 µM 1.35E-4 mitochondrial stress 118 3.09E-4
8 SGTC_2848 9016370 3.40 26.0 µM 1.47E-4 51 3.32E-4
9 SGTC_1131 3454-3128 3.38 32.3 µM 1.64E-4 67 3.67E-4
10 SGTC_1586 deoxycorticosterone acetate 3.26 53.7 µM 2.63E-4 29 5.59E-4
11 SGTC_2303 7774051 3.24 200.0 µM 2.80E-4 44 5.92E-4
12 SGTC_1142 3253-1408 3.13 9.8 µM 4.29E-4 30 8.68E-4
13 SGTC_1181 1222-0449 3.12 220.0 µM 4.53E-4 56 9.12E-4
14 SGTC_358 0075-0058 3.07 9.4 µM 5.34E-4 123 0.00106
15 SGTC_2804 7954240 3.06 19.5 µM 5.59E-4 77 0.00110
16 SGTC_737 1950-0117 3.01 57.9 µM 6.82E-4 57 0.00131
17 SGTC_330 1488-0319 2.98 80.1 µM 7.63E-4 RPP1 & pyrimidine depletion 52 0.00145
18 SGTC_2583 asiatic acid 2.98 100.0 µM 7.63E-4 77 0.00145
19 SGTC_1312 1218-2183 2.96 165.0 µM 8.14E-4 35 0.00154
20 SGTC_597 k018-0003 2.95 82.8 µM 8.42E-4 RNA pol III & RNase P/MRP 44 0.00159

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.98E-14 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.115 2.94E-11 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.111 1.37E-10 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.107 4.80E-10 YJL067W_d YJL067W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.48E-9 YPR025C CCL1 het Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
0.097 2.06E-8 YHR085W IPI1 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene
0.097 2.13E-8 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.093 6.38E-8 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.090 1.84E-7 YOL047C_p YOL047C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.089 2.69E-7 YJL119C_d YJL119C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.16E-7 YNL013C_d YNL013C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
0.087 4.39E-7 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.087 4.67E-7 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.086 6.94E-7 YGR194C XKS1 hom Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
0.083 1.43E-6 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide