HIPHOP chemogenomics database
YJR104C / SOD1 
Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YJR104C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.509 | 6.05E-220 | YMR038C | CCS1 | hom | Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress |
| 0.339 | 1.21E-90 | YPR123C_d | YPR123C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR |
| 0.266 | 1.59E-55 | YPR124W | CTR1 | hom | High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress |
| 0.263 | 5.69E-54 | YMR021C | MAC1 | hom | Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport |
| 0.261 | 3.26E-53 | YJL120W_d | YJL120W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO |
| 0.227 | 1.71E-40 | YML007W | YAP1 | hom | Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
| 0.227 | 1.46E-40 | YGL167C | PMR1 | hom | High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease |
| 0.199 | 2.37E-31 | YMR073C | IRC21 | hom | Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study |
| 0.199 | 2.88E-31 | YOR209C | NPT1 | hom | Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus |
| 0.182 | 2.08E-26 | YHR008C | SOD2 | hom | Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated |
| 0.181 | 4.39E-26 | YPR074C | TKL1 | hom | Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication |
| 0.180 | 9.04E-26 | YJL121C | RPE1 | hom | D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress |
| 0.152 | 8.41E-19 | YGL168W | HUR1 | hom | Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene |
| 0.139 | 5.42E-16 | YGR257C | MTM1 | hom | Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor |
| 0.138 | 1.10E-15 | YBR058C-A | TSC3 | hom | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |