YJR107W_p

Putative lipase

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR107W / YJR107W

Click on Significant Values for Screen Details ID:SGTC_175|Compound:3793-3120|FD-Score:-4.01|P-value:2.47E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:4.22|P-value:7.66E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.09|P-value:9.01E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.77|P-value:5.62E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.77|P-value:5.62E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.03|P-value:1.32E-7 ID:SGTC_1475|Compound:4092-1048|FD-Score:6.46|P-value:2.01E-11 ID:SGTC_1657|Compound:st012939|FD-Score:3.39|P-value:2.61E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.19|P-value:5.31E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.13|P-value:6.62E-4 ID:SGTC_1807|Compound:st050092|FD-Score:4.09|P-value:1.43E-5 ID:SGTC_1867|Compound:st057372|FD-Score:-3.09|P-value:9.05E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.15|P-value:6.23E-4 ID:SGTC_1901|Compound:st060216|FD-Score:4.04|P-value:1.75E-5 ID:SGTC_1908|Compound:st060353|FD-Score:-3.09|P-value:9.01E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.28|P-value:4.54E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.93|P-value:2.89E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.33|P-value:3.16E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.54|P-value:1.42E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.09|P-value:8.94E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.54|P-value:1.73E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.22|P-value:4.83E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.27|P-value:4.06E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.27|P-value:6.10E-6 ID:SGTC_2817|Compound:7995342|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.03|P-value:9.30E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.45|P-value:2.03E-4 ID:SGTC_3182|Compound:9108849|FD-Score:4.07|P-value:1.57E-5 ID:SGTC_3212|Compound:9128307|FD-Score:5.91|P-value:7.55E-10 ID:SGTC_175|Compound:3793-3120|FD-Score:-4.01|P-value:2.47E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:4.22|P-value:7.66E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.09|P-value:9.01E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.77|P-value:5.62E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.77|P-value:5.62E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.03|P-value:1.32E-7 ID:SGTC_1475|Compound:4092-1048|FD-Score:6.46|P-value:2.01E-11 ID:SGTC_1657|Compound:st012939|FD-Score:3.39|P-value:2.61E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.19|P-value:5.31E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.13|P-value:6.62E-4 ID:SGTC_1807|Compound:st050092|FD-Score:4.09|P-value:1.43E-5 ID:SGTC_1867|Compound:st057372|FD-Score:-3.09|P-value:9.05E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.15|P-value:6.23E-4 ID:SGTC_1901|Compound:st060216|FD-Score:4.04|P-value:1.75E-5 ID:SGTC_1908|Compound:st060353|FD-Score:-3.09|P-value:9.01E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.28|P-value:4.54E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.93|P-value:2.89E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.33|P-value:3.16E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.54|P-value:1.42E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.09|P-value:8.94E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.54|P-value:1.73E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.22|P-value:4.83E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.27|P-value:4.06E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.27|P-value:6.10E-6 ID:SGTC_2817|Compound:7995342|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.03|P-value:9.30E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.45|P-value:2.03E-4 ID:SGTC_3182|Compound:9108849|FD-Score:4.07|P-value:1.57E-5 ID:SGTC_3212|Compound:9128307|FD-Score:5.91|P-value:7.55E-10

Top fitness defect scores for YJR107W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1475 4092-1048 6.46 11.7 µM 2.01E-11 plasma membrane duress 9 5.13E-11
2 SGTC_3212 9128307 5.91 49.5 µM 7.55E-10 15 1.68E-9
3 SGTC_1241 0364-0022 5.03 50.8 µM 1.32E-7 ERG2 14 2.41E-7
4 SGTC_2798 7813637 4.27 45.5 µM 6.10E-6 22 9.61E-6
5 SGTC_787 4152-0075 4.22 138.0 µM 7.66E-6 19 1.20E-5
6 SGTC_1807 st050092 4.09 58.9 µM 1.43E-5 60S ribosome export 11 2.18E-5
7 SGTC_3182 9108849 4.07 49.5 µM 1.57E-5 RPP1 & pyrimidine depletion 12 2.38E-5
8 SGTC_1901 st060216 4.04 58.6 µM 1.75E-5 21 2.65E-5
9 SGTC_2002 4023503 3.93 131.0 µM 2.89E-5 mitochondrial processes 31 4.29E-5
10 SGTC_907 3448-6986 3.77 75.5 µM 5.62E-5 32 8.13E-5
11 SGTC_1073 triclabendazole 3.77 3.1 µM 5.62E-5 31 8.13E-5
12 SGTC_2817 7995342 3.59 71.4 µM 1.17E-4 34 1.65E-4
13 SGTC_2345 9052315 3.54 157.4 µM 1.42E-4 30 1.98E-4
14 SGTC_3134 9127454 3.45 49.5 µM 2.03E-4 21 2.80E-4
15 SGTC_1657 st012939 3.39 43.4 µM 2.61E-4 28 3.55E-4
16 SGTC_2310 7668677 3.33 200.0 µM 3.16E-4 61 4.27E-4
17 SGTC_2621 lithochol-11-enic acid 3.27 100.0 µM 4.06E-4 58 5.44E-4
18 SGTC_2414 st077232 3.22 92.9 µM 4.83E-4 47 6.43E-4
19 SGTC_1728 st035614 3.19 33.8 µM 5.31E-4 95 7.04E-4
20 SGTC_1900 st060200 3.15 72.8 µM 6.23E-4 51 8.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 8.08E-22 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.138 9.94E-16 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.119 4.93E-12 YOR350C MNE1 hom Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA
0.110 1.92E-10 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.100 7.49E-9 YBR024W SCO2 hom Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.097 1.60E-8 YHR130C_d YHR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.52E-8 YOR194C TOA1 het TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA
0.092 1.02E-7 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.092 1.05E-7 YNL304W YPT11 hom Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells
0.090 1.52E-7 YOR055W_d YOR055W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.19E-7 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.088 3.12E-7 YDR241W_d BUD26_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.088 3.62E-7 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.084 1.19E-6 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.082 1.76E-6 YBR206W_d YBR206W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3