HIPHOP chemogenomics database

YJR107W_p

Putative lipase

Zygosity: Homozygous strain

fixedexpanded
Profile for YJR107W / YJR107W

Click on Significant Values for Screen Details

Top fitness defect scores for YJR107W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1475	4092-1048	6.46	11.7 µM	2.01E-11	plasma membrane duress	9	5.13E-11
2	SGTC_3212	9128307	5.91	49.5 µM	7.55E-10		15	1.68E-9
3	SGTC_1241	0364-0022	5.03	50.8 µM	1.32E-7	ERG2	14	2.41E-7
4	SGTC_2798	7813637	4.27	45.5 µM	6.10E-6		22	9.61E-6
5	SGTC_787	4152-0075	4.22	138.0 µM	7.66E-6		19	1.20E-5
6	SGTC_1807	st050092	4.09	58.9 µM	1.43E-5	60S ribosome export	11	2.18E-5
7	SGTC_3182	9108849	4.07	49.5 µM	1.57E-5	RPP1 & pyrimidine depletion	12	2.38E-5
8	SGTC_1901	st060216	4.04	58.6 µM	1.75E-5		21	2.65E-5
9	SGTC_2002	4023503	3.93	131.0 µM	2.89E-5	mitochondrial processes	31	4.29E-5
10	SGTC_907	3448-6986	3.77	75.5 µM	5.62E-5		32	8.13E-5
11	SGTC_1073	triclabendazole	3.77	3.1 µM	5.62E-5		31	8.13E-5
12	SGTC_2817	7995342	3.59	71.4 µM	1.17E-4		34	1.65E-4
13	SGTC_2345	9052315	3.54	157.4 µM	1.42E-4		30	1.98E-4
14	SGTC_3134	9127454	3.45	49.5 µM	2.03E-4		21	2.80E-4
15	SGTC_1657	st012939	3.39	43.4 µM	2.61E-4		28	3.55E-4
16	SGTC_2310	7668677	3.33	200.0 µM	3.16E-4		61	4.27E-4
17	SGTC_2621	lithochol-11-enic acid	3.27	100.0 µM	4.06E-4		58	5.44E-4
18	SGTC_2414	st077232	3.22	92.9 µM	4.83E-4		47	6.43E-4
19	SGTC_1728	st035614	3.19	33.8 µM	5.31E-4		95	7.04E-4
20	SGTC_1900	st060200	3.15	72.8 µM	6.23E-4		51	8.21E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.165	8.08E-22	YHL003C	LAG1	hom	Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.138	9.94E-16	YPL167C	REV3	hom	Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.119	4.93E-12	YOR350C	MNE1	hom	Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA
0.110	1.92E-10	YOL122C	SMF1	hom	Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.100	7.49E-9	YBR024W	SCO2	hom	Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.097	1.60E-8	YHR130C_d	YHR130C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095	3.52E-8	YOR194C	TOA1	het	TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA
0.092	1.02E-7	YGL131C	SNT2	hom	DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.092	1.05E-7	YNL304W	YPT11	hom	Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells
0.090	1.52E-7	YOR055W_d	YOR055W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089	2.19E-7	YKL201C	MNN4	hom	Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.088	3.12E-7	YDR241W_d	BUD26_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.088	3.62E-7	YML069W	POB3	het	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.084	1.19E-6	YDR374C_p	YDR374C_p	hom	Putative protein of unknown function
0.082	1.76E-6	YBR206W_d	YBR206W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3