YJR108W / ABM1

Protein of unknown function, required for normal microtubule organization

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR108W / ABM1

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-3.12|P-value:5.52E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.49|P-value:1.15E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.15|P-value:6.98E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:2.95|P-value:9.23E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.35|P-value:2.05E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.68|P-value:6.01E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:3.00|P-value:7.79E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.71|P-value:4.55E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:3.28|P-value:2.72E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.74|P-value:4.01E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:-5.59|P-value:2.45E-9 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.54|P-value:1.08E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.71|P-value:4.70E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:2.96|P-value:9.02E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.46|P-value:1.32E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.58|P-value:8.35E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.09|P-value:5.55E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-2.97|P-value:9.66E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.14|P-value:4.61E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.06|P-value:7.01E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.23|P-value:3.74E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.96|P-value:1.48E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.02|P-value:7.25E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-2.97|P-value:9.53E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.07|P-value:6.69E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.15|P-value:4.49E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.03|P-value:7.77E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.08|P-value:5.83E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.00|P-value:8.62E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-2.98|P-value:9.14E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.29|P-value:2.62E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.03|P-value:7.88E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.32|P-value:2.64E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-4.22|P-value:5.13E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-3.86|P-value:2.77E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.99|P-value:1.50E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-3.97|P-value:1.62E-5 ID:SGTC_3165|Compound:9101544|FD-Score:2.93|P-value:9.94E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-2.98|P-value:9.40E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.50|P-value:1.25E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.12|P-value:5.52E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.49|P-value:1.15E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.15|P-value:6.98E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:2.95|P-value:9.23E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.35|P-value:2.05E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.68|P-value:6.01E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:3.00|P-value:7.79E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.71|P-value:4.55E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:3.28|P-value:2.72E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.74|P-value:4.01E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:-5.59|P-value:2.45E-9 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.54|P-value:1.08E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.71|P-value:4.70E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:2.96|P-value:9.02E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.46|P-value:1.32E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.58|P-value:8.35E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.09|P-value:5.55E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-2.97|P-value:9.66E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.14|P-value:4.61E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.06|P-value:7.01E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.23|P-value:3.74E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.96|P-value:1.48E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.02|P-value:7.25E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-2.97|P-value:9.53E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.07|P-value:6.69E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.15|P-value:4.49E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.03|P-value:7.77E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.08|P-value:5.83E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.00|P-value:8.62E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-2.98|P-value:9.14E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.29|P-value:2.62E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.03|P-value:7.88E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.32|P-value:2.64E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-4.22|P-value:5.13E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-3.86|P-value:2.77E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.99|P-value:1.50E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-3.97|P-value:1.62E-5 ID:SGTC_3165|Compound:9101544|FD-Score:2.93|P-value:9.94E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-2.98|P-value:9.40E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.50|P-value:1.25E-4

Top fitness defect scores for YJR108W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1783 st039459 3.96 87.5 µM 1.48E-5 Golgi 22 3.69E-5
2 SGTC_736 0958-0254 3.74 92.6 µM 4.01E-5 Golgi 40 9.14E-5
3 SGTC_310 1273-0058 3.71 1.1 µM 4.55E-5 mitochondrial stress 262 1.02E-4
4 SGTC_917 harmaline 3.71 728.1 nM 4.70E-5 ergosterol biosynthesis 34 1.05E-4
5 SGTC_43 0570-0105 3.49 72.5 µM 1.15E-4 ERG2 134 2.38E-4
6 SGTC_1055 3448-0672 3.46 86.0 µM 1.32E-4 51 2.70E-4
7 SGTC_170 4197-0004 3.35 226.0 µM 2.05E-4 33 4.02E-4
8 SGTC_2780 5215298 3.29 71.4 µM 2.62E-4 70 5.03E-4
9 SGTC_532 1548-0774 3.28 215.0 µM 2.72E-4 41 5.21E-4
10 SGTC_1967 st070177 3.15 51.4 µM 4.49E-4 48 8.22E-4
11 SGTC_1378 2093-0007 3.14 380.0 nM 4.61E-4 55 8.41E-4
12 SGTC_1134 3477-0009 3.09 42.5 µM 5.55E-4 87 9.97E-4
13 SGTC_2572 astragaloside iv 3.08 100.0 µM 5.83E-4 70 0.00104
14 SGTC_1842 st055362 3.02 61.2 µM 7.25E-4 52 0.00127
15 SGTC_299 1273-0059 3.00 1.4 µM 7.79E-4 56 0.00136
16 SGTC_996 3970-0799 2.96 1.8 µM 9.02E-4 160 0.00155
17 SGTC_156 3474-0145 2.95 5.6 µM 9.23E-4 endomembrane recycling 102 0.00158
18 SGTC_3165 9101544 2.93 49.5 µM 9.94E-4 43 0.00169
19 SGTC_743 1275-0778 2.92 158.0 µM 0.00103 excess fatty acid 103 0.00174
20 SGTC_2058 5236698 2.92 133.0 µM 0.00103 76 0.00175

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.261 2.59E-53 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.210 1.26E-34 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.199 3.35E-31 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.181 4.20E-26 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.178 2.78E-25 YLR267W_p BOP2_p hom Protein of unknown function
0.169 5.66E-23 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.168 1.31E-22 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.166 3.27E-22 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.164 1.00E-21 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.161 6.17E-21 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.159 1.67E-20 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.158 3.33E-20 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.158 3.44E-20 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.157 5.08E-20 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.157 5.33E-20 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress