YJR115W_p

Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR115W / YJR115W

Click on Significant Values for Screen Details ID:SGTC_132|Compound:0417-1715|FD-Score:3.73|P-value:3.52E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.68|P-value:4.45E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.14|P-value:4.90E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-4.25|P-value:3.90E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:9.80|P-value:1.26E-25 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.37|P-value:2.14E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.51|P-value:1.10E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:10.90|P-value:4.78E-31 ID:SGTC_359|Compound:0081-0058|FD-Score:9.09|P-value:2.52E-22 ID:SGTC_519|Compound:k048-0011|FD-Score:3.09|P-value:4.78E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.09|P-value:5.88E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.08|P-value:6.16E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.15|P-value:3.94E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.29|P-value:2.22E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.79|P-value:2.72E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:5.29|P-value:9.30E-9 ID:SGTC_934|Compound:2950-0684|FD-Score:3.17|P-value:3.61E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.08|P-value:5.06E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.65|P-value:5.06E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.60|P-value:6.25E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.03|P-value:7.35E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.21|P-value:3.68E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.15|P-value:4.59E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-2.99|P-value:8.41E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.26|P-value:2.53E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.14|P-value:4.07E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.08|P-value:6.13E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.10|P-value:5.56E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.95|P-value:8.15E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.37|P-value:2.01E-4 ID:SGTC_2162|Compound:5663267|FD-Score:4.59|P-value:5.20E-7 ID:SGTC_2229|Compound:7354935|FD-Score:3.31|P-value:2.03E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.79|P-value:2.68E-5 ID:SGTC_2281|Compound:7943571|FD-Score:4.60|P-value:4.79E-7 ID:SGTC_2305|Compound:7443522|FD-Score:4.13|P-value:5.54E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.81|P-value:3.06E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-3.19|P-value:3.96E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.01|P-value:7.93E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.44|P-value:3.54E-9 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.08|P-value:6.00E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.98|P-value:1.09E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.49|P-value:1.01E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.98|P-value:7.38E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.04|P-value:7.14E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.44|P-value:1.23E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.33|P-value:2.28E-4 ID:SGTC_2976|Compound:9009005|FD-Score:6.23|P-value:1.80E-11 ID:SGTC_2978|Compound:9011784|FD-Score:4.33|P-value:1.99E-6 ID:SGTC_2984|Compound:9022109|FD-Score:4.15|P-value:4.95E-6 ID:SGTC_3050|Compound:9093513|FD-Score:-3.21|P-value:3.76E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.13|P-value:5.06E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.93|P-value:1.41E-5 ID:SGTC_3109|Compound:9122853|FD-Score:2.90|P-value:9.81E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.26|P-value:3.12E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.73|P-value:3.52E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.68|P-value:4.45E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.14|P-value:4.90E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-4.25|P-value:3.90E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:9.80|P-value:1.26E-25 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.37|P-value:2.14E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.51|P-value:1.10E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:10.90|P-value:4.78E-31 ID:SGTC_359|Compound:0081-0058|FD-Score:9.09|P-value:2.52E-22 ID:SGTC_519|Compound:k048-0011|FD-Score:3.09|P-value:4.78E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.09|P-value:5.88E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.08|P-value:6.16E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.15|P-value:3.94E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.29|P-value:2.22E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.79|P-value:2.72E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:5.29|P-value:9.30E-9 ID:SGTC_934|Compound:2950-0684|FD-Score:3.17|P-value:3.61E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.08|P-value:5.06E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.65|P-value:5.06E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.60|P-value:6.25E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.03|P-value:7.35E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.21|P-value:3.68E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.15|P-value:4.59E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-2.99|P-value:8.41E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.26|P-value:2.53E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.14|P-value:4.07E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.08|P-value:6.13E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.10|P-value:5.56E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.95|P-value:8.15E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.37|P-value:2.01E-4 ID:SGTC_2162|Compound:5663267|FD-Score:4.59|P-value:5.20E-7 ID:SGTC_2229|Compound:7354935|FD-Score:3.31|P-value:2.03E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.79|P-value:2.68E-5 ID:SGTC_2281|Compound:7943571|FD-Score:4.60|P-value:4.79E-7 ID:SGTC_2305|Compound:7443522|FD-Score:4.13|P-value:5.54E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.81|P-value:3.06E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-3.19|P-value:3.96E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.01|P-value:7.93E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.44|P-value:3.54E-9 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.08|P-value:6.00E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.98|P-value:1.09E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.49|P-value:1.01E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.98|P-value:7.38E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.04|P-value:7.14E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.44|P-value:1.23E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.33|P-value:2.28E-4 ID:SGTC_2976|Compound:9009005|FD-Score:6.23|P-value:1.80E-11 ID:SGTC_2978|Compound:9011784|FD-Score:4.33|P-value:1.99E-6 ID:SGTC_2984|Compound:9022109|FD-Score:4.15|P-value:4.95E-6 ID:SGTC_3050|Compound:9093513|FD-Score:-3.21|P-value:3.76E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.13|P-value:5.06E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.93|P-value:1.41E-5 ID:SGTC_3109|Compound:9122853|FD-Score:2.90|P-value:9.81E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.26|P-value:3.12E-4

Top fitness defect scores for YJR115W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_358 0075-0058 10.90 9.4 µM 4.78E-31 2 8.80E-28
2 SGTC_219 mitoxanthrone 9.80 164.4 µM 1.26E-25 DNA intercalators 9 5.91E-23
3 SGTC_359 0081-0058 9.09 15.9 µM 2.52E-22 60S ribosome export 4 5.16E-20
4 SGTC_2976 9009005 6.23 19.5 µM 1.80E-11 10 2.39E-10
5 SGTC_2633 5,7-dihydroxyisoflavone 5.44 100.0 µM 3.54E-9 10 2.63E-8
6 SGTC_827 3253-0474 5.29 693.0 µM 9.30E-9 4 6.23E-8
7 SGTC_2281 7943571 4.60 200.0 µM 4.79E-7 4 2.09E-6
8 SGTC_2162 5663267 4.59 200.0 µM 5.20E-7 7 2.25E-6
9 SGTC_2978 9011784 4.33 43.0 µM 1.99E-6 21 7.41E-6
10 SGTC_2984 9022109 4.15 39.0 µM 4.95E-6 3 1.67E-5
11 SGTC_2305 7443522 4.13 69.2 µM 5.54E-6 10 1.85E-5
12 SGTC_2676 harmalol 3.98 100.0 µM 1.09E-5 mitochondrial processes 9 3.38E-5
13 SGTC_3103 9120822 3.93 49.5 µM 1.41E-5 15 4.26E-5
14 SGTC_2246 7293507 3.79 91.6 µM 2.68E-5 32 7.55E-5
15 SGTC_820 1582-0060 3.79 59.9 µM 2.72E-5 35 7.64E-5
16 SGTC_132 0417-1715 3.73 25.8 µM 3.52E-5 RPP1 & pyrimidine depletion 28 9.61E-5
17 SGTC_172 1112-0046 3.68 2.6 µM 4.45E-5 NEO1 42 1.19E-4
18 SGTC_1251 0490-5699 3.65 265.0 µM 5.06E-5 42 1.33E-4
19 SGTC_1330 1469-0054 3.60 61.8 µM 6.25E-5 iron homeostasis 26 1.61E-4
20 SGTC_2689 tacrolimus 3.49 100.0 µM 1.01E-4 68 2.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 4.68E-22 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.153 5.38E-19 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.150 2.24E-18 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.145 3.92E-17 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.138 1.07E-15 YDR406W PDR15 hom Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.131 2.87E-14 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.128 9.23E-14 YDR405W MRP20 hom Mitochondrial ribosomal protein of the large subunit
0.128 1.15E-13 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.124 4.97E-13 YJR012C_p YJR012C_p het Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
0.123 9.53E-13 YHL007C STE20 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.122 1.13E-12 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.121 2.05E-12 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.120 2.92E-12 YBL019W APN2 hom Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.117 1.30E-11 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.116 1.89E-11 YDR164C SEC1 het Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function