HIPHOP chemogenomics database

YJR116W_p / TDA4

Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele

Zygosity: Homozygous strain

fixedexpanded
Profile for YJR116W / TDA4

Click on Significant Values for Screen Details

Top fitness defect scores for YJR116W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2415	st077333	6.42	57.7 µM	1.65E-15		9	6.81E-11
2	SGTC_996	3970-0799	4.98	1.8 µM	4.59E-10		55	3.12E-7
3	SGTC_219	mitoxanthrone	4.33	164.4 µM	5.10E-8	DNA intercalators	44	7.48E-6
4	SGTC_2724	maprotiline	4.05	69.6 µM	3.21E-7	ERG2	14	2.59E-5
5	SGTC_2419	paclitaxel	4.04	166.5 µM	3.36E-7		35	2.67E-5
6	SGTC_1851	st056236	3.98	18.9 µM	4.88E-7		14	3.44E-5
7	SGTC_1326	1431-2094	3.93	10.8 µM	6.50E-7	tubulin folding & SWR complex	37	4.18E-5
8	SGTC_2444	5485484	3.87	36.4 µM	9.38E-7		39	5.36E-5
9	SGTC_1125	tnp00248	3.51	1.3 µM	7.78E-6		50	2.25E-4
10	SGTC_3313	9133968	3.38	57.0 µM	1.61E-5		14	3.68E-4
11	SGTC_1333	1482-0047	3.33	286.0 µM	2.07E-5		34	4.37E-4
12	SGTC_1520	flindersine	3.08	88.0 µM	7.23E-5		68	0.00102
13	SGTC_428	3448-4153	3.08	16.5 µM	7.29E-5	TSC3-RPN4	76	0.00103
14	SGTC_3266	9136860	3.08	49.5 µM	7.29E-5	cell wall	81	0.00103
15	SGTC_2537	larixol	3.04	68.9 µM	9.01E-5		70	0.00119
16	SGTC_2305	7443522	2.94	69.2 µM	1.44E-4		52	0.00164
17	SGTC_2414	st077232	2.92	92.9 µM	1.57E-4		75	0.00174
18	SGTC_1563	conessine	2.84	56.1 µM	2.33E-4		71	0.00227
19	SGTC_512	prima-1	2.82	270.0 µM	2.48E-4	DNA intercalators	67	0.00237
20	SGTC_953	1188-0045	2.82	9.7 µM	2.51E-4	60S ribosome export	88	0.00239

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.303	4.35E-72	YML118W	NGL3	hom	3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.235	2.86E-43	YGL040C	HEM2	het	Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.216	1.21E-36	YDR505C	PSP1	hom	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.214	4.30E-36	YDL099W	BUG1	hom	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.204	6.18E-33	YOR037W	CYC2	hom	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.193	2.31E-29	YGL205W	POX1	hom	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.188	6.24E-28	YBR207W	FTH1	hom	Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.186	1.51E-27	YGR189C	CRH1	hom	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.184	6.03E-27	YPL262W	FUM1	hom	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.181	3.43E-26	YBR067C	TIP1	hom	Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.175	1.39E-24	YGL083W	SCY1	hom	Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.174	2.49E-24	YGL222C	EDC1	hom	RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.173	7.52E-24	YMR112C	MED11	het	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.169	7.13E-23	YNL273W	TOF1	hom	Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
0.156	1.25E-19	YDL174C	DLD1	hom	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane