YJR117W / STE24

Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR117W / STE24

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:5.68|P-value:4.20E-10 ID:SGTC_32|Compound:0928-0142|FD-Score:2.99|P-value:6.04E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.64|P-value:7.96E-17 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.09|P-value:5.02E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:3.51|P-value:7.55E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.04|P-value:4.97E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.78|P-value:2.19E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.29|P-value:1.77E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:15.70|P-value:3.79E-65 ID:SGTC_568|Compound:1193-0097|FD-Score:4.07|P-value:5.50E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.14|P-value:3.53E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:7.42|P-value:5.73E-16 ID:SGTC_663|Compound:1486-0733|FD-Score:2.98|P-value:6.30E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-2.91|P-value:8.74E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.45|P-value:1.01E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.54|P-value:6.88E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:2.95|P-value:7.01E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-4.52|P-value:5.56E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:2.99|P-value:6.20E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.50|P-value:8.14E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.21|P-value:2.73E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.26|P-value:2.22E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.17|P-value:3.01E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.09|P-value:5.04E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-7.59|P-value:1.36E-16 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.88|P-value:9.57E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-2.90|P-value:9.01E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.05|P-value:1.35E-14 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.74|P-value:2.77E-5 ID:SGTC_1548|Compound:st061468|FD-Score:3.58|P-value:5.53E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.37|P-value:1.36E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.13|P-value:3.75E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.02|P-value:5.42E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-2.95|P-value:7.51E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.04|P-value:5.01E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.12|P-value:3.66E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.48|P-value:6.27E-7 ID:SGTC_2180|Compound:6301957|FD-Score:2.89|P-value:8.91E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.65|P-value:2.56E-7 ID:SGTC_2570|Compound:licareol|FD-Score:-3.76|P-value:2.58E-5 ID:SGTC_2585|Compound:alliin|FD-Score:-3.20|P-value:2.86E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.12|P-value:3.87E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.26|P-value:2.19E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.41|P-value:1.15E-4 ID:SGTC_2734|Compound:clemastine|FD-Score:-2.94|P-value:7.71E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:2.87|P-value:9.55E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-4.59|P-value:3.67E-7 ID:SGTC_2820|Compound:7989630|FD-Score:4.18|P-value:3.16E-6 ID:SGTC_2822|Compound:7994718|FD-Score:-3.11|P-value:3.98E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.28|P-value:2.06E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.12|P-value:3.94E-4 ID:SGTC_3293|Compound:9120939|FD-Score:5.03|P-value:2.67E-8 ID:SGTC_16|Compound:erodoxin|FD-Score:5.68|P-value:4.20E-10 ID:SGTC_32|Compound:0928-0142|FD-Score:2.99|P-value:6.04E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.64|P-value:7.96E-17 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.09|P-value:5.02E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:3.51|P-value:7.55E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.04|P-value:4.97E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.78|P-value:2.19E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.29|P-value:1.77E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:15.70|P-value:3.79E-65 ID:SGTC_568|Compound:1193-0097|FD-Score:4.07|P-value:5.50E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.14|P-value:3.53E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:7.42|P-value:5.73E-16 ID:SGTC_663|Compound:1486-0733|FD-Score:2.98|P-value:6.30E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-2.91|P-value:8.74E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.45|P-value:1.01E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.54|P-value:6.88E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:2.95|P-value:7.01E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-4.52|P-value:5.56E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:2.99|P-value:6.20E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.50|P-value:8.14E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.21|P-value:2.73E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.26|P-value:2.22E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.17|P-value:3.01E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.09|P-value:5.04E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-7.59|P-value:1.36E-16 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.88|P-value:9.57E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-2.90|P-value:9.01E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.05|P-value:1.35E-14 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.74|P-value:2.77E-5 ID:SGTC_1548|Compound:st061468|FD-Score:3.58|P-value:5.53E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.37|P-value:1.36E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.13|P-value:3.75E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.02|P-value:5.42E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-2.95|P-value:7.51E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.04|P-value:5.01E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.12|P-value:3.66E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.48|P-value:6.27E-7 ID:SGTC_2180|Compound:6301957|FD-Score:2.89|P-value:8.91E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.65|P-value:2.56E-7 ID:SGTC_2570|Compound:licareol|FD-Score:-3.76|P-value:2.58E-5 ID:SGTC_2585|Compound:alliin|FD-Score:-3.20|P-value:2.86E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.12|P-value:3.87E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.26|P-value:2.19E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.41|P-value:1.15E-4 ID:SGTC_2734|Compound:clemastine|FD-Score:-2.94|P-value:7.71E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:2.87|P-value:9.55E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-4.59|P-value:3.67E-7 ID:SGTC_2820|Compound:7989630|FD-Score:4.18|P-value:3.16E-6 ID:SGTC_2822|Compound:7994718|FD-Score:-3.11|P-value:3.98E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.28|P-value:2.06E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.12|P-value:3.94E-4 ID:SGTC_3293|Compound:9120939|FD-Score:5.03|P-value:2.67E-8

Top fitness defect scores for YJR117W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_513 4245-1575 15.70 41.7 µM 3.79E-65 unfolded protein response 3 3.47E-56
2 SGTC_103 0844-0104 7.64 51.8 µM 7.96E-17 ERAD & cell cycle 50 1.11E-14
3 SGTC_625 k213-0058 7.42 121.0 µM 5.73E-16 translation 18 6.05E-14
4 SGTC_1161 k007-0610 7.05 110.0 µM 1.35E-14 ERAD & cell cycle 38 9.18E-13
5 SGTC_16 erodoxin 5.68 22.8 µM 4.20E-10 unfolded protein response 29 6.72E-9
6 SGTC_3293 9120939 5.03 62.0 µM 2.67E-8 5 2.40E-7
7 SGTC_2514 salinomycin 4.65 42.7 µM 2.56E-7 26 1.69E-6
8 SGTC_2179 6298986 4.48 200.0 µM 6.27E-7 heme requiring 13 3.65E-6
9 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 4.29 8.0 µM 1.77E-6 20 8.92E-6
10 SGTC_1040 k898-0338 4.21 155.0 µM 2.73E-6 16 1.30E-5
11 SGTC_2820 7989630 4.18 71.4 µM 3.16E-6 ERG2 14 1.47E-5
12 SGTC_219 mitoxanthrone 4.09 164.4 µM 5.02E-6 DNA intercalators 49 2.19E-5
13 SGTC_1083 didemethylchlorpromazine sulfoxide 4.09 707.4 nM 5.04E-6 redox potentiating 74 2.20E-5
14 SGTC_568 1193-0097 4.07 7.5 µM 5.50E-6 ERAD & cell cycle 140 2.38E-5
15 SGTC_384 k007-0144 3.78 5.2 µM 2.19E-5 ERAD & cell cycle 64 7.82E-5
16 SGTC_1548 st061468 3.58 90.8 µM 5.53E-5 15 1.74E-4
17 SGTC_352 k048-0007 3.51 5.1 µM 7.55E-5 ERAD & cell cycle 95 2.28E-4
18 SGTC_2724 maprotiline 3.41 69.6 µM 1.15E-4 ERG2 29 3.29E-4
19 SGTC_1587 estradiol valerate 3.37 56.1 µM 1.36E-4 27 3.78E-4
20 SGTC_1043 0916-0009 3.17 19.3 µM 3.01E-4 55 7.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.318 1.21E-79 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.261 3.63E-53 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.250 4.14E-49 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.248 3.21E-48 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.237 5.71E-44 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.236 8.05E-44 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.229 3.57E-41 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.225 7.24E-40 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.225 1.23E-39 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.224 1.46E-39 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.219 9.40E-38 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.213 9.19E-36 YMR161W HLJ1 hom Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ
0.210 8.43E-35 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress
0.209 1.72E-34 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.208 4.55E-34 YML105C SEC65 het Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19