YJR119C / JHD2

JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR119C / JHD2

Click on Significant Values for Screen Details ID:SGTC_264|Compound:promethazine|FD-Score:-4.91|P-value:1.69E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.15|P-value:5.83E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.09|P-value:4.55E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.76|P-value:2.84E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:5.86|P-value:2.27E-10 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.19|P-value:5.10E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:-3.45|P-value:1.87E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:2.95|P-value:7.50E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.18|P-value:5.33E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.59|P-value:1.04E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.86|P-value:1.87E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:3.97|P-value:1.10E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:2.88|P-value:9.75E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.05|P-value:5.24E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.03|P-value:5.66E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.08|P-value:6.41E-6 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.22|P-value:3.34E-6 ID:SGTC_1656|Compound:st012921|FD-Score:3.21|P-value:2.91E-4 ID:SGTC_1662|Compound:st014054|FD-Score:3.72|P-value:3.46E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.88|P-value:2.95E-5 ID:SGTC_1937|Compound:st074714|FD-Score:2.89|P-value:9.52E-4 ID:SGTC_1942|Compound:st076330|FD-Score:2.99|P-value:6.63E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-4.06|P-value:1.31E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.87|P-value:1.70E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-3.12|P-value:6.58E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.43|P-value:1.10E-6 ID:SGTC_2117|Compound:5521686|FD-Score:3.09|P-value:4.60E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.12|P-value:6.55E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.11|P-value:6.77E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.01|P-value:1.66E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.42|P-value:1.24E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.25|P-value:4.09E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.31|P-value:3.19E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.53|P-value:1.35E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.91|P-value:1.44E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.77|P-value:2.78E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.41|P-value:1.31E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.34|P-value:2.81E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.24|P-value:2.51E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-4.91|P-value:1.69E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.15|P-value:5.83E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.09|P-value:4.55E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.76|P-value:2.84E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:5.86|P-value:2.27E-10 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.19|P-value:5.10E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:-3.45|P-value:1.87E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:2.95|P-value:7.50E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.18|P-value:5.33E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.59|P-value:1.04E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.86|P-value:1.87E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:3.97|P-value:1.10E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:2.88|P-value:9.75E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.05|P-value:5.24E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.03|P-value:5.66E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.08|P-value:6.41E-6 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.22|P-value:3.34E-6 ID:SGTC_1656|Compound:st012921|FD-Score:3.21|P-value:2.91E-4 ID:SGTC_1662|Compound:st014054|FD-Score:3.72|P-value:3.46E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.88|P-value:2.95E-5 ID:SGTC_1937|Compound:st074714|FD-Score:2.89|P-value:9.52E-4 ID:SGTC_1942|Compound:st076330|FD-Score:2.99|P-value:6.63E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-4.06|P-value:1.31E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.87|P-value:1.70E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-3.12|P-value:6.58E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.43|P-value:1.10E-6 ID:SGTC_2117|Compound:5521686|FD-Score:3.09|P-value:4.60E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.12|P-value:6.55E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.11|P-value:6.77E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.01|P-value:1.66E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.42|P-value:1.24E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.25|P-value:4.09E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.31|P-value:3.19E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.53|P-value:1.35E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.91|P-value:1.44E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.77|P-value:2.78E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.41|P-value:1.31E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.34|P-value:2.81E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.24|P-value:2.51E-4

Top fitness defect scores for YJR119C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_355 1311-2252 5.86 105.0 µM 2.27E-10 3 2.29E-9
2 SGTC_2112 5488546 4.43 200.0 µM 1.10E-6 TSC3-RPN4 14 4.61E-6
3 SGTC_1487 3970-0795 4.22 2.8 µM 3.34E-6 DNA intercalators 4 1.24E-5
4 SGTC_1430 4049-0248 4.08 69.1 µM 6.41E-6 16 2.22E-5
5 SGTC_1081 sertraline 3.97 6.0 µM 1.10E-5 60S ribosome export 35 3.59E-5
6 SGTC_2671 danthron 3.91 100.0 µM 1.44E-5 DNA damage response 44 4.58E-5
7 SGTC_2058 5236698 3.87 133.0 µM 1.70E-5 29 5.33E-5
8 SGTC_988 1497-1057 3.86 103.0 µM 1.87E-5 11 5.79E-5
9 SGTC_2806 7952793 3.77 58.4 µM 2.78E-5 29 8.28E-5
10 SGTC_344 k064-0035 3.76 6.4 µM 2.84E-5 60S ribosome export 24 8.42E-5
11 SGTC_1662 st014054 3.72 52.0 µM 3.46E-5 TSC3-RPN4 4 1.00E-4
12 SGTC_2444 5485484 3.42 36.4 µM 1.24E-4 53 3.15E-4
13 SGTC_2935 9038016 3.41 30.0 µM 1.31E-4 32 3.31E-4
14 SGTC_3004 9076122 3.24 71.4 µM 2.51E-4 37 5.91E-4
15 SGTC_1656 st012921 3.21 11.0 µM 2.91E-4 53 6.74E-4
16 SGTC_343 4130-2827 3.09 29.8 µM 4.55E-4 73 0.00101
17 SGTC_2117 5521686 3.09 200.0 µM 4.60E-4 51 0.00102
18 SGTC_1292 0kpi-0043 3.05 232.0 µM 5.24E-4 50 0.00114
19 SGTC_1312 1218-2183 3.03 165.0 µM 5.66E-4 31 0.00122
20 SGTC_1942 st076330 2.99 65.2 µM 6.63E-4 74 0.00141

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.99E-12 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.118 8.65E-12 YGL085W_p LCL3_p hom Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS
0.105 1.24E-9 YLR394W CST9 hom SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
0.102 3.16E-9 YOR328W PDR10 hom ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
0.102 3.40E-9 YOL073C YOL073C hom Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2
0.100 6.30E-9 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.099 1.05E-8 YJL035C TAD2 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
0.097 1.80E-8 YPR111W DBF20 hom Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs
0.095 3.61E-8 YGR123C PPT1 hom Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth
0.094 5.68E-8 YLR246W ERF2 hom Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole
0.094 5.54E-8 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.086 5.56E-7 YNL031C HHT2 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation
0.086 6.10E-7 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.086 6.84E-7 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.085 7.90E-7 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function