YJR120W

Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR120W / YJR120W

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:4.29|P-value:7.36E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:3.69|P-value:9.63E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:25.00|P-value:3.46E-141 ID:SGTC_310|Compound:1273-0058|FD-Score:4.23|P-value:9.79E-6 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.07|P-value:9.54E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.22|P-value:5.76E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:-3.46|P-value:2.41E-4 ID:SGTC_1635|Compound:st007035|FD-Score:14.20|P-value:8.40E-47 ID:SGTC_1678|Compound:st019265|FD-Score:3.70|P-value:9.22E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.80|P-value:6.14E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.63|P-value:1.22E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.60|P-value:1.40E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.24|P-value:5.42E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.34|P-value:3.71E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.36|P-value:3.41E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.15|P-value:7.29E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.60|P-value:1.37E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.30|P-value:4.38E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.96|P-value:3.16E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.60|P-value:1.42E-4 ID:SGTC_2956|Compound:9076196|FD-Score:8.72|P-value:6.94E-19 ID:SGTC_2961|Compound:9083290|FD-Score:5.01|P-value:2.08E-7 ID:SGTC_2990|Compound:9074105|FD-Score:3.59|P-value:1.44E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.29|P-value:7.36E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:3.69|P-value:9.63E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:25.00|P-value:3.46E-141 ID:SGTC_310|Compound:1273-0058|FD-Score:4.23|P-value:9.79E-6 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.07|P-value:9.54E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.22|P-value:5.76E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:-3.46|P-value:2.41E-4 ID:SGTC_1635|Compound:st007035|FD-Score:14.20|P-value:8.40E-47 ID:SGTC_1678|Compound:st019265|FD-Score:3.70|P-value:9.22E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.80|P-value:6.14E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.63|P-value:1.22E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.60|P-value:1.40E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.24|P-value:5.42E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.34|P-value:3.71E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.36|P-value:3.41E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.15|P-value:7.29E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.60|P-value:1.37E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.30|P-value:4.38E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.96|P-value:3.16E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.60|P-value:1.42E-4 ID:SGTC_2956|Compound:9076196|FD-Score:8.72|P-value:6.94E-19 ID:SGTC_2961|Compound:9083290|FD-Score:5.01|P-value:2.08E-7 ID:SGTC_2990|Compound:9074105|FD-Score:3.59|P-value:1.44E-4

Top fitness defect scores for YJR120W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 25.00 5.3 µM 3.46E-141 31 1.30E-138
2 SGTC_1635 st007035 14.20 42.4 µM 8.40E-47 46 5.69E-46
3 SGTC_2956 9076196 8.72 2.5 µM 6.94E-19 1 1.44E-18
4 SGTC_2961 9083290 5.01 32.5 µM 2.08E-7 7 2.67E-7
5 SGTC_59 0330-0160 4.29 1.3 µM 7.36E-6 95 8.84E-6
6 SGTC_310 1273-0058 4.23 1.1 µM 9.79E-6 mitochondrial stress 227 1.17E-5
7 SGTC_2784 7567673 3.96 72.7 µM 3.16E-5 iron homeostasis 30 3.70E-5
8 SGTC_1853 st056710 3.80 91.2 µM 6.14E-5 amide catabolism 30 7.11E-5
9 SGTC_1678 st019265 3.70 80.2 µM 9.22E-5 60S ribosome export 27 1.06E-4
10 SGTC_67 0335-0847 3.69 266.0 µM 9.63E-5 ubiquinone biosynthesis & proteasome 134 1.11E-4
11 SGTC_2100 5377183 3.63 190.0 µM 1.22E-4 60S ribosome export 16 1.40E-4
12 SGTC_2568 diosmetin 3.60 100.0 µM 1.37E-4 33 1.56E-4
13 SGTC_2299 7976368 3.60 114.9 µM 1.40E-4 41 1.59E-4
14 SGTC_2930 9013230 3.60 14.9 µM 1.42E-4 heme biosynthesis & mitochondrial translocase 53 1.62E-4
15 SGTC_2990 9074105 3.59 71.4 µM 1.44E-4 7 1.64E-4
16 SGTC_2493 resveratrol 3.36 26.1 µM 3.41E-4 17 3.83E-4
17 SGTC_2453 5731132 3.34 22.2 µM 3.71E-4 42 4.17E-4
18 SGTC_2303 7774051 3.24 200.0 µM 5.42E-4 45 6.04E-4
19 SGTC_1371 2421-0008 3.22 32.7 µM 5.76E-4 mitochondrial processes 78 6.41E-4
20 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.15 3.7 µM 7.29E-4 175 8.08E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.741 0 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.710 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.685 0 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.672 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.655 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.640 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.633 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.627 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.612 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.608 0 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.606 0 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.604 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.599 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.596 1.22E-321 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.595 6.72E-320 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding