YJR123W / RPS5

Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR123W / RPS5

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.12|P-value:7.58E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.40|P-value:2.92E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.40|P-value:2.88E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:4.01|P-value:2.81E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.43|P-value:7.19E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.07|P-value:9.13E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.72|P-value:1.01E-13 ID:SGTC_378|Compound:3970-0959|FD-Score:3.86|P-value:5.02E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:-4.55|P-value:9.81E-6 ID:SGTC_490|Compound:phenamil|FD-Score:-4.18|P-value:4.60E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.37|P-value:3.22E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.41|P-value:2.84E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.70|P-value:4.92E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:3.85|P-value:5.31E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.49|P-value:2.13E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.58|P-value:2.24E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:6.83|P-value:6.76E-12 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.27|P-value:4.66E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.44|P-value:1.53E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:3.94|P-value:3.75E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.51|P-value:1.98E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:6.78|P-value:9.14E-12 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.49|P-value:2.08E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.45|P-value:2.41E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.61|P-value:1.99E-6 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.46|P-value:6.50E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.63|P-value:1.26E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.41|P-value:2.76E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.48|P-value:3.56E-6 ID:SGTC_1520|Compound:flindersine|FD-Score:3.38|P-value:3.14E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:5.34|P-value:5.29E-8 ID:SGTC_1650|Compound:st011916|FD-Score:-3.70|P-value:2.79E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.38|P-value:8.51E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.96|P-value:3.47E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.47|P-value:2.22E-4 ID:SGTC_1860|Compound:st056228|FD-Score:7.67|P-value:1.68E-14 ID:SGTC_1900|Compound:st060200|FD-Score:3.49|P-value:2.11E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.77|P-value:7.29E-5 ID:SGTC_1902|Compound:st060212|FD-Score:4.15|P-value:1.53E-5 ID:SGTC_1904|Compound:st060225|FD-Score:3.57|P-value:1.59E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.39|P-value:8.19E-4 ID:SGTC_2072|Compound:5231554|FD-Score:3.24|P-value:5.19E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.38|P-value:8.57E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.37|P-value:3.25E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.11|P-value:7.94E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.43|P-value:2.64E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:-3.79|P-value:2.02E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-5.58|P-value:6.66E-8 ID:SGTC_2264|Compound:7948757|FD-Score:4.47|P-value:3.81E-6 ID:SGTC_2273|Compound:7815444|FD-Score:-4.09|P-value:6.62E-5 ID:SGTC_2290|Compound:7904846|FD-Score:6.66|P-value:2.04E-11 ID:SGTC_2331|Compound:7980721|FD-Score:5.00|P-value:3.00E-7 ID:SGTC_2446|Compound:5162541|FD-Score:3.40|P-value:2.90E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.66|P-value:1.10E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:5.48|P-value:2.40E-8 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.87|P-value:4.86E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.62|P-value:1.31E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.03|P-value:8.22E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.74|P-value:2.47E-4 ID:SGTC_2804|Compound:7954240|FD-Score:6.74|P-value:1.18E-11 ID:SGTC_2805|Compound:7950783|FD-Score:-6.48|P-value:3.93E-10 ID:SGTC_2810|Compound:7959871|FD-Score:-7.39|P-value:1.04E-12 ID:SGTC_2812|Compound:7970281|FD-Score:4.25|P-value:1.01E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.48|P-value:3.56E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.58|P-value:1.51E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.53|P-value:5.17E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.13|P-value:7.31E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.12|P-value:7.58E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.40|P-value:2.92E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.40|P-value:2.88E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:4.01|P-value:2.81E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.43|P-value:7.19E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.07|P-value:9.13E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.72|P-value:1.01E-13 ID:SGTC_378|Compound:3970-0959|FD-Score:3.86|P-value:5.02E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:-4.55|P-value:9.81E-6 ID:SGTC_490|Compound:phenamil|FD-Score:-4.18|P-value:4.60E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.37|P-value:3.22E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.41|P-value:2.84E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.70|P-value:4.92E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:3.85|P-value:5.31E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.49|P-value:2.13E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.58|P-value:2.24E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:6.83|P-value:6.76E-12 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.27|P-value:4.66E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.44|P-value:1.53E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:3.94|P-value:3.75E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.51|P-value:1.98E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:6.78|P-value:9.14E-12 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.49|P-value:2.08E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.45|P-value:2.41E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.61|P-value:1.99E-6 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.46|P-value:6.50E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.63|P-value:1.26E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.41|P-value:2.76E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.48|P-value:3.56E-6 ID:SGTC_1520|Compound:flindersine|FD-Score:3.38|P-value:3.14E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:5.34|P-value:5.29E-8 ID:SGTC_1650|Compound:st011916|FD-Score:-3.70|P-value:2.79E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.38|P-value:8.51E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.96|P-value:3.47E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.47|P-value:2.22E-4 ID:SGTC_1860|Compound:st056228|FD-Score:7.67|P-value:1.68E-14 ID:SGTC_1900|Compound:st060200|FD-Score:3.49|P-value:2.11E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.77|P-value:7.29E-5 ID:SGTC_1902|Compound:st060212|FD-Score:4.15|P-value:1.53E-5 ID:SGTC_1904|Compound:st060225|FD-Score:3.57|P-value:1.59E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.39|P-value:8.19E-4 ID:SGTC_2072|Compound:5231554|FD-Score:3.24|P-value:5.19E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.38|P-value:8.57E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.37|P-value:3.25E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.11|P-value:7.94E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.43|P-value:2.64E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:-3.79|P-value:2.02E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-5.58|P-value:6.66E-8 ID:SGTC_2264|Compound:7948757|FD-Score:4.47|P-value:3.81E-6 ID:SGTC_2273|Compound:7815444|FD-Score:-4.09|P-value:6.62E-5 ID:SGTC_2290|Compound:7904846|FD-Score:6.66|P-value:2.04E-11 ID:SGTC_2331|Compound:7980721|FD-Score:5.00|P-value:3.00E-7 ID:SGTC_2446|Compound:5162541|FD-Score:3.40|P-value:2.90E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.66|P-value:1.10E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:5.48|P-value:2.40E-8 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.87|P-value:4.86E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.62|P-value:1.31E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.03|P-value:8.22E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.74|P-value:2.47E-4 ID:SGTC_2804|Compound:7954240|FD-Score:6.74|P-value:1.18E-11 ID:SGTC_2805|Compound:7950783|FD-Score:-6.48|P-value:3.93E-10 ID:SGTC_2810|Compound:7959871|FD-Score:-7.39|P-value:1.04E-12 ID:SGTC_2812|Compound:7970281|FD-Score:4.25|P-value:1.01E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.48|P-value:3.56E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.58|P-value:1.51E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.53|P-value:5.17E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.13|P-value:7.31E-4

Top fitness defect scores for YJR123W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1860 st056228 7.67 74.6 µM 1.68E-14 1 8.44E-15 2.81
2 SGTC_913 3487-1245 6.83 167.0 µM 6.76E-12 2 4.37E-12 0.40
3 SGTC_1014 4130-3005 6.78 69.3 µM 9.14E-12 1 5.98E-12 1.65
4 SGTC_2804 7954240 6.74 19.5 µM 1.18E-11 2 7.77E-12 0.37
5 SGTC_2290 7904846 6.66 200.0 µM 2.04E-11 4 1.38E-11 0.33
6 SGTC_2546 rhodinyl acetate 5.48 100.0 µM 2.40E-8 3 2.11E-8 0.51
7 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 5.34 67.5 µM 5.29E-8 5 4.78E-8 1.08
8 SGTC_2331 7980721 5.00 200.0 µM 3.00E-7 7 2.88E-7 0.08
9 SGTC_1252 0493-0875 4.61 34.8 µM 1.99E-6 4 2.02E-6 0.31
10 SGTC_832 4083-0019 4.58 164.0 µM 2.24E-6 translation 18 2.29E-6 0.05
11 SGTC_1455 4262-0120 4.48 131.0 µM 3.56E-6 plasma membrane duress 3 3.68E-6 0.62
12 SGTC_2887 9044784 4.48 58.4 µM 3.56E-6 fatty acid desaturase (OLE1) 14 3.68E-6 0.10
13 SGTC_2264 7948757 4.47 110.8 µM 3.81E-6 3 3.94E-6 0.69
14 SGTC_2812 7970281 4.25 58.4 µM 1.01E-5 6 1.07E-5 0.15
15 SGTC_1902 st060212 4.15 70.5 µM 1.53E-5 5 1.65E-5 0.60
16 SGTC_224 benfluorex 4.01 43.9 µM 2.81E-5 4 3.08E-5 0.11
17 SGTC_1856 st057054 3.96 55.7 µM 3.47E-5 2 3.83E-5 0.16
18 SGTC_945 3381-0768 3.94 11.3 µM 3.75E-5 endomembrane recycling 9 4.14E-5 0.07
19 SGTC_2553 4-methylesculetin 3.87 85.1 µM 4.86E-5 4 5.40E-5 0.20
20 SGTC_378 3970-0959 3.86 8.3 µM 5.02E-5 3 5.58E-5 0.39

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 1.58E-31 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.165 7.32E-22 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.158 3.59E-20 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.151 1.86E-18 YMR309C NIP1 het eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
0.118 7.58E-12 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.117 1.23E-11 YPL142C_d YPL142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
0.114 3.91E-11 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.111 1.35E-10 YBR029C CDS1 het Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
0.100 6.87E-9 YLR251W SYM1 hom Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
0.099 8.35E-9 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.096 2.24E-8 YJL199C_d MBB1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
0.095 3.63E-8 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.095 4.27E-8 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.091 1.43E-7 YLR167W RPS31 het Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog
0.090 1.76E-7 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication