YJR133W / XPT1

Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR133W / XPT1

Click on Significant Values for Screen Details ID:SGTC_296|Compound:1222-0039|FD-Score:3.51|P-value:1.39E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.17|P-value:5.21E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.21|P-value:4.40E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.44|P-value:1.86E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.71|P-value:4.38E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.21|P-value:4.43E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.38|P-value:2.77E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.08|P-value:5.59E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.29|P-value:3.23E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.11|P-value:6.46E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.71|P-value:4.34E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.62|P-value:7.76E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.07|P-value:5.68E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.03|P-value:8.53E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.33|P-value:2.15E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-4.04|P-value:9.93E-6 ID:SGTC_2957|Compound:9076800|FD-Score:4.02|P-value:1.49E-5 ID:SGTC_3002|Compound:9075603|FD-Score:-3.37|P-value:1.83E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-4.32|P-value:2.55E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.17|P-value:5.10E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.51|P-value:1.39E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.17|P-value:5.21E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.21|P-value:4.40E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.44|P-value:1.86E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.71|P-value:4.38E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.21|P-value:4.43E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.38|P-value:2.77E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.08|P-value:5.59E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.29|P-value:3.23E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.11|P-value:6.46E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.71|P-value:4.34E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.62|P-value:7.76E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.07|P-value:5.68E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.03|P-value:8.53E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.33|P-value:2.15E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-4.04|P-value:9.93E-6 ID:SGTC_2957|Compound:9076800|FD-Score:4.02|P-value:1.49E-5 ID:SGTC_3002|Compound:9075603|FD-Score:-3.37|P-value:1.83E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-4.32|P-value:2.55E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.17|P-value:5.10E-4

Top fitness defect scores for YJR133W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2568 diosmetin 4.62 100.0 µM 7.76E-7 15 1.88E-6
2 SGTC_1233 0325-0408 4.38 14.2 µM 2.77E-6 14 6.05E-6
3 SGTC_2957 9076800 4.02 11.5 µM 1.49E-5 21 2.86E-5
4 SGTC_296 1222-0039 3.51 74.9 µM 1.39E-4 20 2.25E-4
5 SGTC_1124 fisetin 3.44 1.2 µM 1.86E-4 54 2.95E-4
6 SGTC_2058 5236698 3.29 133.0 µM 3.23E-4 49 4.92E-4
7 SGTC_597 k018-0003 3.21 82.8 µM 4.40E-4 RNA pol III & RNase P/MRP 30 6.56E-4
8 SGTC_1229 0139-0193 3.21 12.2 µM 4.43E-4 RSC complex & mRNA processing 36 6.61E-4
9 SGTC_3197 9113331 3.17 49.5 µM 5.10E-4 73 7.53E-4
10 SGTC_534 k292-0788 3.17 63.4 µM 5.21E-4 mitochondrial processes 56 7.68E-4
11 SGTC_2344 7990960 3.11 77.0 µM 6.46E-4 58 9.37E-4
12 SGTC_2857 9024691 3.03 58.4 µM 8.53E-4 72 0.00121
13 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 2.91 70.1 µM 0.00132 97 0.00182
14 SGTC_1905 st060207 2.89 84.5 µM 0.00139 44 0.00191
15 SGTC_3293 9120939 2.87 62.0 µM 0.00150 63 0.00205
16 SGTC_1520 flindersine 2.86 88.0 µM 0.00157 93 0.00214
17 SGTC_1287 0971-0001 2.86 34.6 µM 0.00158 sphingolipid biosynthesis & PDR1 107 0.00215
18 SGTC_1503 4585-0012 2.82 61.3 µM 0.00178 71 0.00240
19 SGTC_1312 1218-2183 2.76 165.0 µM 0.00220 49 0.00293
20 SGTC_538 2922-0838 2.74 53.3 µM 0.00232 Golgi 109 0.00307

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 3.50E-18 YKL018C-A_p YKL018C-A_p hom Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.142 1.14E-16 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.141 2.06E-16 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.125 3.80E-13 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.124 5.05E-13 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.122 1.21E-12 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.110 1.93E-10 YOL125W TRM13 hom 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
0.109 2.15E-10 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.108 4.39E-10 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.107 6.01E-10 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.105 9.85E-10 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.103 2.24E-9 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.103 2.47E-9 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.102 3.09E-9 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.102 3.20E-9 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio