YJR137C / MET5

Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR137C / MET5

Click on Significant Values for Screen Details ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.74|P-value:5.67E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.09|P-value:9.03E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-5.60|P-value:1.17E-11 ID:SGTC_277|Compound:nystatin|FD-Score:-2.78|P-value:4.75E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:2.71|P-value:5.08E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.35|P-value:1.11E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.19|P-value:3.01E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.12|P-value:3.14E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.79|P-value:3.47E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-2.88|P-value:3.15E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.94|P-value:2.43E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.17|P-value:8.27E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.94|P-value:2.40E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.06|P-value:1.36E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.13|P-value:9.97E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.62|P-value:9.55E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.31|P-value:1.18E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.82|P-value:1.83E-12 ID:SGTC_1524|Compound:corynanthine|FD-Score:2.77|P-value:3.81E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.64|P-value:5.15E-6 ID:SGTC_2016|Compound:5121758|FD-Score:-3.02|P-value:1.65E-4 ID:SGTC_2246|Compound:7293507|FD-Score:4.57|P-value:1.59E-8 ID:SGTC_2415|Compound:st077333|FD-Score:2.77|P-value:3.83E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.55|P-value:9.75E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.20|P-value:7.13E-5 ID:SGTC_2625|Compound:euphol|FD-Score:2.95|P-value:1.74E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.69|P-value:5.38E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-2.76|P-value:5.23E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-5.01|P-value:1.10E-9 ID:SGTC_2991|Compound:9074669|FD-Score:4.82|P-value:2.90E-9 ID:SGTC_3200|Compound:9114385|FD-Score:-2.70|P-value:6.81E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-2.78|P-value:4.79E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-3.11|P-value:1.11E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.74|P-value:5.67E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.09|P-value:9.03E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-5.60|P-value:1.17E-11 ID:SGTC_277|Compound:nystatin|FD-Score:-2.78|P-value:4.75E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:2.71|P-value:5.08E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.35|P-value:1.11E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.19|P-value:3.01E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.12|P-value:3.14E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.79|P-value:3.47E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-2.88|P-value:3.15E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.94|P-value:2.43E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.17|P-value:8.27E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.94|P-value:2.40E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.06|P-value:1.36E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.13|P-value:9.97E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.62|P-value:9.55E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.31|P-value:1.18E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.82|P-value:1.83E-12 ID:SGTC_1524|Compound:corynanthine|FD-Score:2.77|P-value:3.81E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.64|P-value:5.15E-6 ID:SGTC_2016|Compound:5121758|FD-Score:-3.02|P-value:1.65E-4 ID:SGTC_2246|Compound:7293507|FD-Score:4.57|P-value:1.59E-8 ID:SGTC_2415|Compound:st077333|FD-Score:2.77|P-value:3.83E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.55|P-value:9.75E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.20|P-value:7.13E-5 ID:SGTC_2625|Compound:euphol|FD-Score:2.95|P-value:1.74E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.69|P-value:5.38E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-2.76|P-value:5.23E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-5.01|P-value:1.10E-9 ID:SGTC_2991|Compound:9074669|FD-Score:4.82|P-value:2.90E-9 ID:SGTC_3200|Compound:9114385|FD-Score:-2.70|P-value:6.81E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-2.78|P-value:4.79E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-3.11|P-value:1.11E-4

Top fitness defect scores for YJR137C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2991 9074669 4.82 71.4 µM 2.90E-9 azole & statin 37 7.27E-7
2 SGTC_2246 7293507 4.57 91.6 µM 1.59E-8 21 2.38E-6
3 SGTC_453 enantio-paf c16 4.12 10.0 µM 3.14E-7 130 1.91E-5
4 SGTC_2002 4023503 3.64 131.0 µM 5.15E-6 mitochondrial processes 44 1.35E-4
5 SGTC_261 5-fluorouridine 3.09 15.4 µM 9.03E-5 exosome 50 0.00101
6 SGTC_2625 euphol 2.95 100.0 µM 1.74E-4 87 0.00160
7 SGTC_457 grayanotoxin iii 2.79 135.0 µM 3.47E-4 163 0.00261
8 SGTC_1524 corynanthine 2.77 62.1 µM 3.81E-4 86 0.00279
9 SGTC_2415 st077333 2.77 57.7 µM 3.83E-4 138 0.00280
10 SGTC_358 0075-0058 2.71 9.4 µM 5.08E-4 169 0.00341
11 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 2.69 100.0 µM 5.38E-4 108 0.00356
12 SGTC_2568 diosmetin 2.55 100.0 µM 9.75E-4 119 0.00541
13 SGTC_1997 st073024 2.51 93.8 µM 0.00116 70 0.00611
14 SGTC_3219 9131112 2.46 49.5 µM 0.00139 Golgi 124 0.00697
15 SGTC_3139 9095020 2.46 49.5 µM 0.00141 58 0.00704
16 SGTC_3293 9120939 2.44 62.0 µM 0.00149 116 0.00731
17 SGTC_1282 0886-0010 2.39 32.4 µM 0.00181 endomembrane recycling 154 0.00839
18 SGTC_912 3474-0017 2.38 2.2 µM 0.00186 126 0.00855
19 SGTC_2564 betulinic acid 2.34 100.0 µM 0.00217 178 0.00953
20 SGTC_2679 rapamycin 2.34 1.0 nM 0.00219 311 0.00961

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.344 1.72E-93 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.342 2.12E-92 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.338 3.07E-90 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.328 9.15E-85 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.324 8.32E-83 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.314 1.01E-77 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.311 8.82E-76 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.311 7.76E-76 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.306 1.33E-73 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.303 1.33E-71 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.300 1.02E-70 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.297 3.36E-69 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.283 9.98E-63 YCR021C HSP30 hom Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
0.279 5.39E-61 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.278 2.38E-60 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p