YJR139C / HOM6

Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR139C / HOM6

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:8.96|P-value:1.61E-16 ID:SGTC_18|Compound:0111-0177|FD-Score:4.13|P-value:8.39E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:4.05|P-value:1.12E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:8.76|P-value:7.17E-16 ID:SGTC_46|Compound:0329-0187a|FD-Score:8.67|P-value:1.31E-15 ID:SGTC_59|Compound:0330-0160|FD-Score:9.15|P-value:3.64E-17 ID:SGTC_73|Compound:0327-0325|FD-Score:8.01|P-value:1.39E-13 ID:SGTC_81|Compound:0411-0046|FD-Score:7.52|P-value:3.48E-12 ID:SGTC_84|Compound:0443-0269|FD-Score:4.18|P-value:6.91E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:8.50|P-value:4.74E-15 ID:SGTC_90|Compound:0870-0863|FD-Score:10.60|P-value:1.68E-22 ID:SGTC_96|Compound:0929-0093|FD-Score:5.40|P-value:4.28E-7 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:12.20|P-value:4.88E-29 ID:SGTC_127|Compound:0180-0333|FD-Score:4.39|P-value:3.16E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.82|P-value:2.48E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.77|P-value:2.92E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:7.35|P-value:1.01E-11 ID:SGTC_150|Compound:3970-0969|FD-Score:6.40|P-value:2.67E-9 ID:SGTC_159|Compound:3970-0959|FD-Score:9.50|P-value:2.30E-18 ID:SGTC_163|Compound:1327-0036|FD-Score:18.80|P-value:3.92E-66 ID:SGTC_168|Compound:3970-0862|FD-Score:10.10|P-value:1.19E-20 ID:SGTC_177|Compound:1327-0068|FD-Score:6.94|P-value:1.25E-10 ID:SGTC_181|Compound:1447-1644|FD-Score:3.87|P-value:2.13E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:18.20|P-value:2.25E-62 ID:SGTC_210|Compound:3551-0445|FD-Score:3.84|P-value:2.28E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:12.60|P-value:1.00E-30 ID:SGTC_235|Compound:0330-0087|FD-Score:4.09|P-value:9.78E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:8.60|P-value:2.33E-15 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.87|P-value:2.10E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:9.68|P-value:5.68E-19 ID:SGTC_260|Compound:nsc-65238|FD-Score:8.17|P-value:4.60E-14 ID:SGTC_274|Compound:sirtinol|FD-Score:3.92|P-value:1.74E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.52|P-value:6.71E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.66|P-value:4.19E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.88|P-value:2.01E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.75|P-value:3.20E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.69|P-value:3.86E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:24.10|P-value:2.47E-107 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.96|P-value:1.52E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:10.40|P-value:1.37E-21 ID:SGTC_386|Compound:1509-0011|FD-Score:7.95|P-value:2.17E-13 ID:SGTC_428|Compound:3448-4153|FD-Score:3.43|P-value:8.72E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.56|P-value:1.58E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-4.69|P-value:9.75E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:7.03|P-value:7.16E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.35|P-value:5.30E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.59|P-value:2.30E-12 ID:SGTC_492|Compound:tmb-8|FD-Score:17.90|P-value:5.68E-60 ID:SGTC_513|Compound:4245-1575|FD-Score:13.30|P-value:5.62E-34 ID:SGTC_564|Compound:3555-0129|FD-Score:3.67|P-value:4.12E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.42|P-value:2.75E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.53|P-value:6.41E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.93|P-value:3.44E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:12.60|P-value:5.11E-31 ID:SGTC_718|Compound:1130-0073|FD-Score:4.24|P-value:5.47E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:4.77|P-value:6.83E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:3.50|P-value:7.19E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.01|P-value:2.51E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.42|P-value:9.18E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.67|P-value:1.01E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.79|P-value:2.78E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:14.50|P-value:2.78E-40 ID:SGTC_975|Compound:1335-0046|FD-Score:3.94|P-value:1.66E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.44|P-value:8.67E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:4.92|P-value:3.66E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:6.15|P-value:1.01E-8 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.52|P-value:6.73E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.85|P-value:2.22E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:8.45|P-value:6.56E-15 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.83|P-value:2.40E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.03|P-value:1.18E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.58|P-value:5.54E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.99|P-value:1.37E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:18.70|P-value:1.83E-65 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.40|P-value:3.04E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.67|P-value:4.19E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.13|P-value:8.36E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.77|P-value:7.30E-8 ID:SGTC_1242|Compound:0402-0103|FD-Score:5.34|P-value:5.72E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:13.00|P-value:1.11E-32 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.06|P-value:1.09E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.99|P-value:1.35E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.77|P-value:6.93E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.47|P-value:2.35E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.58|P-value:1.80E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-4.75|P-value:7.44E-6 ID:SGTC_1635|Compound:st007035|FD-Score:4.49|P-value:2.12E-5 ID:SGTC_1661|Compound:st013063|FD-Score:4.59|P-value:1.45E-5 ID:SGTC_1672|Compound:st016598|FD-Score:4.95|P-value:3.19E-6 ID:SGTC_1696|Compound:st025591|FD-Score:12.50|P-value:2.59E-30 ID:SGTC_1709|Compound:st033179|FD-Score:-3.66|P-value:4.21E-4 ID:SGTC_1723|Compound:st034307|FD-Score:5.51|P-value:2.52E-7 ID:SGTC_1786|Compound:berberine|FD-Score:4.49|P-value:2.14E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:20.70|P-value:7.36E-80 ID:SGTC_1919|Compound:st067113|FD-Score:4.29|P-value:4.57E-5 ID:SGTC_2004|Compound:4023728|FD-Score:9.61|P-value:1.01E-18 ID:SGTC_2011|Compound:4012611|FD-Score:-3.89|P-value:1.98E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.71|P-value:3.55E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.41|P-value:9.35E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:12.90|P-value:2.17E-32 ID:SGTC_2246|Compound:7293507|FD-Score:4.39|P-value:3.13E-5 ID:SGTC_2323|Compound:6148992|FD-Score:3.93|P-value:1.69E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.61|P-value:5.08E-4 ID:SGTC_2354|Compound:9060492|FD-Score:5.04|P-value:2.21E-6 ID:SGTC_2356|Compound:9061756|FD-Score:3.79|P-value:2.76E-4 ID:SGTC_2376|Compound:9072922|FD-Score:7.28|P-value:1.62E-11 ID:SGTC_2384|Compound:9036245|FD-Score:5.41|P-value:4.02E-7 ID:SGTC_2387|Compound:9077560|FD-Score:-5.24|P-value:8.84E-7 ID:SGTC_2389|Compound:9091542|FD-Score:-4.53|P-value:1.83E-5 ID:SGTC_2390|Compound:9097792|FD-Score:4.52|P-value:1.89E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.36|P-value:3.55E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.35|P-value:3.58E-9 ID:SGTC_2430|Compound:5571206|FD-Score:13.30|P-value:2.81E-34 ID:SGTC_2453|Compound:5731132|FD-Score:3.78|P-value:2.81E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:7.75|P-value:7.83E-13 ID:SGTC_2651|Compound:1327-0036|FD-Score:16.40|P-value:5.69E-51 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.50|P-value:3.72E-30 ID:SGTC_2689|Compound:tacrolimus|FD-Score:16.40|P-value:6.90E-51 ID:SGTC_2694|Compound:st077685|FD-Score:12.80|P-value:1.06E-31 ID:SGTC_2813|Compound:7971799|FD-Score:3.53|P-value:6.37E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-3.62|P-value:4.85E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.98|P-value:1.42E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.59|P-value:5.38E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.68|P-value:3.95E-4 ID:SGTC_2849|Compound:9019321|FD-Score:5.21|P-value:1.03E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-3.41|P-value:9.49E-4 ID:SGTC_2921|Compound:7974240|FD-Score:5.05|P-value:2.04E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.84|P-value:2.34E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.00|P-value:1.31E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.62|P-value:4.78E-4 ID:SGTC_3328|Compound:9140624|FD-Score:5.64|P-value:1.35E-7 ID:SGTC_3347|Compound:9188721|FD-Score:14.60|P-value:8.93E-41 ID:SGTC_3353|Compound:9151644|FD-Score:5.07|P-value:1.92E-6 ID:SGTC_7|Compound:0192-1582|FD-Score:8.96|P-value:1.61E-16 ID:SGTC_18|Compound:0111-0177|FD-Score:4.13|P-value:8.39E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:4.05|P-value:1.12E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:8.76|P-value:7.17E-16 ID:SGTC_46|Compound:0329-0187a|FD-Score:8.67|P-value:1.31E-15 ID:SGTC_59|Compound:0330-0160|FD-Score:9.15|P-value:3.64E-17 ID:SGTC_73|Compound:0327-0325|FD-Score:8.01|P-value:1.39E-13 ID:SGTC_81|Compound:0411-0046|FD-Score:7.52|P-value:3.48E-12 ID:SGTC_84|Compound:0443-0269|FD-Score:4.18|P-value:6.91E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:8.50|P-value:4.74E-15 ID:SGTC_90|Compound:0870-0863|FD-Score:10.60|P-value:1.68E-22 ID:SGTC_96|Compound:0929-0093|FD-Score:5.40|P-value:4.28E-7 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:12.20|P-value:4.88E-29 ID:SGTC_127|Compound:0180-0333|FD-Score:4.39|P-value:3.16E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.82|P-value:2.48E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.77|P-value:2.92E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:7.35|P-value:1.01E-11 ID:SGTC_150|Compound:3970-0969|FD-Score:6.40|P-value:2.67E-9 ID:SGTC_159|Compound:3970-0959|FD-Score:9.50|P-value:2.30E-18 ID:SGTC_163|Compound:1327-0036|FD-Score:18.80|P-value:3.92E-66 ID:SGTC_168|Compound:3970-0862|FD-Score:10.10|P-value:1.19E-20 ID:SGTC_177|Compound:1327-0068|FD-Score:6.94|P-value:1.25E-10 ID:SGTC_181|Compound:1447-1644|FD-Score:3.87|P-value:2.13E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:18.20|P-value:2.25E-62 ID:SGTC_210|Compound:3551-0445|FD-Score:3.84|P-value:2.28E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:12.60|P-value:1.00E-30 ID:SGTC_235|Compound:0330-0087|FD-Score:4.09|P-value:9.78E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:8.60|P-value:2.33E-15 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.87|P-value:2.10E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:9.68|P-value:5.68E-19 ID:SGTC_260|Compound:nsc-65238|FD-Score:8.17|P-value:4.60E-14 ID:SGTC_274|Compound:sirtinol|FD-Score:3.92|P-value:1.74E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.52|P-value:6.71E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.66|P-value:4.19E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.88|P-value:2.01E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.75|P-value:3.20E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.69|P-value:3.86E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:24.10|P-value:2.47E-107 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.96|P-value:1.52E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:10.40|P-value:1.37E-21 ID:SGTC_386|Compound:1509-0011|FD-Score:7.95|P-value:2.17E-13 ID:SGTC_428|Compound:3448-4153|FD-Score:3.43|P-value:8.72E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.56|P-value:1.58E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-4.69|P-value:9.75E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:7.03|P-value:7.16E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.35|P-value:5.30E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.59|P-value:2.30E-12 ID:SGTC_492|Compound:tmb-8|FD-Score:17.90|P-value:5.68E-60 ID:SGTC_513|Compound:4245-1575|FD-Score:13.30|P-value:5.62E-34 ID:SGTC_564|Compound:3555-0129|FD-Score:3.67|P-value:4.12E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.42|P-value:2.75E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.53|P-value:6.41E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.93|P-value:3.44E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:12.60|P-value:5.11E-31 ID:SGTC_718|Compound:1130-0073|FD-Score:4.24|P-value:5.47E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:4.77|P-value:6.83E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:3.50|P-value:7.19E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.01|P-value:2.51E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.42|P-value:9.18E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.67|P-value:1.01E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.79|P-value:2.78E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:14.50|P-value:2.78E-40 ID:SGTC_975|Compound:1335-0046|FD-Score:3.94|P-value:1.66E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.44|P-value:8.67E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:4.92|P-value:3.66E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:6.15|P-value:1.01E-8 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.52|P-value:6.73E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.85|P-value:2.22E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:8.45|P-value:6.56E-15 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.83|P-value:2.40E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.03|P-value:1.18E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.58|P-value:5.54E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.99|P-value:1.37E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:18.70|P-value:1.83E-65 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.40|P-value:3.04E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.67|P-value:4.19E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.13|P-value:8.36E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.77|P-value:7.30E-8 ID:SGTC_1242|Compound:0402-0103|FD-Score:5.34|P-value:5.72E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:13.00|P-value:1.11E-32 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.06|P-value:1.09E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.99|P-value:1.35E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.77|P-value:6.93E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.47|P-value:2.35E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.58|P-value:1.80E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-4.75|P-value:7.44E-6 ID:SGTC_1635|Compound:st007035|FD-Score:4.49|P-value:2.12E-5 ID:SGTC_1661|Compound:st013063|FD-Score:4.59|P-value:1.45E-5 ID:SGTC_1672|Compound:st016598|FD-Score:4.95|P-value:3.19E-6 ID:SGTC_1696|Compound:st025591|FD-Score:12.50|P-value:2.59E-30 ID:SGTC_1709|Compound:st033179|FD-Score:-3.66|P-value:4.21E-4 ID:SGTC_1723|Compound:st034307|FD-Score:5.51|P-value:2.52E-7 ID:SGTC_1786|Compound:berberine|FD-Score:4.49|P-value:2.14E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:20.70|P-value:7.36E-80 ID:SGTC_1919|Compound:st067113|FD-Score:4.29|P-value:4.57E-5 ID:SGTC_2004|Compound:4023728|FD-Score:9.61|P-value:1.01E-18 ID:SGTC_2011|Compound:4012611|FD-Score:-3.89|P-value:1.98E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.71|P-value:3.55E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.41|P-value:9.35E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:12.90|P-value:2.17E-32 ID:SGTC_2246|Compound:7293507|FD-Score:4.39|P-value:3.13E-5 ID:SGTC_2323|Compound:6148992|FD-Score:3.93|P-value:1.69E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.61|P-value:5.08E-4 ID:SGTC_2354|Compound:9060492|FD-Score:5.04|P-value:2.21E-6 ID:SGTC_2356|Compound:9061756|FD-Score:3.79|P-value:2.76E-4 ID:SGTC_2376|Compound:9072922|FD-Score:7.28|P-value:1.62E-11 ID:SGTC_2384|Compound:9036245|FD-Score:5.41|P-value:4.02E-7 ID:SGTC_2387|Compound:9077560|FD-Score:-5.24|P-value:8.84E-7 ID:SGTC_2389|Compound:9091542|FD-Score:-4.53|P-value:1.83E-5 ID:SGTC_2390|Compound:9097792|FD-Score:4.52|P-value:1.89E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.36|P-value:3.55E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.35|P-value:3.58E-9 ID:SGTC_2430|Compound:5571206|FD-Score:13.30|P-value:2.81E-34 ID:SGTC_2453|Compound:5731132|FD-Score:3.78|P-value:2.81E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:7.75|P-value:7.83E-13 ID:SGTC_2651|Compound:1327-0036|FD-Score:16.40|P-value:5.69E-51 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.50|P-value:3.72E-30 ID:SGTC_2689|Compound:tacrolimus|FD-Score:16.40|P-value:6.90E-51 ID:SGTC_2694|Compound:st077685|FD-Score:12.80|P-value:1.06E-31 ID:SGTC_2813|Compound:7971799|FD-Score:3.53|P-value:6.37E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-3.62|P-value:4.85E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.98|P-value:1.42E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.59|P-value:5.38E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.68|P-value:3.95E-4 ID:SGTC_2849|Compound:9019321|FD-Score:5.21|P-value:1.03E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-3.41|P-value:9.49E-4 ID:SGTC_2921|Compound:7974240|FD-Score:5.05|P-value:2.04E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.84|P-value:2.34E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.00|P-value:1.31E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.62|P-value:4.78E-4 ID:SGTC_3328|Compound:9140624|FD-Score:5.64|P-value:1.35E-7 ID:SGTC_3347|Compound:9188721|FD-Score:14.60|P-value:8.93E-41 ID:SGTC_3353|Compound:9151644|FD-Score:5.07|P-value:1.92E-6

Top fitness defect scores for YJR139C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_363 0455-0021 24.10 3.1 µM 2.47E-107 azole & statin 1 1.02E-128
2 SGTC_1844 rapamycin 20.70 4.0 nM 7.36E-80 5 1.16E-95
3 SGTC_163 1327-0036 18.80 7.5 µM 3.92E-66 4 3.76E-79
4 SGTC_1130 3454-2858 18.70 15.9 µM 1.83E-65 NEO1 6 2.39E-78
5 SGTC_195 4234-0266 18.20 16.6 µM 2.25E-62 1 1.25E-74
6 SGTC_492 tmb-8 17.90 126.0 µM 5.68E-60 1 9.69E-72
7 SGTC_2651 1327-0036 16.40 5.0 µM 5.69E-51 3 6.49E-61
8 SGTC_2689 tacrolimus 16.40 100.0 µM 6.90E-51 1 8.17E-61
9 SGTC_3347 9188721 14.60 44.7 µM 8.93E-41 1 1.18E-48
10 SGTC_924 2046-0044 14.50 21.3 µM 2.78E-40 1 4.63E-48
11 SGTC_2430 5571206 13.30 200.0 µM 2.81E-34 3 7.68E-41
12 SGTC_513 4245-1575 13.30 41.7 µM 5.62E-34 unfolded protein response 7 1.77E-40
13 SGTC_1249 0481-0015 13.00 10.2 µM 1.11E-32 2 6.38E-39
14 SGTC_2233 sulbentine 12.90 40.4 µM 2.17E-32 4 1.43E-38
15 SGTC_2694 st077685 12.80 81.9 µM 1.06E-31 endomembrane recycling 3 9.57E-38
16 SGTC_690 glyoxal 12.60 20.3 µM 5.11E-31 9 6.37E-37
17 SGTC_214 4373-3496 12.60 70.0 µM 1.00E-30 1 1.43E-36
18 SGTC_1696 st025591 12.50 34.8 µM 2.59E-30 SWF1 & branched chain AA biosynthesis 2 4.47E-36
19 SGTC_2679 rapamycin 12.50 1.0 nM 3.72E-30 14 6.93E-36
20 SGTC_120 rhodamine 6G 12.20 52.3 µM 4.88E-29 mitochondrial processes 3 1.53E-34

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.502 7.18E-213 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.418 1.30E-141 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.372 1.67E-110 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.354 2.35E-99 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.289 2.02E-65 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.285 1.10E-63 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.274 1.76E-58 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.259 2.52E-52 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.251 3.85E-49 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.249 2.70E-48 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.243 4.81E-46 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.225 1.46E-39 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.222 1.34E-38 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.212 2.35E-35 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.209 2.59E-34 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p