YKL016C / ATP7

Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL016C / ATP7

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:4.17|P-value:2.32E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:5.47|P-value:4.48E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:4.11|P-value:3.00E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.61|P-value:2.13E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.19|P-value:8.59E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.42|P-value:4.11E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-7.96|P-value:3.01E-15 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.37|P-value:4.65E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.67|P-value:1.68E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:19.90|P-value:3.53E-85 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.16|P-value:2.30E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:7.93|P-value:4.36E-15 ID:SGTC_314|Compound:1671-0008|FD-Score:4.64|P-value:2.89E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.02|P-value:3.95E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.37|P-value:5.05E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.30|P-value:6.43E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.91|P-value:7.33E-7 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_480|Compound:am 92016|FD-Score:4.23|P-value:1.81E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.75|P-value:1.18E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.43|P-value:3.79E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.17|P-value:9.82E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.59|P-value:3.60E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:3.41|P-value:4.29E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.81|P-value:6.78E-9 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.60|P-value:2.17E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.34|P-value:5.25E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.49|P-value:3.21E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.23|P-value:8.04E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.42|P-value:4.20E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.17|P-value:2.28E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-3.21|P-value:8.23E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.37|P-value:5.04E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.59|P-value:2.10E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-5.13|P-value:2.44E-7 ID:SGTC_2132|Compound:5317594|FD-Score:-3.38|P-value:4.61E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.68|P-value:2.90E-14 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.56|P-value:4.05E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.26|P-value:7.34E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:5.02|P-value:4.65E-7 ID:SGTC_2727|Compound:riluzole|FD-Score:4.13|P-value:2.71E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.25|P-value:7.06E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.61|P-value:2.06E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.70|P-value:1.52E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.21|P-value:8.07E-4 ID:SGTC_2894|Compound:9048625|FD-Score:4.24|P-value:1.70E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-7.81|P-value:9.33E-15 ID:SGTC_2952|Compound:9073731|FD-Score:3.83|P-value:9.03E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.24|P-value:7.87E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.46|P-value:3.36E-4 ID:SGTC_3106|Compound:9121286|FD-Score:6.24|P-value:5.09E-10 ID:SGTC_3109|Compound:9122853|FD-Score:3.53|P-value:2.81E-4 ID:SGTC_3110|Compound:9122132|FD-Score:-5.56|P-value:2.54E-8 ID:SGTC_3112|Compound:9123419|FD-Score:6.00|P-value:2.23E-9 ID:SGTC_3113|Compound:9123498|FD-Score:4.99|P-value:5.40E-7 ID:SGTC_3117|Compound:9124945|FD-Score:3.92|P-value:6.41E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.53|P-value:2.78E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.30|P-value:5.98E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.17|P-value:2.32E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:5.47|P-value:4.48E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:4.11|P-value:3.00E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.61|P-value:2.13E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.19|P-value:8.59E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.42|P-value:4.11E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-7.96|P-value:3.01E-15 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.37|P-value:4.65E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.67|P-value:1.68E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:19.90|P-value:3.53E-85 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.16|P-value:2.30E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:7.93|P-value:4.36E-15 ID:SGTC_314|Compound:1671-0008|FD-Score:4.64|P-value:2.89E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.02|P-value:3.95E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.37|P-value:5.05E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.30|P-value:6.43E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.91|P-value:7.33E-7 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_480|Compound:am 92016|FD-Score:4.23|P-value:1.81E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.75|P-value:1.18E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.43|P-value:3.79E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.17|P-value:9.82E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.59|P-value:3.60E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:3.41|P-value:4.29E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.81|P-value:6.78E-9 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.60|P-value:2.17E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.34|P-value:5.25E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.49|P-value:3.21E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.23|P-value:8.04E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.42|P-value:4.20E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.17|P-value:2.28E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-3.21|P-value:8.23E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.37|P-value:5.04E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.59|P-value:2.10E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-5.13|P-value:2.44E-7 ID:SGTC_2132|Compound:5317594|FD-Score:-3.38|P-value:4.61E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.68|P-value:2.90E-14 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.56|P-value:4.05E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.26|P-value:7.34E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:5.02|P-value:4.65E-7 ID:SGTC_2727|Compound:riluzole|FD-Score:4.13|P-value:2.71E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.25|P-value:7.06E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.61|P-value:2.06E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.70|P-value:1.52E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.21|P-value:8.07E-4 ID:SGTC_2894|Compound:9048625|FD-Score:4.24|P-value:1.70E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-7.81|P-value:9.33E-15 ID:SGTC_2952|Compound:9073731|FD-Score:3.83|P-value:9.03E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.24|P-value:7.87E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.46|P-value:3.36E-4 ID:SGTC_3106|Compound:9121286|FD-Score:6.24|P-value:5.09E-10 ID:SGTC_3109|Compound:9122853|FD-Score:3.53|P-value:2.81E-4 ID:SGTC_3110|Compound:9122132|FD-Score:-5.56|P-value:2.54E-8 ID:SGTC_3112|Compound:9123419|FD-Score:6.00|P-value:2.23E-9 ID:SGTC_3113|Compound:9123498|FD-Score:4.99|P-value:5.40E-7 ID:SGTC_3117|Compound:9124945|FD-Score:3.92|P-value:6.41E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.53|P-value:2.78E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.30|P-value:5.98E-4

Top fitness defect scores for YKL016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 19.90 5.3 µM 3.53E-85 54 8.54E-89
2 SGTC_310 1273-0058 7.93 1.1 µM 4.36E-15 mitochondrial stress 92 1.11E-15
3 SGTC_2250 alverine citrate 7.68 130.0 µM 2.90E-14 23 7.99E-15
4 SGTC_3106 9121286 6.24 49.5 µM 5.09E-10 1 2.13E-10
5 SGTC_3112 9123419 6.00 49.5 µM 2.23E-9 RPP1 & pyrimidine depletion 1 9.95E-10
6 SGTC_908 3448-7491 5.81 47.7 µM 6.78E-9 mitochondrial stress 54 3.18E-9
7 SGTC_87 0100-0052 5.47 35.5 µM 4.48E-8 41 2.27E-8
8 SGTC_275 trichlorophene 5.16 5.7 µM 2.30E-7 mitochondrial stress 158 1.26E-7
9 SGTC_2630 antimycin a 5.02 100.0 µM 4.65E-7 mitochondrial processes 18 2.61E-7
10 SGTC_3113 9123498 4.99 49.5 µM 5.40E-7 4 3.05E-7
11 SGTC_314 1671-0008 4.64 2.7 µM 2.89E-6 28 1.76E-6
12 SGTC_767 0929-0023 4.59 86.0 µM 3.60E-6 TRP & mitochondrial translation 48 2.21E-6
13 SGTC_2520 obtusaquinone 4.56 4.7 µM 4.05E-6 9 2.50E-6
14 SGTC_2894 9048625 4.24 32.5 µM 1.70E-5 5 1.11E-5
15 SGTC_480 am 92016 4.23 50.0 µM 1.81E-5 8 1.19E-5
16 SGTC_1680 diphenhydramine 4.17 100.0 µM 2.28E-5 NEO1 22 1.51E-5
17 SGTC_46 0329-0187a 4.17 2.2 µM 2.32E-5 65 1.54E-5
18 SGTC_2727 riluzole 4.13 51.8 µM 2.71E-5 mitochondrial processes 13 1.81E-5
19 SGTC_118 0083-0097 4.11 135.3 µM 3.00E-5 translation 117 2.01E-5
20 SGTC_3117 9124945 3.92 49.5 µM 6.41E-5 5 4.45E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.502 2.11E-213 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.500 1.58E-211 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.480 1.52E-192 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.478 1.33E-191 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.471 1.05E-184 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.463 4.47E-178 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.452 1.58E-167 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.450 7.33E-167 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.444 2.04E-162 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.441 2.64E-159 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.437 2.95E-156 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.435 3.83E-155 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.430 3.07E-151 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.429 1.35E-150 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.429 3.87E-150 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria