HIPHOP chemogenomics database

YKL016C / ATP7

Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis

Zygosity: Homozygous strain

fixedexpanded
Profile for YKL016C / ATP7

Click on Significant Values for Screen Details

Top fitness defect scores for YKL016C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	19.90	5.3 µM	3.53E-85		54	8.54E-89
2	SGTC_310	1273-0058	7.93	1.1 µM	4.36E-15	mitochondrial stress	92	1.11E-15
3	SGTC_2250	alverine citrate	7.68	130.0 µM	2.90E-14		23	7.99E-15
4	SGTC_3106	9121286	6.24	49.5 µM	5.09E-10		1	2.13E-10
5	SGTC_3112	9123419	6.00	49.5 µM	2.23E-9	RPP1 & pyrimidine depletion	1	9.95E-10
6	SGTC_908	3448-7491	5.81	47.7 µM	6.78E-9	mitochondrial stress	54	3.18E-9
7	SGTC_87	0100-0052	5.47	35.5 µM	4.48E-8		41	2.27E-8
8	SGTC_275	trichlorophene	5.16	5.7 µM	2.30E-7	mitochondrial stress	158	1.26E-7
9	SGTC_2630	antimycin a	5.02	100.0 µM	4.65E-7	mitochondrial processes	18	2.61E-7
10	SGTC_3113	9123498	4.99	49.5 µM	5.40E-7		4	3.05E-7
11	SGTC_314	1671-0008	4.64	2.7 µM	2.89E-6		28	1.76E-6
12	SGTC_767	0929-0023	4.59	86.0 µM	3.60E-6	TRP & mitochondrial translation	48	2.21E-6
13	SGTC_2520	obtusaquinone	4.56	4.7 µM	4.05E-6		9	2.50E-6
14	SGTC_2894	9048625	4.24	32.5 µM	1.70E-5		5	1.11E-5
15	SGTC_480	am 92016	4.23	50.0 µM	1.81E-5		8	1.19E-5
16	SGTC_1680	diphenhydramine	4.17	100.0 µM	2.28E-5	NEO1	22	1.51E-5
17	SGTC_46	0329-0187a	4.17	2.2 µM	2.32E-5		65	1.54E-5
18	SGTC_2727	riluzole	4.13	51.8 µM	2.71E-5	mitochondrial processes	13	1.81E-5
19	SGTC_118	0083-0097	4.11	135.3 µM	3.00E-5	translation	117	2.01E-5
20	SGTC_3117	9124945	3.92	49.5 µM	6.41E-5		5	4.45E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.502	2.11E-213	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.500	1.58E-211	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.480	1.52E-192	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.478	1.33E-191	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.471	1.05E-184	YMR286W	MRPL33	hom	Mitochondrial ribosomal protein of the large subunit
0.463	4.47E-178	YDR079W	PET100	hom	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.452	1.58E-167	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.450	7.33E-167	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.444	2.04E-162	YLL033W	IRC19	hom	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.441	2.64E-159	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.437	2.95E-156	YMR098C	ATP25	hom	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.435	3.83E-155	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.430	3.07E-151	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.429	1.35E-150	YML129C	COX14	hom	Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.429	3.87E-150	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria