HIPHOP chemogenomics database
YKL017C / HCS1 
Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YKL017C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.147 | 1.42E-17 | YFL044C | OTU1 | hom | Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress |
| 0.115 | 2.07E-11 | YKL179C | COY1 | hom | Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function |
| 0.108 | 3.10E-10 | YER148W | SPT15 | het | TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability |
| 0.108 | 4.06E-10 | YHL007C | STE20 | hom | Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p |
| 0.103 | 2.58E-9 | YBL050W | SEC17 | het | Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP |
| 0.098 | 1.13E-8 | YDR421W | ARO80 | hom | Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids |
| 0.090 | 1.71E-7 | YMR167W | MLH1 | hom | Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer |
| 0.089 | 2.74E-7 | YHR123W | EPT1 | hom | sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication |
| 0.088 | 3.34E-7 | YMR020W | FMS1 | hom | Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis |
| 0.087 | 3.99E-7 | YDR210W_p | YDR210W_p | hom | Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
| 0.085 | 7.26E-7 | YGR154C | GTO1 | hom | Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization |
| 0.084 | 1.01E-6 | YDR286C_p | YDR286C_p | hom | Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site |
| 0.084 | 1.27E-6 | YOR302W | YOR302W | hom | CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA |
| 0.083 | 1.50E-6 | YKL147C_d | YKL147C_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3 |
| 0.083 | 1.66E-6 | YFL052W_p | YFL052W_p | hom | Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity |