YKL030W_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL030W / YKL030W

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.41|P-value:1.07E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.02|P-value:5.30E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.88|P-value:1.05E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:3.05|P-value:4.75E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.59|P-value:4.83E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.90|P-value:9.59E-6 ID:SGTC_836|Compound:0330-0104|FD-Score:3.22|P-value:2.37E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.82|P-value:1.36E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:3.78|P-value:2.02E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:4.53|P-value:4.31E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.06|P-value:4.23E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.32|P-value:1.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.84|P-value:1.24E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.32|P-value:1.58E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.92|P-value:7.81E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-3.57|P-value:4.46E-5 ID:SGTC_1563|Compound:conessine|FD-Score:4.83|P-value:7.60E-8 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:6.20|P-value:7.48E-12 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.00|P-value:5.78E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.29|P-value:1.77E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.98|P-value:6.31E-6 ID:SGTC_1661|Compound:st013063|FD-Score:-3.14|P-value:2.79E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-2.95|P-value:6.03E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.85|P-value:9.92E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.67|P-value:3.32E-5 ID:SGTC_2197|Compound:6588183|FD-Score:3.18|P-value:2.79E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.32|P-value:1.57E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.71|P-value:2.76E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.42|P-value:1.02E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.15|P-value:3.19E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.70|P-value:2.93E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.04|P-value:5.81E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.21|P-value:7.25E-9 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.62|P-value:4.18E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-3.06|P-value:3.94E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.14|P-value:3.33E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.25|P-value:1.78E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:2.92|P-value:7.59E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.21|P-value:2.46E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.22|P-value:2.40E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.37|P-value:1.27E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-2.93|P-value:6.45E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.05|P-value:5.41E-6 ID:SGTC_37|Compound:0566-0070|FD-Score:3.41|P-value:1.07E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.02|P-value:5.30E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.88|P-value:1.05E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:3.05|P-value:4.75E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.59|P-value:4.83E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.90|P-value:9.59E-6 ID:SGTC_836|Compound:0330-0104|FD-Score:3.22|P-value:2.37E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.82|P-value:1.36E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:3.78|P-value:2.02E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:4.53|P-value:4.31E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.06|P-value:4.23E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.32|P-value:1.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.84|P-value:1.24E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.32|P-value:1.58E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.92|P-value:7.81E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-3.57|P-value:4.46E-5 ID:SGTC_1563|Compound:conessine|FD-Score:4.83|P-value:7.60E-8 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:6.20|P-value:7.48E-12 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.00|P-value:5.78E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.29|P-value:1.77E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.98|P-value:6.31E-6 ID:SGTC_1661|Compound:st013063|FD-Score:-3.14|P-value:2.79E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-2.95|P-value:6.03E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.85|P-value:9.92E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.67|P-value:3.32E-5 ID:SGTC_2197|Compound:6588183|FD-Score:3.18|P-value:2.79E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.32|P-value:1.57E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.71|P-value:2.76E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.42|P-value:1.02E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.15|P-value:3.19E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.70|P-value:2.93E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.04|P-value:5.81E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.21|P-value:7.25E-9 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.62|P-value:4.18E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-3.06|P-value:3.94E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.14|P-value:3.33E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.25|P-value:1.78E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:2.92|P-value:7.59E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.21|P-value:2.46E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.22|P-value:2.40E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.37|P-value:1.27E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-2.93|P-value:6.45E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.05|P-value:5.41E-6

Top fitness defect scores for YKL030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 6.20 85.4 µM 7.48E-12 3 2.80E-10
2 SGTC_2419 paclitaxel 5.21 166.5 µM 7.25E-9 11 9.39E-8
3 SGTC_1563 conessine 4.83 56.1 µM 7.60E-8 5 6.87E-7
4 SGTC_883 0850-0245 4.53 24.6 µM 4.31E-7 cell wall 21 2.99E-6
5 SGTC_3225 9130819 4.05 49.5 µM 5.41E-6 amide catabolism 26 2.56E-5
6 SGTC_2408 sulbentine 4.04 18.4 µM 5.81E-6 47 2.72E-5
7 SGTC_875 0709-0210 3.78 25.7 µM 2.02E-5 fatty acid desaturase (OLE1) 36 7.83E-5
8 SGTC_2343 7990716 3.71 14.8 µM 2.76E-5 25 1.02E-4
9 SGTC_2356 9061756 3.70 189.0 µM 2.93E-5 13 1.08E-4
10 SGTC_2002 4023503 3.67 131.0 µM 3.32E-5 mitochondrial processes 41 1.20E-4
11 SGTC_2514 salinomycin 3.62 42.7 µM 4.18E-5 63 1.46E-4
12 SGTC_597 k018-0003 3.59 82.8 µM 4.83E-5 RNA pol III & RNase P/MRP 17 1.65E-4
13 SGTC_2344 7990960 3.42 77.0 µM 1.02E-4 42 3.10E-4
14 SGTC_37 0566-0070 3.41 1.6 µM 1.07E-4 48 3.24E-4
15 SGTC_2978 9011784 3.37 43.0 µM 1.27E-4 54 3.76E-4
16 SGTC_2217 6934799 3.32 96.1 µM 1.57E-4 TSC3-RPN4 13 4.49E-4
17 SGTC_915 methyl methanesulfonate (MMS) 3.32 110.0 mM 1.57E-4 DNA damage response 67 4.50E-4
18 SGTC_1118 chelidonine 3.32 707.5 nM 1.58E-4 38 4.51E-4
19 SGTC_1572 epiandrosterone 3.29 68.9 µM 1.77E-4 51 4.98E-4
20 SGTC_836 0330-0104 3.22 1.4 µM 2.37E-4 35 6.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 1.28E-38 YGR201C_p YGR201C_p hom Putative protein of unknown function
0.209 1.46E-34 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.207 8.55E-34 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
0.202 2.40E-32 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.173 5.52E-24 YDR306C_p YDR306C_p hom F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
0.160 1.04E-20 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.153 4.29E-19 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.151 1.38E-18 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.150 1.82E-18 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.146 1.96E-17 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.136 2.86E-15 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.133 1.03E-14 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.131 2.13E-14 YBL002W HTB2 hom Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.130 4.73E-14 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.128 1.20E-13 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family