YKL043W / PHD1

Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL043W / PHD1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:4.81|P-value:7.63E-8 ID:SGTC_269|Compound:exalamide|FD-Score:3.63|P-value:3.64E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.25|P-value:1.89E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:2.84|P-value:9.33E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.13|P-value:3.08E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.55|P-value:5.14E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:5.17|P-value:8.64E-9 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.71|P-value:3.30E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:5.14|P-value:1.04E-8 ID:SGTC_734|Compound:2023-0417|FD-Score:2.89|P-value:7.86E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.20|P-value:2.97E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.74|P-value:2.22E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:3.86|P-value:1.26E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.28|P-value:1.68E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.95|P-value:1.09E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.05|P-value:4.25E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.53|P-value:5.79E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.59|P-value:4.34E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:-2.96|P-value:7.58E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.30|P-value:1.53E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.05|P-value:4.16E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.36|P-value:1.18E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.81|P-value:1.14E-7 ID:SGTC_1717|Compound:st033143|FD-Score:5.59|P-value:5.75E-10 ID:SGTC_1758|Compound:st042942|FD-Score:3.45|P-value:8.09E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.64|P-value:3.52E-5 ID:SGTC_1854|Compound:st056233|FD-Score:3.31|P-value:1.47E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.18|P-value:3.19E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.37|P-value:1.16E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.37|P-value:1.12E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.13|P-value:3.20E-6 ID:SGTC_2090|Compound:5301565|FD-Score:3.01|P-value:4.95E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-2.93|P-value:8.30E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.08|P-value:3.71E-4 ID:SGTC_2248|Compound:tofa|FD-Score:2.86|P-value:8.59E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.11|P-value:3.28E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.83|P-value:1.45E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.96|P-value:4.56E-8 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.95|P-value:3.45E-8 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.55|P-value:7.27E-10 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.15|P-value:2.84E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.59|P-value:5.73E-5 ID:SGTC_3052|Compound:9092717|FD-Score:-3.66|P-value:4.24E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.16|P-value:2.76E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.12|P-value:4.15E-4 ID:SGTC_3235|Compound:9132602|FD-Score:2.89|P-value:7.63E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.24|P-value:2.54E-4 ID:SGTC_3335|Compound:9143315|FD-Score:2.97|P-value:5.68E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.81|P-value:7.63E-8 ID:SGTC_269|Compound:exalamide|FD-Score:3.63|P-value:3.64E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.25|P-value:1.89E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:2.84|P-value:9.33E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.13|P-value:3.08E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.55|P-value:5.14E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:5.17|P-value:8.64E-9 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.71|P-value:3.30E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:5.14|P-value:1.04E-8 ID:SGTC_734|Compound:2023-0417|FD-Score:2.89|P-value:7.86E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.20|P-value:2.97E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.74|P-value:2.22E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:3.86|P-value:1.26E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.28|P-value:1.68E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.95|P-value:1.09E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.05|P-value:4.25E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.53|P-value:5.79E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.59|P-value:4.34E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:-2.96|P-value:7.58E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.30|P-value:1.53E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.05|P-value:4.16E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.36|P-value:1.18E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.81|P-value:1.14E-7 ID:SGTC_1717|Compound:st033143|FD-Score:5.59|P-value:5.75E-10 ID:SGTC_1758|Compound:st042942|FD-Score:3.45|P-value:8.09E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.64|P-value:3.52E-5 ID:SGTC_1854|Compound:st056233|FD-Score:3.31|P-value:1.47E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.18|P-value:3.19E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.37|P-value:1.16E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.37|P-value:1.12E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.13|P-value:3.20E-6 ID:SGTC_2090|Compound:5301565|FD-Score:3.01|P-value:4.95E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-2.93|P-value:8.30E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.08|P-value:3.71E-4 ID:SGTC_2248|Compound:tofa|FD-Score:2.86|P-value:8.59E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.11|P-value:3.28E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.83|P-value:1.45E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.96|P-value:4.56E-8 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.95|P-value:3.45E-8 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.55|P-value:7.27E-10 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.15|P-value:2.84E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.59|P-value:5.73E-5 ID:SGTC_3052|Compound:9092717|FD-Score:-3.66|P-value:4.24E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.16|P-value:2.76E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.12|P-value:4.15E-4 ID:SGTC_3235|Compound:9132602|FD-Score:2.89|P-value:7.63E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.24|P-value:2.54E-4 ID:SGTC_3335|Compound:9143315|FD-Score:2.97|P-value:5.68E-4

Top fitness defect scores for YKL043W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1717 st033143 5.59 58.0 µM 5.75E-10 15 1.15E-8
2 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 5.55 100.0 µM 7.27E-10 8 1.41E-8
3 SGTC_672 1441-0018 5.17 53.7 µM 8.64E-9 3 1.16E-7
4 SGTC_687 k029-0044 5.14 34.9 µM 1.04E-8 PDR1 7 1.36E-7
5 SGTC_2598 perillyl alcohol 4.95 100.0 µM 3.45E-8 12 3.76E-7
6 SGTC_50 0929-0078 4.81 56.4 µM 7.63E-8 32 7.40E-7
7 SGTC_2042 p-Dimethylaminoacetophenone 4.13 200.0 µM 3.20E-6 12 1.78E-5
8 SGTC_940 3232-1287 3.86 54.8 µM 1.26E-5 NEO1 43 5.75E-5
9 SGTC_2592 piperlongumine 3.83 83.3 µM 1.45E-5 TSC3-RPN4 46 6.44E-5
10 SGTC_799 1310-0557 3.74 151.0 µM 2.22E-5 superoxide 29 9.30E-5
11 SGTC_1820 st053765 3.64 18.6 µM 3.52E-5 RPP1 & pyrimidine depletion 27 1.38E-4
12 SGTC_269 exalamide 3.63 29.0 µM 3.64E-5 ergosterol biosynthesis 25 1.41E-4
13 SGTC_1098 clofazimine 3.59 15.1 µM 4.34E-5 heme biosynthesis & mitochondrial translocase 40 1.65E-4
14 SGTC_662 k832-1615 3.55 104.0 µM 5.14E-5 31 1.90E-4
15 SGTC_1047 2043-3044 3.53 82.0 µM 5.79E-5 54 2.10E-4
16 SGTC_1758 st042942 3.45 75.2 µM 8.09E-5 35 2.80E-4
17 SGTC_1960 st011366 3.37 51.8 µM 1.12E-4 25 3.70E-4
18 SGTC_1875 nocodazole 3.37 6.0 µM 1.16E-4 tubulin folding & SWR complex 61 3.81E-4
19 SGTC_1661 st013063 3.36 9.7 µM 1.18E-4 43 3.85E-4
20 SGTC_1854 st056233 3.31 32.9 µM 1.47E-4 amide catabolism 37 4.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.43E-13 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.112 7.31E-11 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.109 2.21E-10 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.101 4.97E-9 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.100 6.11E-9 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.098 1.37E-8 YMR244W_p YMR244W_p hom Putative protein of unknown function
0.094 5.12E-8 YGR179C OKP1 het Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
0.092 1.00E-7 YPL149W ATG5 hom Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
0.087 3.91E-7 YJL060W BNA3 hom Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
0.087 4.00E-7 YOL013W-B_d YOL013W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element
0.084 1.00E-6 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.083 1.65E-6 YDL241W_p YDL241W_p hom Putative protein of unknown function; YDL241W is not an essential gene
0.079 4.12E-6 YML054C-A_p YML054C-A_p hom Putative protein of unknown function
0.079 4.60E-6 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.078 6.55E-6 YLL061W MMP1 hom High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p