YKL046C / DCW1

Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL046C / DCW1

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:2.94|P-value:4.43E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.03|P-value:4.44E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.12|P-value:3.14E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.14|P-value:1.91E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.67|P-value:1.74E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.17|P-value:2.56E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:2.83|P-value:6.83E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.52|P-value:1.81E-7 ID:SGTC_347|Compound:4534-1311|FD-Score:3.20|P-value:1.50E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.22|P-value:1.35E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.65|P-value:3.04E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.66|P-value:2.92E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.80|P-value:9.45E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:3.27|P-value:1.14E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:2.91|P-value:4.94E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.01|P-value:3.33E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.79|P-value:9.96E-6 ID:SGTC_849|Compound:0386-0493|FD-Score:3.08|P-value:2.45E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:-2.91|P-value:7.25E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:2.76|P-value:8.82E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-2.98|P-value:5.50E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.05|P-value:2.88E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:2.90|P-value:5.21E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.08|P-value:2.50E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.75|P-value:9.32E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.84|P-value:6.67E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.08|P-value:2.45E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-2.93|P-value:6.72E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:2.77|P-value:8.59E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:-2.93|P-value:6.69E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.31|P-value:1.08E-6 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.37|P-value:7.22E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.56|P-value:2.98E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.87|P-value:5.92E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.11|P-value:2.16E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.07|P-value:2.62E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.88|P-value:5.59E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.09|P-value:2.36E-4 ID:SGTC_1759|Compound:st043059|FD-Score:-3.26|P-value:1.75E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.43|P-value:8.57E-5 ID:SGTC_2021|Compound:4019055|FD-Score:2.84|P-value:6.65E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.89|P-value:9.73E-6 ID:SGTC_2262|Compound:9014885|FD-Score:2.79|P-value:7.82E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.06|P-value:2.43E-6 ID:SGTC_2324|Compound:6149169|FD-Score:2.88|P-value:5.60E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.09|P-value:2.41E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.24|P-value:1.89E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.82|P-value:7.13E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.27|P-value:1.65E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.63|P-value:9.95E-8 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.90|P-value:1.81E-11 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.24|P-value:1.25E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.59|P-value:2.63E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:2.94|P-value:4.43E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.03|P-value:4.44E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.12|P-value:3.14E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.14|P-value:1.91E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.67|P-value:1.74E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.17|P-value:2.56E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:2.83|P-value:6.83E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.52|P-value:1.81E-7 ID:SGTC_347|Compound:4534-1311|FD-Score:3.20|P-value:1.50E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.22|P-value:1.35E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.65|P-value:3.04E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.66|P-value:2.92E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.80|P-value:9.45E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:3.27|P-value:1.14E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:2.91|P-value:4.94E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.01|P-value:3.33E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.79|P-value:9.96E-6 ID:SGTC_849|Compound:0386-0493|FD-Score:3.08|P-value:2.45E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:-2.91|P-value:7.25E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:2.76|P-value:8.82E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-2.98|P-value:5.50E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.05|P-value:2.88E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:2.90|P-value:5.21E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.08|P-value:2.50E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.75|P-value:9.32E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.84|P-value:6.67E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.08|P-value:2.45E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-2.93|P-value:6.72E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:2.77|P-value:8.59E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:-2.93|P-value:6.69E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.31|P-value:1.08E-6 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.37|P-value:7.22E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.56|P-value:2.98E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.87|P-value:5.92E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.11|P-value:2.16E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.07|P-value:2.62E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.88|P-value:5.59E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.09|P-value:2.36E-4 ID:SGTC_1759|Compound:st043059|FD-Score:-3.26|P-value:1.75E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.43|P-value:8.57E-5 ID:SGTC_2021|Compound:4019055|FD-Score:2.84|P-value:6.65E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.89|P-value:9.73E-6 ID:SGTC_2262|Compound:9014885|FD-Score:2.79|P-value:7.82E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.06|P-value:2.43E-6 ID:SGTC_2324|Compound:6149169|FD-Score:2.88|P-value:5.60E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.09|P-value:2.41E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.24|P-value:1.89E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.82|P-value:7.13E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.27|P-value:1.65E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.63|P-value:9.95E-8 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.90|P-value:1.81E-11 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.24|P-value:1.25E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.59|P-value:2.63E-5

Top fitness defect scores for YKL046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2538 3',7'-epoxycaryophyllan-6-one 5.90 100.0 µM 1.81E-11 3 1.82E-9
2 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 4.63 63.6 µM 9.95E-8 25 1.87E-6
3 SGTC_346 4513-0042 4.52 7.2 µM 1.81E-7 azole & statin 26 3.03E-6
4 SGTC_2318 6029776 4.06 164.0 µM 2.43E-6 30 2.46E-5
5 SGTC_431 k089-0097 3.80 107.0 µM 9.45E-6 iron homeostasis 52 7.35E-5
6 SGTC_732 3970-1727 3.79 52.7 µM 9.96E-6 12 7.67E-5
7 SGTC_130 0136-0219 3.67 337.7 µM 1.74E-5 28 1.20E-4
8 SGTC_3316 9136639 3.59 10.6 µM 2.63E-5 20 1.68E-4
9 SGTC_1525 8-methoxypsoralen 3.56 92.5 µM 2.98E-5 DNA damage response 47 1.86E-4
10 SGTC_1524 corynanthine 3.37 62.1 µM 7.22E-5 38 3.80E-4
11 SGTC_541 4513-1321 3.27 94.0 µM 1.14E-4 43 5.47E-4
12 SGTC_2639 lactacystin 3.24 53.0 µM 1.25E-4 55 5.93E-4
13 SGTC_359 0081-0058 3.22 15.9 µM 1.35E-4 60S ribosome export 85 6.30E-4
14 SGTC_347 4534-1311 3.20 26.2 µM 1.50E-4 RPP1 & pyrimidine depletion 33 6.85E-4
15 SGTC_75 0159-0059 3.14 199.0 µM 1.91E-4 fatty acid desaturase (OLE1) 52 8.34E-4
16 SGTC_1712 st032288 3.11 53.4 µM 2.16E-4 calcium & mitochondrial duress 253 9.20E-4
17 SGTC_1748 st037455 3.09 53.6 µM 2.36E-4 74 9.89E-4
18 SGTC_2329 6138490 3.09 200.0 µM 2.41E-4 79 0.00100
19 SGTC_849 0386-0493 3.08 241.0 µM 2.45E-4 50 0.00102
20 SGTC_1253 0550-0034 3.08 176.0 µM 2.45E-4 58 0.00102

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.46E-16 YAL014C SYN8 hom Endosomal SNARE related to mammalian syntaxin 8
0.124 4.65E-13 YPL121C MEI5 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
0.110 1.81E-10 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.103 2.49E-9 YKL072W STB6 hom Protein that binds Sin3p in a two-hybrid assay
0.101 4.24E-9 YPL049C DIG1 hom MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
0.096 2.26E-8 YOL153C YOL153C hom Hypothetical protein
0.093 5.82E-8 YKL039W PTM1 hom Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication
0.089 2.58E-7 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.089 2.58E-7 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.089 2.67E-7 YGR254W ENO1 hom Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress
0.088 3.31E-7 YJL082W IML2 hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication
0.088 3.54E-7 YOR344C TYE7 hom Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
0.086 5.99E-7 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.083 1.40E-6 YIL064W SEE1 hom Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport
0.083 1.55E-6 YLR309C IMH1 hom Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi