HIPHOP chemogenomics database

YKL047W_p / ANR2

Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain

fixedexpanded
Profile for YKL047W / ANR2

Click on Significant Values for Screen Details

Top fitness defect scores for YKL047W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_387	norethindrone acetate	7.61	66.7 µM	1.58E-14		2	1.37E-14
2	SGTC_2837	9008476	6.17	45.5 µM	3.73E-10		4	3.41E-10
3	SGTC_920	mycophenolic acid	5.44	780.4 nM	2.80E-8		4	2.61E-8
4	SGTC_3137	9097352	5.35	49.5 µM	4.70E-8		14	4.41E-8
5	SGTC_3259	9138485	5.35	49.5 µM	4.72E-8		3	4.43E-8
6	SGTC_1923	st058458	5.22	19.1 µM	9.32E-8		12	8.77E-8
7	SGTC_1868	st057644	5.13	42.7 µM	1.56E-7		16	1.47E-7
8	SGTC_3345	9148410	4.92	3.6 µM	4.47E-7		2	4.24E-7
9	SGTC_286	k060-0067	4.79	22.9 µM	8.69E-7	tubulin folding & SWR complex	14	8.26E-7
10	SGTC_1672	st016598	4.77	6.5 µM	9.79E-7	endomembrane recycling	45	9.31E-7
11	SGTC_2991	9074669	4.19	71.4 µM	1.46E-5	azole & statin	50	1.41E-5
12	SGTC_3009	9080819	4.16	71.4 µM	1.65E-5		13	1.59E-5
13	SGTC_3002	9075603	4.15	71.4 µM	1.69E-5		18	1.63E-5
14	SGTC_1264	0783-0040	4.10	158.0 µM	2.10E-5		22	2.03E-5
15	SGTC_2472	5377652	3.89	49.4 µM	5.24E-5	TRP & mitochondrial translation	59	5.09E-5
16	SGTC_2125	5246583	3.89	200.0 µM	5.28E-5	tubulin folding & SWR complex	44	5.12E-5
17	SGTC_3305	9127027	3.85	53.8 µM	6.04E-5		19	5.86E-5
18	SGTC_1921	5740136	3.79	50.0 µM	7.89E-5	TRP & mitochondrial translation	66	7.67E-5
19	SGTC_2342	7990637	3.78	118.9 µM	8.11E-5	RNA processing & uracil transport	42	7.88E-5
20	SGTC_415	dibenzyl ketone	3.77	100.0 µM	8.35E-5		13	8.11E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.098	1.12E-8	YNL090W	RHO2	hom	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
0.098	1.35E-8	YBR217W	ATG12	hom	Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
0.090	1.70E-7	YDL222C	FMP45	hom	Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.085	7.47E-7	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.085	8.69E-7	YJR137C	MET5	hom	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.084	1.15E-6	YLR043C	TRX1	hom	Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.079	4.72E-6	YDL199C_p	YDL199C_p	hom	Putative transporter, member of the sugar porter family
0.079	4.68E-6	YDL157C_p	YDL157C_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.077	7.24E-6	YDR160W	SSY1	het	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.076	1.01E-5	YKR052C	MRS4	hom	Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication
0.075	1.29E-5	YMR011W	HXT2	hom	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.075	1.35E-5	YJL042W	MHP1	hom	Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.075	1.36E-5	YDL237W	AIM6	hom	Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
0.075	1.42E-5	YER067W	RGI1	hom	Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.075	1.49E-5	YHR045W_p	YHR045W_p	hom	Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum