YKL061W_p / BLI1

Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL061W / BLI1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.75|P-value:3.07E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.81|P-value:2.09E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:4.04|P-value:8.11E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:4.20|P-value:3.59E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:4.34|P-value:1.81E-6 ID:SGTC_738|Compound:1315-0003|FD-Score:4.94|P-value:6.48E-8 ID:SGTC_752|Compound:1896-0090|FD-Score:4.68|P-value:2.91E-7 ID:SGTC_761|Compound:k216-0224|FD-Score:3.18|P-value:3.41E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.56|P-value:7.10E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.14|P-value:4.04E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.64|P-value:5.06E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.41|P-value:1.35E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.74|P-value:3.20E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.65|P-value:4.95E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.26|P-value:2.49E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.24|P-value:3.00E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.04|P-value:5.89E-4 ID:SGTC_1603|Compound:st002045|FD-Score:2.93|P-value:8.82E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.27|P-value:2.18E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.29|P-value:2.06E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.61|P-value:4.13E-7 ID:SGTC_1801|Compound:st050089|FD-Score:2.91|P-value:9.36E-4 ID:SGTC_1817|Compound:st052116|FD-Score:-2.90|P-value:9.07E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.28|P-value:2.14E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.07|P-value:5.31E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.53|P-value:8.35E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-2.96|P-value:7.18E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.71|P-value:3.76E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.36|P-value:1.52E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.20|P-value:7.22E-28 ID:SGTC_2705|Compound:st078069|FD-Score:-3.05|P-value:5.14E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.02|P-value:6.39E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.96|P-value:7.22E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.12|P-value:4.29E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.90|P-value:8.31E-8 ID:SGTC_2833|Compound:9001315|FD-Score:3.65|P-value:4.79E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.11|P-value:4.54E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-4.55|P-value:5.06E-7 ID:SGTC_3222|Compound:9128301|FD-Score:5.19|P-value:1.46E-8 ID:SGTC_3231|Compound:9132313|FD-Score:3.10|P-value:4.74E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.02|P-value:6.41E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.75|P-value:3.07E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.81|P-value:2.09E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:4.04|P-value:8.11E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:4.20|P-value:3.59E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:4.34|P-value:1.81E-6 ID:SGTC_738|Compound:1315-0003|FD-Score:4.94|P-value:6.48E-8 ID:SGTC_752|Compound:1896-0090|FD-Score:4.68|P-value:2.91E-7 ID:SGTC_761|Compound:k216-0224|FD-Score:3.18|P-value:3.41E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.56|P-value:7.10E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.14|P-value:4.04E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.64|P-value:5.06E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.41|P-value:1.35E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.74|P-value:3.20E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.65|P-value:4.95E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.26|P-value:2.49E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.24|P-value:3.00E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.04|P-value:5.89E-4 ID:SGTC_1603|Compound:st002045|FD-Score:2.93|P-value:8.82E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.27|P-value:2.18E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.29|P-value:2.06E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.61|P-value:4.13E-7 ID:SGTC_1801|Compound:st050089|FD-Score:2.91|P-value:9.36E-4 ID:SGTC_1817|Compound:st052116|FD-Score:-2.90|P-value:9.07E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.28|P-value:2.14E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.07|P-value:5.31E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.53|P-value:8.35E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-2.96|P-value:7.18E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.71|P-value:3.76E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.36|P-value:1.52E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.20|P-value:7.22E-28 ID:SGTC_2705|Compound:st078069|FD-Score:-3.05|P-value:5.14E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.02|P-value:6.39E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.96|P-value:7.22E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.12|P-value:4.29E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.90|P-value:8.31E-8 ID:SGTC_2833|Compound:9001315|FD-Score:3.65|P-value:4.79E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.11|P-value:4.54E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-4.55|P-value:5.06E-7 ID:SGTC_3222|Compound:9128301|FD-Score:5.19|P-value:1.46E-8 ID:SGTC_3231|Compound:9132313|FD-Score:3.10|P-value:4.74E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.02|P-value:6.41E-4

Top fitness defect scores for YKL061W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 10.20 96.7 µM 7.22E-28 calcium & mitochondrial duress 23 1.39E-24
2 SGTC_3222 9128301 5.19 49.5 µM 1.46E-8 60S ribosome export 9 1.06E-7
3 SGTC_738 1315-0003 4.94 72.4 µM 6.48E-8 10 3.91E-7
4 SGTC_2824 7998404 4.90 52.0 µM 8.31E-8 16 4.86E-7
5 SGTC_752 1896-0090 4.68 130.0 µM 2.91E-7 TSC3-RPN4 7 1.46E-6
6 SGTC_1762 st045503 4.61 25.5 µM 4.13E-7 15 1.98E-6
7 SGTC_649 1123-0311 4.34 367.0 µM 1.81E-6 endomembrane recycling 57 7.25E-6
8 SGTC_1365 1672-3266 4.24 55.4 µM 3.00E-6 12 1.13E-5
9 SGTC_528 3492-0019 4.20 172.0 µM 3.59E-6 calcium & mitochondrial duress 200 1.32E-5
10 SGTC_308 4092-1169 4.04 104.0 µM 8.11E-6 plasma membrane duress 48 2.72E-5
11 SGTC_6 0844-0013 3.75 19.8 µM 3.07E-5 109 8.75E-5
12 SGTC_1234 0326-0494 3.74 15.5 µM 3.20E-5 20 9.08E-5
13 SGTC_2615 purpurogallin-4-carboxylic acid 3.71 100.0 µM 3.76E-5 redox potentiating 73 1.05E-4
14 SGTC_2833 9001315 3.65 45.5 µM 4.79E-5 amide catabolism 69 1.29E-4
15 SGTC_1257 0669-0121 3.65 16.0 µM 4.95E-5 37 1.33E-4
16 SGTC_1045 1348-1485 3.64 165.0 µM 5.06E-5 44 1.36E-4
17 SGTC_840 0245-0196 3.56 390.0 µM 7.10E-5 21 1.83E-4
18 SGTC_2021 4019055 3.53 173.0 µM 8.35E-5 endomembrane recycling 154 2.11E-4
19 SGTC_1183 1254-0324 3.41 198.0 µM 1.35E-4 41 3.23E-4
20 SGTC_1344 1488-0097 3.26 29.1 µM 2.49E-4 38 5.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 8.38E-44 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.233 2.12E-42 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.230 1.51E-41 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.222 1.25E-38 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.204 8.62E-33 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.200 1.01E-31 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.200 1.63E-31 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.197 1.25E-30 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.193 1.41E-29 YGR237C_p YGR237C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.186 1.44E-27 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.180 7.36E-26 YEL005C VAB2 hom Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter
0.179 1.22E-25 YDL137W ARF2 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication
0.176 1.18E-24 YMR230W-A_p YMR230W-A_p hom Putative protein of unknown function
0.176 1.20E-24 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.174 2.89E-24 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability