HIPHOP chemogenomics database

YKL063C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi

Zygosity: Homozygous strain

fixedexpanded
Profile for YKL063C / YKL063C

Click on Significant Values for Screen Details

Top fitness defect scores for YKL063C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_498	2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)	9.22	150.0 µM	1.21E-25	Golgi	4	1.43E-20
2	SGTC_164	4100-3994	5.82	89.6 µM	2.63E-11		7	2.97E-9
3	SGTC_1229	0139-0193	4.34	12.2 µM	4.95E-7	RSC complex & mRNA processing	4	7.22E-6
4	SGTC_1712	st032288	4.26	53.4 µM	7.59E-7	calcium & mitochondrial duress	168	1.01E-5
5	SGTC_763	3453-1109	4.18	128.0 µM	1.22E-6		11	1.47E-5
6	SGTC_3203	9113543	4.13	49.5 µM	1.56E-6		27	1.80E-5
7	SGTC_2620	irigenin	4.08	100.0 µM	2.12E-6		37	2.29E-5
8	SGTC_169	k015-0017	4.04	16.0 µM	2.59E-6		18	2.68E-5
9	SGTC_394	menadione	4.02	8.3 µM	2.86E-6	superoxide	27	2.91E-5
10	SGTC_3328	9140624	3.97	29.0 µM	3.65E-6		20	3.52E-5
11	SGTC_2639	lactacystin	3.90	53.0 µM	5.43E-6		24	4.84E-5
12	SGTC_838	0109-0203	3.89	71.4 µM	5.61E-6		16	4.96E-5
13	SGTC_2598	perillyl alcohol	3.84	100.0 µM	7.40E-6		35	6.19E-5
14	SGTC_2605	digitonin	3.73	300.0 nM	1.26E-5		38	9.47E-5
15	SGTC_38	0929-0051	3.60	58.3 µM	2.38E-5		28	1.57E-4
16	SGTC_986	1493-0483	3.26	84.0 µM	1.19E-4		33	5.64E-4
17	SGTC_1230	0170-0365	3.25	3.8 µM	1.23E-4	endomembrane recycling	110	5.81E-4
18	SGTC_1735	st034310	3.24	56.8 µM	1.28E-4	Golgi	52	5.99E-4
19	SGTC_1305	1181-0477	3.17	144.0 µM	1.75E-4		42	7.69E-4
20	SGTC_193	1273-0060	3.16	1.6 µM	1.79E-4	ergosterol biosynthesis	25	7.83E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.119	3.85E-12	YGR207C	CIR1	hom	Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.116	1.86E-11	YGL035C	MIG1	hom	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.115	2.38E-11	YGL185C_p	YGL185C_p	hom	Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.113	5.09E-11	YDR525W-A	SNA2	hom	Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.112	8.92E-11	YLR132C	USB1	het	Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.110	1.66E-10	YKL051W	SFK1	hom	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.107	4.27E-10	YPL151C	PRP46	het	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.107	4.32E-10	YMR094W	CTF13	het	Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.107	4.53E-10	YPL119C	DBP1	hom	Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress
0.106	6.23E-10	YOR347C	PYK2	hom	Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication
0.105	1.00E-9	YHR127W	YHR127W	hom	Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis
0.105	1.06E-9	YDL185W	VMA1	hom	Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
0.099	8.22E-9	YBR094W	PBY1	hom	Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress
0.098	1.20E-8	YDR132C	YDR132C	hom	Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.098	1.55E-8	YIR013C	GAT4	hom	Protein containing GATA family zinc finger motifs