YKL063C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL063C / YKL063C

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.60|P-value:2.38E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:2.77|P-value:8.67E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:5.82|P-value:2.63E-11 ID:SGTC_169|Compound:k015-0017|FD-Score:4.04|P-value:2.59E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:3.16|P-value:1.79E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.07|P-value:2.73E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.08|P-value:2.61E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.18|P-value:1.72E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-2.93|P-value:4.77E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.02|P-value:2.86E-6 ID:SGTC_489|Compound:paxilline|FD-Score:2.86|P-value:6.18E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:9.22|P-value:1.21E-25 ID:SGTC_694|Compound:1315-0438|FD-Score:2.75|P-value:9.62E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.12|P-value:2.18E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.78|P-value:8.83E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.18|P-value:1.22E-6 ID:SGTC_838|Compound:0109-0203|FD-Score:3.89|P-value:5.61E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:3.08|P-value:2.50E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.26|P-value:1.19E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.34|P-value:4.95E-7 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.25|P-value:1.23E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.17|P-value:1.75E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.26|P-value:7.59E-7 ID:SGTC_1735|Compound:st034310|FD-Score:3.24|P-value:1.28E-4 ID:SGTC_1910|Compound:st062352|FD-Score:2.94|P-value:4.50E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-2.88|P-value:5.83E-4 ID:SGTC_2021|Compound:4019055|FD-Score:2.76|P-value:9.07E-4 ID:SGTC_2125|Compound:5246583|FD-Score:2.75|P-value:9.40E-4 ID:SGTC_2415|Compound:st077333|FD-Score:2.77|P-value:8.85E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.84|P-value:7.40E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:3.73|P-value:1.26E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:4.08|P-value:2.12E-6 ID:SGTC_2625|Compound:euphol|FD-Score:2.80|P-value:7.94E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.90|P-value:5.43E-6 ID:SGTC_2788|Compound:5282734|FD-Score:-2.89|P-value:5.79E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.18|P-value:1.73E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.13|P-value:1.56E-6 ID:SGTC_3328|Compound:9140624|FD-Score:3.97|P-value:3.65E-6 ID:SGTC_38|Compound:0929-0051|FD-Score:3.60|P-value:2.38E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:2.77|P-value:8.67E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:5.82|P-value:2.63E-11 ID:SGTC_169|Compound:k015-0017|FD-Score:4.04|P-value:2.59E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:3.16|P-value:1.79E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.07|P-value:2.73E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.08|P-value:2.61E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.18|P-value:1.72E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-2.93|P-value:4.77E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.02|P-value:2.86E-6 ID:SGTC_489|Compound:paxilline|FD-Score:2.86|P-value:6.18E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:9.22|P-value:1.21E-25 ID:SGTC_694|Compound:1315-0438|FD-Score:2.75|P-value:9.62E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.12|P-value:2.18E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.78|P-value:8.83E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.18|P-value:1.22E-6 ID:SGTC_838|Compound:0109-0203|FD-Score:3.89|P-value:5.61E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:3.08|P-value:2.50E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.26|P-value:1.19E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.34|P-value:4.95E-7 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.25|P-value:1.23E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.17|P-value:1.75E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.26|P-value:7.59E-7 ID:SGTC_1735|Compound:st034310|FD-Score:3.24|P-value:1.28E-4 ID:SGTC_1910|Compound:st062352|FD-Score:2.94|P-value:4.50E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-2.88|P-value:5.83E-4 ID:SGTC_2021|Compound:4019055|FD-Score:2.76|P-value:9.07E-4 ID:SGTC_2125|Compound:5246583|FD-Score:2.75|P-value:9.40E-4 ID:SGTC_2415|Compound:st077333|FD-Score:2.77|P-value:8.85E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.84|P-value:7.40E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:3.73|P-value:1.26E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:4.08|P-value:2.12E-6 ID:SGTC_2625|Compound:euphol|FD-Score:2.80|P-value:7.94E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.90|P-value:5.43E-6 ID:SGTC_2788|Compound:5282734|FD-Score:-2.89|P-value:5.79E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.18|P-value:1.73E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.13|P-value:1.56E-6 ID:SGTC_3328|Compound:9140624|FD-Score:3.97|P-value:3.65E-6

Top fitness defect scores for YKL063C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 9.22 150.0 µM 1.21E-25 Golgi 4 1.43E-20
2 SGTC_164 4100-3994 5.82 89.6 µM 2.63E-11 7 2.97E-9
3 SGTC_1229 0139-0193 4.34 12.2 µM 4.95E-7 RSC complex & mRNA processing 4 7.22E-6
4 SGTC_1712 st032288 4.26 53.4 µM 7.59E-7 calcium & mitochondrial duress 168 1.01E-5
5 SGTC_763 3453-1109 4.18 128.0 µM 1.22E-6 11 1.47E-5
6 SGTC_3203 9113543 4.13 49.5 µM 1.56E-6 27 1.80E-5
7 SGTC_2620 irigenin 4.08 100.0 µM 2.12E-6 37 2.29E-5
8 SGTC_169 k015-0017 4.04 16.0 µM 2.59E-6 18 2.68E-5
9 SGTC_394 menadione 4.02 8.3 µM 2.86E-6 superoxide 27 2.91E-5
10 SGTC_3328 9140624 3.97 29.0 µM 3.65E-6 20 3.52E-5
11 SGTC_2639 lactacystin 3.90 53.0 µM 5.43E-6 24 4.84E-5
12 SGTC_838 0109-0203 3.89 71.4 µM 5.61E-6 16 4.96E-5
13 SGTC_2598 perillyl alcohol 3.84 100.0 µM 7.40E-6 35 6.19E-5
14 SGTC_2605 digitonin 3.73 300.0 nM 1.26E-5 38 9.47E-5
15 SGTC_38 0929-0051 3.60 58.3 µM 2.38E-5 28 1.57E-4
16 SGTC_986 1493-0483 3.26 84.0 µM 1.19E-4 33 5.64E-4
17 SGTC_1230 0170-0365 3.25 3.8 µM 1.23E-4 endomembrane recycling 110 5.81E-4
18 SGTC_1735 st034310 3.24 56.8 µM 1.28E-4 Golgi 52 5.99E-4
19 SGTC_1305 1181-0477 3.17 144.0 µM 1.75E-4 42 7.69E-4
20 SGTC_193 1273-0060 3.16 1.6 µM 1.79E-4 ergosterol biosynthesis 25 7.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 3.85E-12 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.116 1.86E-11 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.115 2.38E-11 YGL185C_p YGL185C_p hom Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.113 5.09E-11 YDR525W-A SNA2 hom Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.112 8.92E-11 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.110 1.66E-10 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.107 4.27E-10 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.107 4.32E-10 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.107 4.53E-10 YPL119C DBP1 hom Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress
0.106 6.23E-10 YOR347C PYK2 hom Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication
0.105 1.00E-9 YHR127W YHR127W hom Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis
0.105 1.06E-9 YDL185W VMA1 hom Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
0.099 8.22E-9 YBR094W PBY1 hom Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress
0.098 1.20E-8 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.098 1.55E-8 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs