YKL066W_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL066W / YKL066W

Click on Significant Values for Screen Details ID:SGTC_152|Compound:4469-0003|FD-Score:2.75|P-value:5.00E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.07|P-value:1.19E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.05|P-value:1.15E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.17|P-value:1.16E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.80|P-value:5.68E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.79|P-value:6.00E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-2.90|P-value:3.83E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-2.91|P-value:3.60E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:2.61|P-value:8.74E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:2.72|P-value:5.52E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-2.84|P-value:4.80E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.84|P-value:3.75E-6 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.92|P-value:2.38E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-2.96|P-value:2.91E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.89|P-value:3.95E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.26|P-value:7.34E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.06|P-value:1.86E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.32|P-value:5.56E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.35|P-value:3.10E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-2.83|P-value:4.99E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-2.79|P-value:6.13E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.91|P-value:3.68E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-2.68|P-value:9.58E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.44|P-value:1.97E-5 ID:SGTC_2125|Compound:5246583|FD-Score:4.75|P-value:7.70E-9 ID:SGTC_2246|Compound:7293507|FD-Score:2.95|P-value:2.05E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.40|P-value:2.45E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.06|P-value:1.24E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.08|P-value:1.17E-4 ID:SGTC_3157|Compound:9099274|FD-Score:2.77|P-value:4.54E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.59|P-value:9.66E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:2.75|P-value:5.00E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.07|P-value:1.19E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.05|P-value:1.15E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.17|P-value:1.16E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.80|P-value:5.68E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.79|P-value:6.00E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-2.90|P-value:3.83E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-2.91|P-value:3.60E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:2.61|P-value:8.74E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:2.72|P-value:5.52E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-2.84|P-value:4.80E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.84|P-value:3.75E-6 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.92|P-value:2.38E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-2.96|P-value:2.91E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.89|P-value:3.95E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.26|P-value:7.34E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.06|P-value:1.86E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.32|P-value:5.56E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.35|P-value:3.10E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-2.83|P-value:4.99E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-2.79|P-value:6.13E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.91|P-value:3.68E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-2.68|P-value:9.58E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.44|P-value:1.97E-5 ID:SGTC_2125|Compound:5246583|FD-Score:4.75|P-value:7.70E-9 ID:SGTC_2246|Compound:7293507|FD-Score:2.95|P-value:2.05E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.40|P-value:2.45E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.06|P-value:1.24E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.08|P-value:1.17E-4 ID:SGTC_3157|Compound:9099274|FD-Score:2.77|P-value:4.54E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.59|P-value:9.66E-4

Top fitness defect scores for YKL066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2125 5246583 4.75 200.0 µM 7.70E-9 tubulin folding & SWR complex 29 9.95E-7
2 SGTC_2114 5491910 3.44 81.2 µM 1.97E-5 29 2.88E-4
3 SGTC_2815 7968870 3.40 71.4 µM 2.45E-5 47 3.36E-4
4 SGTC_1370 2001-0092 3.35 44.6 µM 3.10E-5 62 4.00E-4
5 SGTC_3004 9076122 3.08 71.4 µM 1.17E-4 48 0.00105
6 SGTC_366 0181-0206 3.07 4.3 µM 1.19E-4 Golgi 88 0.00106
7 SGTC_2891 9063876 3.06 19.5 µM 1.24E-4 25 0.00109
8 SGTC_2246 7293507 2.95 91.6 µM 2.05E-4 80 0.00157
9 SGTC_1031 k035-0009 2.92 16.0 µM 2.38E-4 85 0.00175
10 SGTC_3157 9099274 2.77 49.5 µM 4.54E-4 58 0.00280
11 SGTC_152 4469-0003 2.75 551.2 µM 5.00E-4 75 0.00300
12 SGTC_894 0960-0238 2.72 55.9 µM 5.52E-4 60 0.00323
13 SGTC_886 0866-0150 2.61 153.0 µM 8.74E-4 102 0.00451
14 SGTC_3336 9143619 2.59 71.4 µM 9.66E-4 98 0.00485
15 SGTC_2341 7987486 2.57 176.7 µM 0.00104 111 0.00511
16 SGTC_2968 9090663 2.53 33.4 µM 0.00122 133 0.00574
17 SGTC_39 0986-0283 2.53 58.4 µM 0.00122 calcium & mitochondrial duress 142 0.00576
18 SGTC_899 1083-0020 2.50 478.0 µM 0.00133 114 0.00614
19 SGTC_2309 7664088 2.46 163.9 µM 0.00157 172 0.00692
20 SGTC_2374 9071832 2.45 200.0 µM 0.00165 endomembrane recycling 77 0.00717

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 2.33E-48 YNL078W NIS1 hom Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
0.243 3.89E-46 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.240 4.05E-45 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.206 2.32E-33 YPL121C MEI5 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
0.200 1.06E-31 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.189 2.58E-28 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.188 3.69E-28 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.184 5.77E-27 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.182 2.42E-26 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.178 2.13E-25 YNL162W-A_p YNL162W-A_p hom Putative protein of unknown function; identified by homology
0.167 1.65E-22 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.165 5.59E-22 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.164 1.16E-21 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.161 5.96E-21 YEL026W SNU13 het RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
0.161 9.05E-21 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication