HIPHOP chemogenomics database

YKL070W_p

Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain

fixedexpanded
Profile for YKL070W / YKL070W

Click on Significant Values for Screen Details

Top fitness defect scores for YKL070W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_53	0973-0023	5.02	40.0 µM	5.56E-8	RNA processing & uracil transport	7	2.62E-7
2	SGTC_1676	st018489	4.50	23.4 µM	9.54E-7	60S ribosome export	21	3.46E-6
3	SGTC_1948	st076329	4.26	66.6 µM	3.17E-6		20	1.03E-5
4	SGTC_358	0075-0058	4.20	9.4 µM	4.13E-6		52	1.31E-5
5	SGTC_1954	st077032	4.20	68.9 µM	4.20E-6		15	1.33E-5
6	SGTC_2106	5357045	3.83	167.3 µM	2.40E-5		20	6.46E-5
7	SGTC_1445	4239-0156	3.77	97.7 µM	3.08E-5		32	8.09E-5
8	SGTC_1009	4106-0057	3.77	9.9 µM	3.08E-5		16	8.10E-5
9	SGTC_822	1487-0950	3.69	154.0 µM	4.48E-5		20	1.14E-4
10	SGTC_2248	tofa	3.58	1.1 µM	6.95E-5	sphingolipid biosynthesis & PDR1	49	1.69E-4
11	SGTC_164	4100-3994	3.52	89.6 µM	9.07E-5		46	2.16E-4
12	SGTC_2594	a-mangostin	3.49	100.0 µM	1.05E-4		47	2.46E-4
13	SGTC_50	0929-0078	3.46	56.4 µM	1.16E-4		69	2.69E-4
14	SGTC_726	3448-4391	3.45	34.2 µM	1.20E-4		28	2.78E-4
15	SGTC_3106	9121286	3.35	49.5 µM	1.85E-4		30	4.11E-4
16	SGTC_3124	9127567	3.23	49.5 µM	2.94E-4	DNA damage response	38	6.27E-4
17	SGTC_1578	josamycin	3.14	24.2 µM	4.08E-4		36	8.43E-4
18	SGTC_2740	felodipine	3.13	17.1 µM	4.32E-4		37	8.89E-4
19	SGTC_593	1203-0218	3.10	61.7 µM	4.77E-4		37	9.73E-4
20	SGTC_1945	st075991	3.09	56.6 µM	4.96E-4	60S ribosome export	55	0.00101

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.122	1.40E-12	YMR008C	PLB1	hom	Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.122	1.56E-12	YMR101C	SRT1	hom	Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.114	4.05E-11	YOL071W	EMI5	hom	Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.106	6.82E-10	YER105C	NUP157	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication
0.100	7.27E-9	YMR184W	ADD37	hom	Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.100	7.74E-9	YKR054C	DYN1	hom	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.097	2.06E-8	YLR237W	THI7	hom	Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.096	2.37E-8	YPR195C_d	YPR195C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.096	2.37E-8	YJR058C	APS2	hom	Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.095	3.74E-8	YML120C	NDI1	hom	NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID
0.090	1.66E-7	YCR030C	SYP1	hom	Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.090	1.78E-7	YGL112C	TAF6	het	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.089	2.17E-7	YJR059W	PTK2	hom	Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.087	3.96E-7	YGL091C	NBP35	het	Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
0.087	4.64E-7	YKL086W	SRX1	hom	Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress