YKL083W_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL083W / YKL083W

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.38|P-value:2.25E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.38|P-value:2.30E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.65|P-value:7.45E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:3.13|P-value:5.69E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:6.59|P-value:5.31E-12 ID:SGTC_537|Compound:1334-0398|FD-Score:3.54|P-value:1.21E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.12|P-value:7.92E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.49|P-value:1.48E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.09|P-value:8.88E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.30|P-value:3.12E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.04|P-value:7.85E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.65|P-value:1.08E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.17|P-value:4.95E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:5.20|P-value:3.80E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.12|P-value:6.03E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.80|P-value:4.05E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.02|P-value:8.65E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.00|P-value:9.03E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.53|P-value:1.71E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.75|P-value:7.04E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.48|P-value:1.55E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.15|P-value:7.17E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.17|P-value:6.72E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.85|P-value:4.68E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.06|P-value:9.70E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.34|P-value:2.67E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_2331|Compound:7980721|FD-Score:6.18|P-value:9.12E-11 ID:SGTC_2333|Compound:9017922|FD-Score:-3.20|P-value:6.06E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.68|P-value:6.93E-5 ID:SGTC_2337|Compound:9009472|FD-Score:5.60|P-value:3.80E-9 ID:SGTC_2363|Compound:9053361|FD-Score:3.38|P-value:2.28E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.22|P-value:4.23E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.34|P-value:2.67E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.99|P-value:9.52E-4 ID:SGTC_2808|Compound:7946468|FD-Score:4.21|P-value:6.63E-6 ID:SGTC_2827|Compound:7993847|FD-Score:3.22|P-value:4.15E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-6.95|P-value:7.34E-13 ID:SGTC_2916|Compound:7875993|FD-Score:3.76|P-value:4.87E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.08|P-value:6.80E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.30|P-value:4.23E-6 ID:SGTC_2995|Compound:9067767|FD-Score:3.41|P-value:2.05E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.00|P-value:8.99E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-4.86|P-value:3.98E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-10.50|P-value:6.95E-27 ID:SGTC_3135|Compound:9127742|FD-Score:3.98|P-value:1.92E-5 ID:SGTC_3302|Compound:9125395|FD-Score:-3.07|P-value:9.46E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.82|P-value:3.80E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.38|P-value:2.25E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.38|P-value:2.30E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.65|P-value:7.45E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:3.13|P-value:5.69E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:6.59|P-value:5.31E-12 ID:SGTC_537|Compound:1334-0398|FD-Score:3.54|P-value:1.21E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.12|P-value:7.92E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.49|P-value:1.48E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.09|P-value:8.88E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.30|P-value:3.12E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.04|P-value:7.85E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.65|P-value:1.08E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.17|P-value:4.95E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:5.20|P-value:3.80E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.12|P-value:6.03E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.80|P-value:4.05E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.02|P-value:8.65E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.00|P-value:9.03E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.53|P-value:1.71E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.75|P-value:7.04E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.48|P-value:1.55E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.15|P-value:7.17E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.17|P-value:6.72E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.85|P-value:4.68E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.06|P-value:9.70E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.34|P-value:2.67E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_2331|Compound:7980721|FD-Score:6.18|P-value:9.12E-11 ID:SGTC_2333|Compound:9017922|FD-Score:-3.20|P-value:6.06E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.68|P-value:6.93E-5 ID:SGTC_2337|Compound:9009472|FD-Score:5.60|P-value:3.80E-9 ID:SGTC_2363|Compound:9053361|FD-Score:3.38|P-value:2.28E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.22|P-value:4.23E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.34|P-value:2.67E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.99|P-value:9.52E-4 ID:SGTC_2808|Compound:7946468|FD-Score:4.21|P-value:6.63E-6 ID:SGTC_2827|Compound:7993847|FD-Score:3.22|P-value:4.15E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-6.95|P-value:7.34E-13 ID:SGTC_2916|Compound:7875993|FD-Score:3.76|P-value:4.87E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.08|P-value:6.80E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.30|P-value:4.23E-6 ID:SGTC_2995|Compound:9067767|FD-Score:3.41|P-value:2.05E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.00|P-value:8.99E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-4.86|P-value:3.98E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-10.50|P-value:6.95E-27 ID:SGTC_3135|Compound:9127742|FD-Score:3.98|P-value:1.92E-5 ID:SGTC_3302|Compound:9125395|FD-Score:-3.07|P-value:9.46E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.82|P-value:3.80E-5

Top fitness defect scores for YKL083W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_518 1021-0119 6.59 62.6 µM 5.31E-12 ERG2 1 2.18E-11 0.99
2 SGTC_2331 7980721 6.18 200.0 µM 9.12E-11 3 3.22E-10 0.02
3 SGTC_2337 9009472 5.60 200.0 µM 3.80E-9 3 1.10E-8 0.54
4 SGTC_1254 0550-0035 5.20 264.0 µM 3.80E-8 1 9.72E-8 0.37
5 SGTC_219 mitoxanthrone 4.65 164.4 µM 7.45E-7 DNA intercalators 10 1.62E-6 0.33
6 SGTC_2976 9009005 4.30 19.5 µM 4.23E-6 7 8.39E-6 0.65
7 SGTC_2808 7946468 4.21 45.5 µM 6.63E-6 4 1.28E-5 0.30
8 SGTC_3135 9127742 3.98 49.5 µM 1.92E-5 1 3.50E-5 0.26
9 SGTC_3308 9128332 3.82 17.6 µM 3.80E-5 plasma membrane duress 11 6.69E-5 0.17
10 SGTC_1371 2421-0008 3.80 32.7 µM 4.05E-5 mitochondrial processes 27 7.10E-5 0.02
11 SGTC_2916 7875993 3.76 68.8 µM 4.87E-5 7 8.45E-5 0.15
12 SGTC_2335 9018011 3.68 154.2 µM 6.93E-5 13 1.18E-4 0.01
13 SGTC_2286 7945697 3.56 125.0 µM 1.13E-4 15 1.88E-4 0.15
14 SGTC_537 1334-0398 3.54 209.0 µM 1.21E-4 13 2.00E-4 0.26
15 SGTC_588 3970-1144 3.49 52.9 µM 1.48E-4 1 2.42E-4 0.41
16 SGTC_1712 st032288 3.48 53.4 µM 1.55E-4 calcium & mitochondrial duress 45 2.52E-4 0.08
17 SGTC_2995 9067767 3.41 71.4 µM 2.05E-4 4 3.29E-4 0.00
18 SGTC_15 0266-0086 3.38 27.1 µM 2.25E-4 endomembrane recycling 17 3.58E-4 0.01
19 SGTC_2363 9053361 3.38 176.0 µM 2.28E-4 Golgi 18 3.64E-4 0.20
20 SGTC_142 0335-0849 3.38 62.7 µM 2.30E-4 ubiquinone biosynthesis & proteasome 29 3.67E-4 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 1.44E-35 YGR198W YPP1 het Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
0.151 1.63E-18 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.151 1.70E-18 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.146 1.70E-17 YDR082W STN1 het Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
0.146 2.34E-17 YER018C SPC25 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.144 5.15E-17 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.140 4.94E-16 YMR288W HSH155 het U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
0.131 2.93E-14 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.130 3.43E-14 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.127 1.29E-13 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.127 1.67E-13 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.126 2.12E-13 YKL088W CAB3 het Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC
0.124 5.57E-13 YGL142C GPI10 het Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog
0.121 1.77E-12 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.121 1.93E-12 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein