YKL096C-B_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL096C-B / YKL096C-B

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.56|P-value:4.41E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.44|P-value:6.50E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.03|P-value:7.68E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.52|P-value:5.02E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.49|P-value:1.33E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.61|P-value:3.42E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.84|P-value:1.52E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.75|P-value:2.15E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.73|P-value:2.25E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.60|P-value:3.64E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.43|P-value:6.38E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.50|P-value:5.34E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.33|P-value:8.65E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.11|P-value:8.70E-7 ID:SGTC_784|Compound:4579-0127|FD-Score:4.28|P-value:3.13E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.42|P-value:6.83E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:5.41|P-value:2.06E-7 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.56|P-value:4.33E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.59|P-value:8.24E-8 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.60|P-value:3.82E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.06|P-value:7.41E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.64|P-value:3.11E-4 ID:SGTC_1548|Compound:st061468|FD-Score:-3.50|P-value:5.06E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.85|P-value:1.60E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-4.43|P-value:1.60E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.51|P-value:4.87E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-3.58|P-value:3.83E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-5.35|P-value:2.49E-7 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.51|P-value:5.13E-4 ID:SGTC_2007|Compound:4011539|FD-Score:5.93|P-value:1.42E-8 ID:SGTC_2009|Compound:4012297|FD-Score:5.79|P-value:2.91E-8 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.77|P-value:1.99E-4 ID:SGTC_2289|Compound:7946404|FD-Score:7.49|P-value:1.16E-12 ID:SGTC_2341|Compound:7987486|FD-Score:3.78|P-value:2.06E-4 ID:SGTC_2354|Compound:9060492|FD-Score:5.15|P-value:7.33E-7 ID:SGTC_2399|Compound:5884133|FD-Score:5.33|P-value:3.00E-7 ID:SGTC_2444|Compound:5485484|FD-Score:4.53|P-value:1.12E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.42|P-value:6.95E-4 ID:SGTC_2450|Compound:5739737|FD-Score:6.71|P-value:1.67E-10 ID:SGTC_2453|Compound:5731132|FD-Score:3.48|P-value:5.64E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.59|P-value:3.93E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.40|P-value:7.40E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.55|P-value:4.21E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.77|P-value:1.06E-10 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.82|P-value:1.73E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:7.25|P-value:5.79E-12 ID:SGTC_2772|Compound:vinpocetine|FD-Score:5.93|P-value:1.40E-8 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-6.33|P-value:1.40E-9 ID:SGTC_2931|Compound:9014674|FD-Score:4.20|P-value:4.29E-5 ID:SGTC_3069|Compound:9117009|FD-Score:3.44|P-value:6.48E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.38|P-value:7.45E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.23|P-value:3.71E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.49|P-value:5.23E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.74|P-value:2.34E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:3.56|P-value:4.41E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.44|P-value:6.50E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.03|P-value:7.68E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.52|P-value:5.02E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.49|P-value:1.33E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.61|P-value:3.42E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.84|P-value:1.52E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.75|P-value:2.15E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.73|P-value:2.25E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.60|P-value:3.64E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.43|P-value:6.38E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.50|P-value:5.34E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.33|P-value:8.65E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.11|P-value:8.70E-7 ID:SGTC_784|Compound:4579-0127|FD-Score:4.28|P-value:3.13E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.42|P-value:6.83E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:5.41|P-value:2.06E-7 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.56|P-value:4.33E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.59|P-value:8.24E-8 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.60|P-value:3.82E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.06|P-value:7.41E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.64|P-value:3.11E-4 ID:SGTC_1548|Compound:st061468|FD-Score:-3.50|P-value:5.06E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.85|P-value:1.60E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-4.43|P-value:1.60E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.51|P-value:4.87E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-3.58|P-value:3.83E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-5.35|P-value:2.49E-7 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.51|P-value:5.13E-4 ID:SGTC_2007|Compound:4011539|FD-Score:5.93|P-value:1.42E-8 ID:SGTC_2009|Compound:4012297|FD-Score:5.79|P-value:2.91E-8 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.77|P-value:1.99E-4 ID:SGTC_2289|Compound:7946404|FD-Score:7.49|P-value:1.16E-12 ID:SGTC_2341|Compound:7987486|FD-Score:3.78|P-value:2.06E-4 ID:SGTC_2354|Compound:9060492|FD-Score:5.15|P-value:7.33E-7 ID:SGTC_2399|Compound:5884133|FD-Score:5.33|P-value:3.00E-7 ID:SGTC_2444|Compound:5485484|FD-Score:4.53|P-value:1.12E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.42|P-value:6.95E-4 ID:SGTC_2450|Compound:5739737|FD-Score:6.71|P-value:1.67E-10 ID:SGTC_2453|Compound:5731132|FD-Score:3.48|P-value:5.64E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.59|P-value:3.93E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.40|P-value:7.40E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.55|P-value:4.21E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.77|P-value:1.06E-10 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.82|P-value:1.73E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:7.25|P-value:5.79E-12 ID:SGTC_2772|Compound:vinpocetine|FD-Score:5.93|P-value:1.40E-8 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-6.33|P-value:1.40E-9 ID:SGTC_2931|Compound:9014674|FD-Score:4.20|P-value:4.29E-5 ID:SGTC_3069|Compound:9117009|FD-Score:3.44|P-value:6.48E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.38|P-value:7.45E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.23|P-value:3.71E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.49|P-value:5.23E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.74|P-value:2.34E-4

Top fitness defect scores for YKL096C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2289 7946404 7.49 165.1 µM 1.16E-12 22 3.46E-14
2 SGTC_2771 fluoxetine 7.25 41.0 µM 5.79E-12 2 2.14E-13
3 SGTC_2450 5739737 6.71 12.9 µM 1.67E-10 1 9.79E-12
4 SGTC_2772 vinpocetine 5.93 57.1 µM 1.40E-8 4 1.50E-9
5 SGTC_2007 4011539 5.93 71.8 µM 1.42E-8 cell wall signaling 25 1.52E-9
6 SGTC_2009 4012297 5.79 12.1 µM 2.91E-8 cell wall signaling 24 3.43E-9
7 SGTC_1134 3477-0009 5.59 42.5 µM 8.24E-8 11 1.12E-8
8 SGTC_791 1348-1292 5.41 225.0 µM 2.06E-7 12 3.16E-8
9 SGTC_2399 5884133 5.33 200.0 µM 3.00E-7 cell wall signaling 35 4.85E-8
10 SGTC_2354 9060492 5.15 162.0 µM 7.33E-7 3 1.34E-7
11 SGTC_708 3448-5400 5.11 146.0 µM 8.70E-7 16 1.62E-7
12 SGTC_2444 5485484 4.53 36.4 µM 1.12E-5 19 2.93E-6
13 SGTC_277 nystatin 4.49 15.5 µM 1.33E-5 5 3.58E-6
14 SGTC_784 4579-0127 4.28 173.0 µM 3.13E-5 13 9.42E-6
15 SGTC_3132 9126706 4.23 49.5 µM 3.71E-5 14 1.14E-5
16 SGTC_2931 9014674 4.20 55.7 µM 4.29E-5 17 1.35E-5
17 SGTC_1250 0485-0349 4.06 40.2 µM 7.41E-5 32 2.50E-5
18 SGTC_1560 lithocholic acid 3.85 53.1 µM 1.60E-4 5 5.97E-5
19 SGTC_2688 kanamycin b 3.82 96.7 µM 1.73E-4 calcium & mitochondrial duress 394 6.56E-5
20 SGTC_2341 7987486 3.78 176.7 µM 2.06E-4 20 7.95E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.331 2.42E-86 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.289 1.29E-65 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.259 1.28E-52 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.243 2.41E-46 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.234 4.41E-43 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.232 4.27E-42 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.224 2.02E-39 YOR002W ALG6 hom Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
0.222 8.27E-39 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.217 4.66E-37 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.176 8.89E-25 YJL139C YUR1 hom Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication
0.174 2.39E-24 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.167 1.82E-22 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.136 2.26E-15 YMR238W DFG5 hom Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
0.136 2.91E-15 YDR525W_d API2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology
0.133 9.28E-15 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization