YKL099C / UTP11

Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL099C / UTP11

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.09|P-value:2.84E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.23|P-value:2.06E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.51|P-value:2.78E-7 ID:SGTC_496|Compound:calpeptin|FD-Score:3.75|P-value:1.50E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.20|P-value:2.32E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:2.80|P-value:8.92E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.23|P-value:1.64E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.09|P-value:3.57E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.87|P-value:1.09E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:-2.89|P-value:7.77E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.83|P-value:7.97E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:2.96|P-value:4.79E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:2.89|P-value:6.31E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-2.87|P-value:8.38E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.20|P-value:1.81E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.66|P-value:3.05E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.64|P-value:2.56E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.77|P-value:1.83E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.37|P-value:1.11E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-3.32|P-value:1.38E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.49|P-value:3.13E-7 ID:SGTC_1636|Compound:st007707|FD-Score:3.32|P-value:1.07E-4 ID:SGTC_1671|Compound:st016596|FD-Score:4.36|P-value:6.50E-7 ID:SGTC_1741|Compound:st038134|FD-Score:-3.28|P-value:1.65E-4 ID:SGTC_1801|Compound:st050089|FD-Score:2.81|P-value:8.70E-4 ID:SGTC_2107|Compound:5363541|FD-Score:2.94|P-value:5.25E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-2.96|P-value:6.10E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-2.92|P-value:7.13E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.36|P-value:9.23E-5 ID:SGTC_2295|Compound:7971645|FD-Score:12.60|P-value:9.27E-45 ID:SGTC_2296|Compound:7971656|FD-Score:5.04|P-value:1.07E-8 ID:SGTC_2301|Compound:7769476|FD-Score:-4.06|P-value:4.32E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.30|P-value:1.20E-4 ID:SGTC_2436|Compound:5633522|FD-Score:2.85|P-value:7.38E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.00|P-value:5.15E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.18|P-value:2.02E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.22|P-value:1.68E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-2.87|P-value:8.47E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.09|P-value:2.84E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.23|P-value:2.06E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.51|P-value:2.78E-7 ID:SGTC_496|Compound:calpeptin|FD-Score:3.75|P-value:1.50E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.20|P-value:2.32E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:2.80|P-value:8.92E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.23|P-value:1.64E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.09|P-value:3.57E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.87|P-value:1.09E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:-2.89|P-value:7.77E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.83|P-value:7.97E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:2.96|P-value:4.79E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:2.89|P-value:6.31E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-2.87|P-value:8.38E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.20|P-value:1.81E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.66|P-value:3.05E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.64|P-value:2.56E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.77|P-value:1.83E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.37|P-value:1.11E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-3.32|P-value:1.38E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.49|P-value:3.13E-7 ID:SGTC_1636|Compound:st007707|FD-Score:3.32|P-value:1.07E-4 ID:SGTC_1671|Compound:st016596|FD-Score:4.36|P-value:6.50E-7 ID:SGTC_1741|Compound:st038134|FD-Score:-3.28|P-value:1.65E-4 ID:SGTC_1801|Compound:st050089|FD-Score:2.81|P-value:8.70E-4 ID:SGTC_2107|Compound:5363541|FD-Score:2.94|P-value:5.25E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-2.96|P-value:6.10E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-2.92|P-value:7.13E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.36|P-value:9.23E-5 ID:SGTC_2295|Compound:7971645|FD-Score:12.60|P-value:9.27E-45 ID:SGTC_2296|Compound:7971656|FD-Score:5.04|P-value:1.07E-8 ID:SGTC_2301|Compound:7769476|FD-Score:-4.06|P-value:4.32E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.30|P-value:1.20E-4 ID:SGTC_2436|Compound:5633522|FD-Score:2.85|P-value:7.38E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.00|P-value:5.15E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.18|P-value:2.02E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.22|P-value:1.68E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-2.87|P-value:8.47E-4

Top fitness defect scores for YKL099C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2295 7971645 12.60 200.0 µM 9.27E-45 1 6.25E-37 7.06
2 SGTC_2296 7971656 5.04 126.5 µM 1.07E-8 6 2.28E-7 1.15
3 SGTC_473 2-arachidonoylglycerol 4.51 10.0 µM 2.78E-7 1 3.30E-6 0.34
4 SGTC_1626 st003712 4.49 1.8 µM 3.13E-7 6 3.63E-6 0.09
5 SGTC_1671 st016596 4.36 74.5 µM 6.50E-7 2 6.62E-6 0.90
6 SGTC_496 calpeptin 3.75 138.0 µM 1.50E-5 6 8.74E-5 0.15
7 SGTC_1346 1488-2224 3.64 62.4 µM 2.56E-5 16 1.36E-4 0.15
8 SGTC_2286 7945697 3.36 125.0 µM 9.23E-5 18 3.91E-4 0.00
9 SGTC_1636 st007707 3.32 68.9 µM 1.07E-4 13 4.43E-4 0.12
10 SGTC_2329 6138490 3.30 200.0 µM 1.20E-4 22 4.87E-4 0.02
11 SGTC_608 k048-0125 3.23 159.0 µM 1.64E-4 11 6.27E-4 0.07
12 SGTC_2794 7785382 3.22 27.3 µM 1.68E-4 25 6.39E-4 0.05
13 SGTC_1069 diphenylcyclopropenone 3.20 8.5 µM 1.81E-4 17 6.81E-4 0.01
14 SGTC_2770 toltrazuril 3.18 17.5 µM 2.02E-4 5 7.46E-4 0.03
15 SGTC_18 0111-0177 3.09 500.0 nM 2.84E-4 11 9.87E-4 0.02
16 SGTC_958 1222-0007 2.96 33.0 µM 4.79E-4 19 0.00152 0.03
17 SGTC_2107 5363541 2.94 170.2 µM 5.25E-4 20 0.00164 0.00
18 SGTC_966 1300-0360 2.89 30.2 µM 6.31E-4 heme requiring 41 0.00191 0.06
19 SGTC_2436 5633522 2.85 8.1 µM 7.38E-4 31 0.00217 0.00
20 SGTC_910 3454-3003 2.83 490.0 µM 7.97E-4 18 0.00231 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.191 6.42E-29 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.168 1.06E-22 YKL106W AAT1 hom Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
0.168 1.47E-22 YLR226W BUR2 hom Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II
0.161 4.99E-21 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.158 3.71E-20 YLR220W CCC1 hom Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
0.144 4.50E-17 YJL109C UTP10 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
0.143 7.33E-17 YOR293C-A_p YOR293C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.143 7.42E-17 YPL198W RPL7B hom Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication
0.139 7.56E-16 YAL030W SNC1 hom Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication
0.131 2.87E-14 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.129 5.93E-14 YOR105W_p YOR105W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.127 1.50E-13 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.121 1.95E-12 YCR075C ERS1 hom Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
0.120 2.62E-12 YOL034W SMC5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
0.114 2.95E-11 YLL028W TPO1 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane