YKL102C_d

Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL102C / YKL102C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.73|P-value:5.02E-7 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.54|P-value:1.55E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:3.23|P-value:4.16E-4 ID:SGTC_499|Compound:genistein|FD-Score:4.22|P-value:6.23E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.64|P-value:9.56E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:5.07|P-value:7.88E-8 ID:SGTC_995|Compound:3931-2021|FD-Score:3.02|P-value:8.70E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.73|P-value:5.59E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.42|P-value:1.96E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.06|P-value:7.63E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.69|P-value:6.52E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.60|P-value:1.09E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.09|P-value:7.63E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.00|P-value:9.42E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.00|P-value:9.52E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.23|P-value:4.12E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.48|P-value:1.80E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.00|P-value:9.41E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.21|P-value:4.98E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.29|P-value:3.22E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.42|P-value:2.26E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.09|P-value:6.83E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.04|P-value:8.10E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:2.99|P-value:9.77E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.11|P-value:1.07E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.05|P-value:1.37E-5 ID:SGTC_2902|Compound:5787006|FD-Score:-3.23|P-value:4.58E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.11|P-value:6.43E-4 ID:SGTC_3079|Compound:9117512|FD-Score:3.02|P-value:8.76E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.73|P-value:5.02E-7 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.54|P-value:1.55E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:3.23|P-value:4.16E-4 ID:SGTC_499|Compound:genistein|FD-Score:4.22|P-value:6.23E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.64|P-value:9.56E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:5.07|P-value:7.88E-8 ID:SGTC_995|Compound:3931-2021|FD-Score:3.02|P-value:8.70E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.73|P-value:5.59E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.42|P-value:1.96E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.06|P-value:7.63E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.69|P-value:6.52E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.60|P-value:1.09E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.09|P-value:7.63E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.00|P-value:9.42E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.00|P-value:9.52E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.23|P-value:4.12E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.48|P-value:1.80E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.00|P-value:9.41E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.21|P-value:4.98E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.29|P-value:3.22E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.42|P-value:2.26E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.09|P-value:6.83E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.04|P-value:8.10E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:2.99|P-value:9.77E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.11|P-value:1.07E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.05|P-value:1.37E-5 ID:SGTC_2902|Compound:5787006|FD-Score:-3.23|P-value:4.58E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.11|P-value:6.43E-4 ID:SGTC_3079|Compound:9117512|FD-Score:3.02|P-value:8.76E-4

Top fitness defect scores for YKL102C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_966 1300-0360 5.07 30.2 µM 7.88E-8 heme requiring 7 1.98E-7
2 SGTC_6 0844-0013 4.73 19.8 µM 5.02E-7 50 1.13E-6
3 SGTC_499 genistein 4.22 192.0 µM 6.23E-6 1 1.21E-5
4 SGTC_2596 sinensetin 4.11 100.0 µM 1.07E-5 30 2.01E-5
5 SGTC_2597 laccaic acid a 4.05 100.0 µM 1.37E-5 34 2.53E-5
6 SGTC_1008 4106-0037 3.73 6.0 µM 5.59E-5 PDR1 25 9.51E-5
7 SGTC_1046 2001-0062 3.69 216.0 µM 6.52E-5 26 1.10E-4
8 SGTC_1023 4482-3888 3.42 16.0 µM 1.96E-4 TSC3-RPN4 32 3.09E-4
9 SGTC_2081 5214970 3.29 32.3 µM 3.22E-4 50 4.94E-4
10 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.23 14.9 µM 4.12E-4 35 6.23E-4
11 SGTC_170 4197-0004 3.23 226.0 µM 4.16E-4 38 6.29E-4
12 SGTC_2930 9013230 3.11 14.9 µM 6.43E-4 heme biosynthesis & mitochondrial translocase 81 9.47E-4
13 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.09 3.7 µM 6.83E-4 187 0.00100
14 SGTC_1040 k898-0338 3.06 155.0 µM 7.63E-4 55 0.00111
15 SGTC_2517 totarol 3.04 10.0 µM 8.10E-4 58 0.00118
16 SGTC_995 3931-2021 3.02 34.6 µM 8.70E-4 RPP1 & pyrimidine depletion 59 0.00126
17 SGTC_3079 9117512 3.02 49.5 µM 8.76E-4 10 0.00127
18 SGTC_2007 4011539 3.00 71.8 µM 9.41E-4 cell wall signaling 112 0.00135
19 SGTC_1235 benzylparaben 3.00 21.5 µM 9.42E-4 49 0.00136
20 SGTC_1842 st055362 3.00 61.2 µM 9.52E-4 56 0.00137

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.279 8.93E-61 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.198 4.94E-31 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.179 1.55E-25 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.146 1.74E-17 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.145 2.91E-17 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.137 1.98E-15 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.130 3.50E-14 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.130 4.13E-14 YDR352W YPQ2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
0.123 7.05E-13 YOR113W AZF1 hom Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity
0.118 8.29E-12 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.115 2.37E-11 YDL039C PRM7 hom Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
0.114 3.08E-11 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.110 1.45E-10 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.106 6.56E-10 YLR354C TAL1 hom Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
0.106 7.64E-10 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p