YKL105C / SEG2

Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL105C / SEG2

Click on Significant Values for Screen Details

Top fitness defect scores for YKL105C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2420 aureobasidin a 9.15 50.0 nM 5.10E-24 4 2.97E-20
2 SGTC_3049 9092223 5.33 49.5 µM 2.53E-9 5 4.90E-8
3 SGTC_3186 9110464 5.26 49.5 µM 4.05E-9 RPP1 & pyrimidine depletion 1 7.25E-8
4 SGTC_960 1222-0186 5.22 7.7 µM 5.20E-9 13 8.93E-8
5 SGTC_2690 usnic acid 4.52 100.0 µM 3.67E-7 16 3.11E-6
6 SGTC_2014 4013930 4.51 200.0 µM 3.90E-7 14 3.28E-6
7 SGTC_12 0849-0099 4.33 9.3 µM 1.06E-6 16 7.59E-6
8 SGTC_1506 4226-2149 4.07 212.0 µM 4.22E-6 27 2.40E-5
9 SGTC_1731 st035964 3.88 63.0 µM 1.07E-5 30 5.24E-5
10 SGTC_1319 1306-0155 3.85 43.7 µM 1.23E-5 24 5.88E-5
11 SGTC_1722 st034304 3.70 3.6 µM 2.58E-5 mitochondrial processes 34 1.09E-4
12 SGTC_2437 5741531 3.56 144.2 µM 4.83E-5 55 1.85E-4
13 SGTC_1903 st060211 3.49 78.3 µM 6.65E-5 45 2.42E-4
14 SGTC_3055 9094636 3.41 49.5 µM 9.61E-5 23 3.30E-4
15 SGTC_2659 sanguinarine 3.33 24.2 µM 1.36E-4 45 4.41E-4
16 SGTC_1798 st045719 3.28 61.0 µM 1.62E-4 19 5.10E-4
17 SGTC_387 norethindrone acetate 3.21 66.7 µM 2.25E-4 44 6.73E-4
18 SGTC_3146 9095609 3.12 49.5 µM 3.19E-4 53 9.04E-4
19 SGTC_6 0844-0013 3.06 19.8 µM 4.02E-4 200 0.00110
20 SGTC_785 1270-0111 3.03 65.3 µM 4.52E-4 67 0.00121

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.246 1.88E-47 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.144 5.60E-17 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.116 1.50E-11 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.107 5.85E-10 YFL003C MSH4 hom Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
0.098 1.47E-8 YLR344W RPL26A hom Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication
0.097 1.72E-8 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
0.095 3.05E-8 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.095 4.10E-8 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.093 6.00E-8 YLR345W_p YLR345W_p hom Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
0.091 1.49E-7 YPL229W_p YPL229W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication
0.090 1.71E-7 YLR013W GAT3 hom Protein containing GATA family zinc finger motifs
0.090 2.05E-7 YPL189W GUP2 hom Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog
0.089 2.73E-7 YKL141W SDH3 het Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
0.086 6.45E-7 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.086 7.00E-7 YPR058W YMC1 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication