YKL106C-A_p

Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL106C-A / YKL106C-A

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:2.95|P-value:2.98E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.06|P-value:1.56E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:2.75|P-value:7.05E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.75|P-value:6.30E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-2.74|P-value:6.02E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.46|P-value:2.87E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:2.85|P-value:4.59E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.87|P-value:4.19E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-2.69|P-value:7.58E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:2.75|P-value:7.03E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-4.30|P-value:2.06E-7 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.97|P-value:2.78E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.90|P-value:3.65E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:4.64|P-value:3.09E-8 ID:SGTC_1315|Compound:1237-0019|FD-Score:4.24|P-value:3.86E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.65|P-value:8.86E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:2.73|P-value:7.59E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.53|P-value:6.59E-8 ID:SGTC_2316|Compound:5844804|FD-Score:4.52|P-value:7.04E-8 ID:SGTC_2320|Compound:7373003|FD-Score:-4.38|P-value:1.27E-7 ID:SGTC_2348|Compound:9022543|FD-Score:-2.97|P-value:2.28E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.07|P-value:1.76E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:2.87|P-value:4.14E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.53|P-value:6.27E-8 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.08|P-value:1.41E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.07|P-value:1.51E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.10|P-value:1.56E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.87|P-value:5.06E-9 ID:SGTC_2899|Compound:9053889|FD-Score:4.03|P-value:1.35E-6 ID:SGTC_3140|Compound:9094243|FD-Score:-3.33|P-value:4.32E-5 ID:SGTC_3312|Compound:9133330|FD-Score:2.96|P-value:2.89E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:2.95|P-value:2.98E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.06|P-value:1.56E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:2.75|P-value:7.05E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.75|P-value:6.30E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-2.74|P-value:6.02E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.46|P-value:2.87E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:2.85|P-value:4.59E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.87|P-value:4.19E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-2.69|P-value:7.58E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:2.75|P-value:7.03E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-4.30|P-value:2.06E-7 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.97|P-value:2.78E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.90|P-value:3.65E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:4.64|P-value:3.09E-8 ID:SGTC_1315|Compound:1237-0019|FD-Score:4.24|P-value:3.86E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.65|P-value:8.86E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:2.73|P-value:7.59E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.53|P-value:6.59E-8 ID:SGTC_2316|Compound:5844804|FD-Score:4.52|P-value:7.04E-8 ID:SGTC_2320|Compound:7373003|FD-Score:-4.38|P-value:1.27E-7 ID:SGTC_2348|Compound:9022543|FD-Score:-2.97|P-value:2.28E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.07|P-value:1.76E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:2.87|P-value:4.14E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.53|P-value:6.27E-8 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.08|P-value:1.41E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.07|P-value:1.51E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.10|P-value:1.56E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.87|P-value:5.06E-9 ID:SGTC_2899|Compound:9053889|FD-Score:4.03|P-value:1.35E-6 ID:SGTC_3140|Compound:9094243|FD-Score:-3.33|P-value:4.32E-5 ID:SGTC_3312|Compound:9133330|FD-Score:2.96|P-value:2.89E-4

Top fitness defect scores for YKL106C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1312 1218-2183 4.64 165.0 µM 3.09E-8 3 1.72E-6
2 SGTC_2568 diosmetin 4.53 100.0 µM 6.27E-8 17 2.90E-6
3 SGTC_1741 st038134 4.53 10.2 µM 6.59E-8 19 3.01E-6
4 SGTC_2316 5844804 4.52 197.4 µM 7.04E-8 12 3.16E-6
5 SGTC_1315 1237-0019 4.24 3.7 µM 3.86E-7 8 1.11E-5
6 SGTC_2899 9053889 4.03 58.4 µM 1.35E-6 9 2.83E-5
7 SGTC_488 nitrendipine 3.75 139.0 µM 6.30E-6 56 8.87E-5
8 SGTC_543 3844-1095 3.46 191.0 µM 2.87E-5 ERG2 63 2.75E-4
9 SGTC_2602 kawain 3.10 100.0 µM 1.56E-4 70 9.72E-4
10 SGTC_2355 9061122 3.07 103.1 µM 1.76E-4 36 0.00106
11 SGTC_1309 pyrazolanthrone 2.97 13.4 µM 2.78E-4 59 0.00150
12 SGTC_3312 9133330 2.96 71.4 µM 2.89E-4 31 0.00154
13 SGTC_236 1509-0011 2.95 5.3 µM 2.98E-4 458 0.00158
14 SGTC_1311 1190-0148 2.90 100.0 µM 3.65E-4 azole & statin 79 0.00184
15 SGTC_2503 beta-caryophyllene alcohol 2.87 24.7 µM 4.14E-4 40 0.00202
16 SGTC_1142 3253-1408 2.87 9.8 µM 4.19E-4 49 0.00204
17 SGTC_808 0711-0032 2.85 135.0 µM 4.59E-4 62 0.00218
18 SGTC_1300 1094-0077 2.75 113.0 µM 7.03E-4 54 0.00301
19 SGTC_364 0083-0097 2.75 67.7 µM 7.05E-4 92 0.00301
20 SGTC_1467 k284-1082 2.73 293.0 µM 7.59E-4 80 0.00319

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 2.50E-36 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.177 7.07E-25 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.158 3.63E-20 YGL166W CUP2 hom Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.154 2.69E-19 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.152 7.25E-19 YDR262W_p YDR262W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
0.147 1.36E-17 YGL067W NPY1 hom NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member
0.141 2.15E-16 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.135 4.16E-15 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.130 4.79E-14 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.127 1.87E-13 YHR140W_p YHR140W_p hom Putative integral membrane protein of unknown function
0.123 7.81E-13 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.122 1.52E-12 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.121 2.13E-12 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.119 4.77E-12 YLR352W_p YLR352W_p hom Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
0.117 1.13E-11 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p