HIPHOP chemogenomics database

YKL106C-A_p

Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi

Zygosity: Homozygous strain

fixedexpanded
Profile for YKL106C-A / YKL106C-A

Click on Significant Values for Screen Details

Top fitness defect scores for YKL106C-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1312	1218-2183	4.64	165.0 µM	3.09E-8		3	1.72E-6
2	SGTC_2568	diosmetin	4.53	100.0 µM	6.27E-8		17	2.90E-6
3	SGTC_1741	st038134	4.53	10.2 µM	6.59E-8		19	3.01E-6
4	SGTC_2316	5844804	4.52	197.4 µM	7.04E-8		12	3.16E-6
5	SGTC_1315	1237-0019	4.24	3.7 µM	3.86E-7		8	1.11E-5
6	SGTC_2899	9053889	4.03	58.4 µM	1.35E-6		9	2.83E-5
7	SGTC_488	nitrendipine	3.75	139.0 µM	6.30E-6		56	8.87E-5
8	SGTC_543	3844-1095	3.46	191.0 µM	2.87E-5	ERG2	63	2.75E-4
9	SGTC_2602	kawain	3.10	100.0 µM	1.56E-4		70	9.72E-4
10	SGTC_2355	9061122	3.07	103.1 µM	1.76E-4		36	0.00106
11	SGTC_1309	pyrazolanthrone	2.97	13.4 µM	2.78E-4		59	0.00150
12	SGTC_3312	9133330	2.96	71.4 µM	2.89E-4		31	0.00154
13	SGTC_236	1509-0011	2.95	5.3 µM	2.98E-4		458	0.00158
14	SGTC_1311	1190-0148	2.90	100.0 µM	3.65E-4	azole & statin	79	0.00184
15	SGTC_2503	beta-caryophyllene alcohol	2.87	24.7 µM	4.14E-4		40	0.00202
16	SGTC_1142	3253-1408	2.87	9.8 µM	4.19E-4		49	0.00204
17	SGTC_808	0711-0032	2.85	135.0 µM	4.59E-4		62	0.00218
18	SGTC_1300	1094-0077	2.75	113.0 µM	7.03E-4		54	0.00301
19	SGTC_364	0083-0097	2.75	67.7 µM	7.05E-4		92	0.00301
20	SGTC_1467	k284-1082	2.73	293.0 µM	7.59E-4		80	0.00319

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.215	2.50E-36	YDL086W_p	YDL086W_p	hom	Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.177	7.07E-25	YGL263W	COS12	hom	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.158	3.63E-20	YGL166W	CUP2	hom	Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.154	2.69E-19	YDR387C_p	YDR387C_p	hom	Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.152	7.25E-19	YDR262W_p	YDR262W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
0.147	1.36E-17	YGL067W	NPY1	hom	NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member
0.141	2.15E-16	YPR011C_p	YPR011C_p	hom	Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.135	4.16E-15	YGR295C	COS6	hom	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.130	4.79E-14	YJR152W	DAL5	hom	Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.127	1.87E-13	YHR140W_p	YHR140W_p	hom	Putative integral membrane protein of unknown function
0.123	7.81E-13	YAL060W	BDH1	hom	NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.122	1.52E-12	YOL160W_d	YOL160W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.121	2.13E-12	YBR262C	AIM5	hom	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.119	4.77E-12	YLR352W_p	YLR352W_p	hom	Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
0.117	1.13E-11	YOR202W	HIS3	hom	Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p