YKL107W_p

Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL107W / YKL107W

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-2.87|P-value:8.86E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.37|P-value:9.06E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.59|P-value:4.58E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.18|P-value:2.69E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:2.84|P-value:9.55E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-4.04|P-value:5.33E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:-2.99|P-value:5.70E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.10|P-value:3.45E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:2.89|P-value:7.82E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:2.88|P-value:8.13E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-2.95|P-value:6.57E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.49|P-value:6.74E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.05|P-value:4.20E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-2.89|P-value:8.23E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:2.93|P-value:6.67E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:2.85|P-value:9.05E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.31|P-value:1.21E-6 ID:SGTC_1646|Compound:st011709|FD-Score:4.68|P-value:1.59E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-2.97|P-value:6.00E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-8.07|P-value:6.84E-19 ID:SGTC_1793|Compound:st048256|FD-Score:4.01|P-value:5.69E-6 ID:SGTC_1809|Compound:st050081|FD-Score:2.88|P-value:8.24E-4 ID:SGTC_1886|Compound:st057356|FD-Score:4.18|P-value:2.39E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.57|P-value:4.71E-5 ID:SGTC_1948|Compound:st076329|FD-Score:2.95|P-value:6.28E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-4.22|P-value:2.09E-6 ID:SGTC_2147|Compound:5545932|FD-Score:3.41|P-value:9.42E-5 ID:SGTC_2148|Compound:5546263|FD-Score:3.15|P-value:2.86E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.54|P-value:5.82E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.19|P-value:2.59E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.04|P-value:4.43E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.02|P-value:4.71E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.45|P-value:8.24E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.35|P-value:1.24E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-5.47|P-value:1.27E-9 ID:SGTC_2856|Compound:9022925|FD-Score:3.56|P-value:4.93E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-4.41|P-value:7.65E-7 ID:SGTC_3299|Compound:9121982|FD-Score:3.52|P-value:6.03E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.21|P-value:2.25E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.29|P-value:1.38E-6 ID:SGTC_3321|Compound:9137793|FD-Score:-3.36|P-value:1.26E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.53|P-value:5.91E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-2.87|P-value:8.86E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.37|P-value:9.06E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.59|P-value:4.58E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.18|P-value:2.69E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:2.84|P-value:9.55E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-4.04|P-value:5.33E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:-2.99|P-value:5.70E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.10|P-value:3.45E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:2.89|P-value:7.82E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:2.88|P-value:8.13E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-2.95|P-value:6.57E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.49|P-value:6.74E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.05|P-value:4.20E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-2.89|P-value:8.23E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:2.93|P-value:6.67E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:2.85|P-value:9.05E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.31|P-value:1.21E-6 ID:SGTC_1646|Compound:st011709|FD-Score:4.68|P-value:1.59E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-2.97|P-value:6.00E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-8.07|P-value:6.84E-19 ID:SGTC_1793|Compound:st048256|FD-Score:4.01|P-value:5.69E-6 ID:SGTC_1809|Compound:st050081|FD-Score:2.88|P-value:8.24E-4 ID:SGTC_1886|Compound:st057356|FD-Score:4.18|P-value:2.39E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.57|P-value:4.71E-5 ID:SGTC_1948|Compound:st076329|FD-Score:2.95|P-value:6.28E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-4.22|P-value:2.09E-6 ID:SGTC_2147|Compound:5545932|FD-Score:3.41|P-value:9.42E-5 ID:SGTC_2148|Compound:5546263|FD-Score:3.15|P-value:2.86E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.54|P-value:5.82E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.19|P-value:2.59E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.04|P-value:4.43E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.02|P-value:4.71E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.45|P-value:8.24E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.35|P-value:1.24E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-5.47|P-value:1.27E-9 ID:SGTC_2856|Compound:9022925|FD-Score:3.56|P-value:4.93E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-4.41|P-value:7.65E-7 ID:SGTC_3299|Compound:9121982|FD-Score:3.52|P-value:6.03E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.21|P-value:2.25E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.29|P-value:1.38E-6 ID:SGTC_3321|Compound:9137793|FD-Score:-3.36|P-value:1.26E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.53|P-value:5.91E-5

Top fitness defect scores for YKL107W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1646 st011709 4.68 75.6 µM 1.59E-7 1 1.45E-6
2 SGTC_42 0133-0086 4.37 60.6 µM 9.06E-7 19 6.30E-6
3 SGTC_1611 st001856 4.31 99.4 µM 1.21E-6 12 8.06E-6
4 SGTC_3319 9138450 4.29 16.8 µM 1.38E-6 14 8.99E-6
5 SGTC_1886 st057356 4.18 49.9 µM 2.39E-6 60S ribosome export 15 1.43E-5
6 SGTC_1793 st048256 4.01 72.2 µM 5.69E-6 4 2.97E-5
7 SGTC_1917 st066507 3.57 28.5 µM 4.71E-5 Golgi 55 1.77E-4
8 SGTC_2856 9022925 3.56 19.5 µM 4.93E-5 32 1.84E-4
9 SGTC_3299 9121982 3.52 43.1 µM 6.03E-5 45 2.19E-4
10 SGTC_558 k064-0027 3.49 21.3 µM 6.74E-5 DNA damage response 40 2.40E-4
11 SGTC_2350 9023895 3.45 38.9 µM 8.24E-5 ergosterol biosynthesis 46 2.85E-4
12 SGTC_2147 5545932 3.41 89.7 µM 9.42E-5 ergosterol biosynthesis 26 3.19E-4
13 SGTC_2362 9071156 3.35 126.0 µM 1.24E-4 26 4.04E-4
14 SGTC_3314 9135860 3.21 59.4 µM 2.25E-4 43 6.66E-4
15 SGTC_2148 5546263 3.15 113.6 µM 2.86E-4 45 8.18E-4
16 SGTC_321 4534-3890 3.10 65.3 µM 3.45E-4 RPP1 & pyrimidine depletion 21 9.58E-4
17 SGTC_718 1130-0073 3.05 349.0 µM 4.20E-4 61 0.00113
18 SGTC_2341 7987486 3.04 176.7 µM 4.43E-4 56 0.00118
19 SGTC_2347 9049783 3.02 174.8 µM 4.71E-4 77 0.00125
20 SGTC_1948 st076329 2.95 66.6 µM 6.28E-4 81 0.00159

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 7.91E-10 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.091 1.43E-7 YOL022C TSR4 het Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
0.086 5.95E-7 YDR033W MRH1 hom Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication
0.083 1.68E-6 YPL108W_p YPL108W_p hom Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.078 5.47E-6 YJL057C IKS1 hom Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
0.077 7.01E-6 YHR139C-A_d YHR139C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 7.64E-6 YER134C YER134C hom Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene
0.077 8.06E-6 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.076 1.04E-5 YHR018C ARG4 hom Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
0.074 1.79E-5 YOR321W PMT3 hom Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication
0.071 3.98E-5 YML006C GIS4 hom CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
0.070 4.93E-5 YMR003W AIM34 hom Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss
0.069 7.06E-5 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.068 7.19E-5 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.068 7.23E-5 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity