YKL123W_d

Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL123W / YKL123W

Click on Significant Values for Screen Details ID:SGTC_177|Compound:1327-0068|FD-Score:-4.07|P-value:5.05E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.69|P-value:2.13E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:4.80|P-value:2.37E-6 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.33|P-value:1.79E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.25|P-value:9.42E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.10|P-value:4.52E-5 ID:SGTC_1619|Compound:st003326|FD-Score:3.91|P-value:9.70E-5 ID:SGTC_1627|Compound:st003713|FD-Score:-4.10|P-value:4.50E-5 ID:SGTC_1637|Compound:st007924|FD-Score:4.67|P-value:4.26E-6 ID:SGTC_1763|Compound:st044482|FD-Score:-3.36|P-value:6.70E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.86|P-value:1.14E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.78|P-value:1.52E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.44|P-value:5.06E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.93|P-value:8.99E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.68|P-value:2.21E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.61|P-value:2.80E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.52|P-value:3.90E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.79|P-value:1.52E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.57|P-value:3.24E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.37|P-value:6.54E-4 ID:SGTC_3330|Compound:9141424|FD-Score:6.14|P-value:2.26E-9 ID:SGTC_177|Compound:1327-0068|FD-Score:-4.07|P-value:5.05E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.69|P-value:2.13E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:4.80|P-value:2.37E-6 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.33|P-value:1.79E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.25|P-value:9.42E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.10|P-value:4.52E-5 ID:SGTC_1619|Compound:st003326|FD-Score:3.91|P-value:9.70E-5 ID:SGTC_1627|Compound:st003713|FD-Score:-4.10|P-value:4.50E-5 ID:SGTC_1637|Compound:st007924|FD-Score:4.67|P-value:4.26E-6 ID:SGTC_1763|Compound:st044482|FD-Score:-3.36|P-value:6.70E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.86|P-value:1.14E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.78|P-value:1.52E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.44|P-value:5.06E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.93|P-value:8.99E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.68|P-value:2.21E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.61|P-value:2.80E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.52|P-value:3.90E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.79|P-value:1.52E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.57|P-value:3.24E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.37|P-value:6.54E-4 ID:SGTC_3330|Compound:9141424|FD-Score:6.14|P-value:2.26E-9

Top fitness defect scores for YKL123W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3330 9141424 6.14 71.4 µM 2.26E-9 amide catabolism 4 4.00E-10
2 SGTC_278 4092-0821 4.80 23.9 µM 2.37E-6 plasma membrane duress 26 8.11E-7
3 SGTC_1637 st007924 4.67 17.4 µM 4.26E-6 14 1.54E-6
4 SGTC_1142 3253-1408 4.10 9.8 µM 4.52E-5 7 2.04E-5
5 SGTC_2582 agaric acid 3.93 100.0 µM 8.99E-5 redox potentiating 321 4.32E-5
6 SGTC_1619 st003326 3.91 88.7 µM 9.70E-5 60S ribosome export 21 4.69E-5
7 SGTC_1826 st055655 3.86 41.6 µM 1.14E-4 ERG2 42 5.61E-5
8 SGTC_2784 7567673 3.79 72.7 µM 1.52E-4 iron homeostasis 35 7.65E-5
9 SGTC_2108 5365811 3.78 200.0 µM 1.52E-4 16 7.69E-5
10 SGTC_182 3448-4371 3.69 550.5 µM 2.13E-4 25 1.11E-4
11 SGTC_2611 pyromycin 3.68 23.9 µM 2.21E-4 35 1.16E-4
12 SGTC_2633 5,7-dihydroxyisoflavone 3.64 100.0 µM 2.61E-4 39 1.39E-4
13 SGTC_3281 9140613 3.57 49.5 µM 3.24E-4 RPP1 & pyrimidine depletion 33 1.75E-4
14 SGTC_2712 st079126 3.52 47.7 µM 3.90E-4 30 2.14E-4
15 SGTC_3289 9119912 3.37 71.4 µM 6.54E-4 33 3.77E-4
16 SGTC_588 3970-1144 3.12 52.9 µM 0.00145 63 8.99E-4
17 SGTC_3291 9121177 3.11 71.4 µM 0.00150 42 9.31E-4
18 SGTC_3110 9122132 3.10 49.5 µM 0.00156 redox potentiating 43 9.72E-4
19 SGTC_302 1094-0063 3.08 18.9 µM 0.00164 34 0.00103
20 SGTC_563 tetrahydrosecaminediol 3.05 614.0 µM 0.00179 amide catabolism 45 0.00113

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.28E-15 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.135 4.43E-15 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.130 4.78E-14 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.122 1.41E-12 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.120 3.42E-12 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.115 2.22E-11 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.114 2.96E-11 YOL013C HRD1 hom Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
0.114 4.05E-11 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.111 1.04E-10 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.109 2.10E-10 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.109 2.74E-10 YHR092C HXT4 hom High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication
0.104 1.48E-9 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.104 1.75E-9 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.102 3.31E-9 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.097 1.71E-8 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus