YKL131W_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL131W / YKL131W

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-2.89|P-value:3.50E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-5.16|P-value:6.62E-10 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.07|P-value:1.55E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:2.77|P-value:5.48E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:2.98|P-value:2.20E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.79|P-value:5.33E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.98|P-value:2.40E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.18|P-value:8.84E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.89|P-value:2.29E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.69|P-value:8.14E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.26|P-value:6.50E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.87|P-value:2.82E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:3.88|P-value:2.43E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:5.61|P-value:1.96E-11 ID:SGTC_829|Compound:1635-0120|FD-Score:4.91|P-value:3.65E-9 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.89|P-value:3.46E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-5.02|P-value:1.82E-9 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.34|P-value:4.21E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.69|P-value:7.60E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:2.94|P-value:2.60E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.99|P-value:3.01E-21 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.79|P-value:4.99E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.10|P-value:6.97E-7 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.98|P-value:2.21E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.74|P-value:6.57E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.48|P-value:2.03E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.15|P-value:1.09E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.23|P-value:7.40E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-2.81|P-value:4.83E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.05|P-value:1.71E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.86|P-value:3.93E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-2.93|P-value:2.88E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-2.67|P-value:8.61E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.93|P-value:1.81E-6 ID:SGTC_2114|Compound:5491910|FD-Score:-2.98|P-value:2.33E-4 ID:SGTC_2429|Compound:5902844|FD-Score:2.75|P-value:5.98E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.17|P-value:9.29E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.08|P-value:1.39E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-2.74|P-value:6.52E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.17|P-value:4.47E-7 ID:SGTC_2625|Compound:euphol|FD-Score:3.70|P-value:6.69E-6 ID:SGTC_2704|Compound:st078022|FD-Score:2.65|P-value:9.06E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.42|P-value:2.94E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.19|P-value:9.29E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-2.98|P-value:2.41E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-2.89|P-value:3.50E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-5.16|P-value:6.62E-10 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.07|P-value:1.55E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:2.77|P-value:5.48E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:2.98|P-value:2.20E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.79|P-value:5.33E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.98|P-value:2.40E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.18|P-value:8.84E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.89|P-value:2.29E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.69|P-value:8.14E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.26|P-value:6.50E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.87|P-value:2.82E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:3.88|P-value:2.43E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:5.61|P-value:1.96E-11 ID:SGTC_829|Compound:1635-0120|FD-Score:4.91|P-value:3.65E-9 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.89|P-value:3.46E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-5.02|P-value:1.82E-9 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.34|P-value:4.21E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.69|P-value:7.60E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:2.94|P-value:2.60E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.99|P-value:3.01E-21 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.79|P-value:4.99E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.10|P-value:6.97E-7 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.98|P-value:2.21E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.74|P-value:6.57E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.48|P-value:2.03E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.15|P-value:1.09E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.23|P-value:7.40E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-2.81|P-value:4.83E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.05|P-value:1.71E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.86|P-value:3.93E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-2.93|P-value:2.88E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-2.67|P-value:8.61E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.93|P-value:1.81E-6 ID:SGTC_2114|Compound:5491910|FD-Score:-2.98|P-value:2.33E-4 ID:SGTC_2429|Compound:5902844|FD-Score:2.75|P-value:5.98E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.17|P-value:9.29E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.08|P-value:1.39E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-2.74|P-value:6.52E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.17|P-value:4.47E-7 ID:SGTC_2625|Compound:euphol|FD-Score:3.70|P-value:6.69E-6 ID:SGTC_2704|Compound:st078022|FD-Score:2.65|P-value:9.06E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.42|P-value:2.94E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.19|P-value:9.29E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-2.98|P-value:2.41E-4

Top fitness defect scores for YKL131W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_827 3253-0474 5.61 693.0 µM 1.96E-11 2 9.97E-9
2 SGTC_829 1635-0120 4.91 117.0 µM 3.65E-9 DNA damage response 22 4.50E-7
3 SGTC_2621 lithochol-11-enic acid 4.17 100.0 µM 4.47E-7 19 1.51E-5
4 SGTC_1263 0774-1208 4.10 64.8 µM 6.97E-7 43 2.09E-5
5 SGTC_2103 5378138 3.93 10.0 µM 1.81E-6 16 4.19E-5
6 SGTC_656 4090-1979 3.89 187.0 µM 2.29E-6 19 4.98E-5
7 SGTC_822 1487-0950 3.88 154.0 µM 2.43E-6 13 5.21E-5
8 SGTC_2625 euphol 3.70 100.0 µM 6.69E-6 33 1.09E-4
9 SGTC_1373 2887-0003 3.48 58.5 µM 2.03E-5 Golgi 33 2.47E-4
10 SGTC_1008 4106-0037 3.34 6.0 µM 4.21E-5 PDR1 33 4.23E-4
11 SGTC_650 1328-0195 3.18 38.0 µM 8.84E-5 48 7.29E-4
12 SGTC_2436 5633522 3.17 8.1 µM 9.29E-5 42 7.57E-4
13 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.08 3.7 µM 1.39E-4 190 0.00102
14 SGTC_153 4077-0274 2.98 519.7 µM 2.20E-4 53 0.00143
15 SGTC_1270 0831-1170 2.98 17.3 µM 2.21E-4 48 0.00143
16 SGTC_1101 ebselen 2.94 5.3 µM 2.60E-4 68 0.00162
17 SGTC_1143 3454-2408 2.79 5.1 µM 4.99E-4 60S ribosome export 27 0.00262
18 SGTC_112 phenothiazine 2.77 287.2 µM 5.48E-4 unfolded protein response 60 0.00280
19 SGTC_2429 5902844 2.75 64.4 µM 5.98E-4 119 0.00299
20 SGTC_1010 4112-3296 2.69 15.2 µM 7.60E-4 94 0.00357

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.322 6.21E-82 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.299 3.83E-70 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.264 1.86E-54 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.262 8.22E-54 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.246 1.21E-47 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.241 1.25E-45 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.241 1.23E-45 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.240 5.03E-45 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.231 4.77E-42 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.231 8.41E-42 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.230 1.74E-41 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.227 1.40E-40 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.225 7.97E-40 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.224 2.34E-39 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.221 2.58E-38 YPR010C RPA135 het RNA polymerase I second largest subunit A135