YKL139W / CTK1

Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL139W / CTK1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:4.69|P-value:9.26E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.58|P-value:4.65E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.47|P-value:1.83E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:3.41|P-value:9.33E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.61|P-value:4.98E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:6.29|P-value:4.31E-9 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.92|P-value:1.43E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:7.63|P-value:1.48E-12 ID:SGTC_372|Compound:0155-0182|FD-Score:4.13|P-value:8.24E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:6.62|P-value:6.98E-10 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.50|P-value:7.07E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.30|P-value:6.42E-7 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.50|P-value:7.20E-4 ID:SGTC_469|Compound:w7|FD-Score:3.83|P-value:2.38E-4 ID:SGTC_470|Compound:aa-861|FD-Score:5.15|P-value:1.27E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:6.84|P-value:2.01E-10 ID:SGTC_512|Compound:prima-1|FD-Score:4.54|P-value:1.67E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:7.37|P-value:7.51E-12 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.79|P-value:2.28E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.91|P-value:1.81E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.39|P-value:3.08E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:5.11|P-value:1.51E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:3.48|P-value:7.52E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.46|P-value:8.00E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:4.86|P-value:4.44E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:3.52|P-value:6.64E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.54|P-value:5.19E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.98|P-value:8.51E-11 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.35|P-value:9.56E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:10.10|P-value:7.60E-21 ID:SGTC_954|Compound:1189-0853|FD-Score:5.28|P-value:7.15E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:6.96|P-value:9.57E-11 ID:SGTC_1036|Compound:k216-0215|FD-Score:-7.12|P-value:2.69E-11 ID:SGTC_1123|Compound:mangostin|FD-Score:3.42|P-value:9.21E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.56|P-value:5.79E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.40|P-value:9.79E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.43|P-value:8.78E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:9.64|P-value:5.34E-19 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.88|P-value:2.01E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.17|P-value:6.97E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.14|P-value:8.03E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.14|P-value:7.82E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.50|P-value:7.04E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.53|P-value:6.43E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:5.73|P-value:8.14E-8 ID:SGTC_1854|Compound:st056233|FD-Score:4.83|P-value:5.04E-6 ID:SGTC_2038|Compound:4100038|FD-Score:4.51|P-value:1.92E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-11.20|P-value:2.18E-25 ID:SGTC_2128|Compound:5255449|FD-Score:4.90|P-value:3.75E-6 ID:SGTC_2159|Compound:5658611|FD-Score:-3.83|P-value:2.02E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.20|P-value:1.03E-6 ID:SGTC_2271|Compound:7849410|FD-Score:-3.46|P-value:6.78E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-7.81|P-value:3.00E-13 ID:SGTC_2293|Compound:7624732|FD-Score:-8.65|P-value:8.04E-16 ID:SGTC_2322|Compound:7413319|FD-Score:5.11|P-value:1.52E-6 ID:SGTC_2413|Compound:inermin|FD-Score:5.90|P-value:3.41E-8 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.51|P-value:2.36E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.65|P-value:4.35E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.17|P-value:1.18E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.35|P-value:3.63E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.99|P-value:2.57E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.00|P-value:2.06E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:4.04|P-value:1.14E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.69|P-value:3.81E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.53|P-value:5.53E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:6.85|P-value:1.85E-10 ID:SGTC_2777|Compound:climbazole|FD-Score:5.93|P-value:2.98E-8 ID:SGTC_2814|Compound:7977482|FD-Score:-3.52|P-value:5.71E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.96|P-value:1.26E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.43|P-value:8.85E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.76|P-value:2.99E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.25|P-value:5.21E-5 ID:SGTC_2911|Compound:7942208|FD-Score:4.52|P-value:1.81E-5 ID:SGTC_2925|Compound:9010536|FD-Score:3.77|P-value:2.92E-4 ID:SGTC_2965|Compound:9082772|FD-Score:7.70|P-value:9.17E-13 ID:SGTC_3040|Compound:9091894|FD-Score:4.61|P-value:1.29E-5 ID:SGTC_3062|Compound:9077494|FD-Score:6.23|P-value:6.00E-9 ID:SGTC_3197|Compound:9113331|FD-Score:3.40|P-value:9.87E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:4.69|P-value:9.26E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.58|P-value:4.65E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.47|P-value:1.83E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:3.41|P-value:9.33E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.61|P-value:4.98E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:6.29|P-value:4.31E-9 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.92|P-value:1.43E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:7.63|P-value:1.48E-12 ID:SGTC_372|Compound:0155-0182|FD-Score:4.13|P-value:8.24E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:6.62|P-value:6.98E-10 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.50|P-value:7.07E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.30|P-value:6.42E-7 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.50|P-value:7.20E-4 ID:SGTC_469|Compound:w7|FD-Score:3.83|P-value:2.38E-4 ID:SGTC_470|Compound:aa-861|FD-Score:5.15|P-value:1.27E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:6.84|P-value:2.01E-10 ID:SGTC_512|Compound:prima-1|FD-Score:4.54|P-value:1.67E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:7.37|P-value:7.51E-12 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.79|P-value:2.28E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.91|P-value:1.81E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.39|P-value:3.08E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:5.11|P-value:1.51E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:3.48|P-value:7.52E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.46|P-value:8.00E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:4.86|P-value:4.44E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:3.52|P-value:6.64E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.54|P-value:5.19E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.98|P-value:8.51E-11 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.35|P-value:9.56E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:10.10|P-value:7.60E-21 ID:SGTC_954|Compound:1189-0853|FD-Score:5.28|P-value:7.15E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:6.96|P-value:9.57E-11 ID:SGTC_1036|Compound:k216-0215|FD-Score:-7.12|P-value:2.69E-11 ID:SGTC_1123|Compound:mangostin|FD-Score:3.42|P-value:9.21E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.56|P-value:5.79E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.40|P-value:9.79E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.43|P-value:8.78E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:9.64|P-value:5.34E-19 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.88|P-value:2.01E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.17|P-value:6.97E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.14|P-value:8.03E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.14|P-value:7.82E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.50|P-value:7.04E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.53|P-value:6.43E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:5.73|P-value:8.14E-8 ID:SGTC_1854|Compound:st056233|FD-Score:4.83|P-value:5.04E-6 ID:SGTC_2038|Compound:4100038|FD-Score:4.51|P-value:1.92E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-11.20|P-value:2.18E-25 ID:SGTC_2128|Compound:5255449|FD-Score:4.90|P-value:3.75E-6 ID:SGTC_2159|Compound:5658611|FD-Score:-3.83|P-value:2.02E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.20|P-value:1.03E-6 ID:SGTC_2271|Compound:7849410|FD-Score:-3.46|P-value:6.78E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-7.81|P-value:3.00E-13 ID:SGTC_2293|Compound:7624732|FD-Score:-8.65|P-value:8.04E-16 ID:SGTC_2322|Compound:7413319|FD-Score:5.11|P-value:1.52E-6 ID:SGTC_2413|Compound:inermin|FD-Score:5.90|P-value:3.41E-8 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.51|P-value:2.36E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.65|P-value:4.35E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.17|P-value:1.18E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.35|P-value:3.63E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.99|P-value:2.57E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.00|P-value:2.06E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:4.04|P-value:1.14E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.69|P-value:3.81E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.53|P-value:5.53E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:6.85|P-value:1.85E-10 ID:SGTC_2777|Compound:climbazole|FD-Score:5.93|P-value:2.98E-8 ID:SGTC_2814|Compound:7977482|FD-Score:-3.52|P-value:5.71E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.96|P-value:1.26E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.43|P-value:8.85E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.76|P-value:2.99E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.25|P-value:5.21E-5 ID:SGTC_2911|Compound:7942208|FD-Score:4.52|P-value:1.81E-5 ID:SGTC_2925|Compound:9010536|FD-Score:3.77|P-value:2.92E-4 ID:SGTC_2965|Compound:9082772|FD-Score:7.70|P-value:9.17E-13 ID:SGTC_3040|Compound:9091894|FD-Score:4.61|P-value:1.29E-5 ID:SGTC_3062|Compound:9077494|FD-Score:6.23|P-value:6.00E-9 ID:SGTC_3197|Compound:9113331|FD-Score:3.40|P-value:9.87E-4

Top fitness defect scores for YKL139W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_908 3448-7491 10.10 47.7 µM 7.60E-21 mitochondrial stress 8 1.76E-24
2 SGTC_1240 0356-0016 9.64 42.1 µM 5.34E-19 mitochondrial response to ROS 2 2.74E-22
3 SGTC_2965 9082772 7.70 38.6 µM 9.17E-13 mitochondrial response to ROS 5 6.83E-15
4 SGTC_365 0121-0052 7.63 13.6 µM 1.48E-12 mitochondrial response to ROS 8 1.20E-14
5 SGTC_547 1120-0019 7.37 610.0 nM 7.51E-12 azole & statin 3 8.29E-14
6 SGTC_778 3456-2434 6.98 196.0 µM 8.51E-11 mitochondrial response to ROS 14 1.47E-12
7 SGTC_969 1313-0238 6.96 134.0 µM 9.57E-11 mitochondrial processes 2 1.69E-12
8 SGTC_2739 tacrine 6.85 100.9 µM 1.85E-10 heme requiring 1 3.71E-12
9 SGTC_471 1-acyl-paf 6.84 4.0 µM 2.01E-10 DNA intercalators 3 4.10E-12
10 SGTC_383 2324-0395 6.62 7.4 µM 6.98E-10 azole & statin 11 1.79E-11
11 SGTC_350 k064-0020 6.29 19.8 µM 4.31E-9 heme requiring 6 1.55E-10
12 SGTC_3062 9077494 6.23 49.5 µM 6.00E-9 mitochondrial response to ROS 12 2.29E-10
13 SGTC_2581 avocatin a 6.00 64.0 µM 2.06E-8 sphingolipid biosynthesis & PDR1 17 9.89E-10
14 SGTC_2777 climbazole 5.93 1.5 µM 2.98E-8 iron homeostasis 13 1.53E-9
15 SGTC_2413 inermin 5.90 26.1 µM 3.41E-8 20 1.80E-9
16 SGTC_1520 flindersine 5.73 88.0 µM 8.14E-8 10 5.04E-9
17 SGTC_2418 pentamidine 5.51 31.7 µM 2.36E-7 mitochondrial processes 19 1.78E-8
18 SGTC_467 ro 31-8220 5.30 72.8 µM 6.42E-7 calcium & mitochondrial duress 40 5.82E-8
19 SGTC_954 1189-0853 5.28 2.9 µM 7.15E-7 endomembrane recycling 15 6.61E-8
20 SGTC_2167 5876490 5.20 200.0 µM 1.03E-6 11 1.02E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.343 4.46E-93 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.250 4.32E-49 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.239 7.82E-45 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.232 5.38E-42 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.228 1.05E-40 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.208 4.41E-34 YMR119W ASI1 hom Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication
0.206 1.60E-33 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.200 9.86E-32 YBR078W ECM33 hom GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
0.192 3.78E-29 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.169 8.22E-23 YOR101W RAS1 hom GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress
0.149 3.77E-18 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.147 9.15E-18 YNL317W PFS2 het Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
0.143 6.64E-17 YGL113W SLD3 het Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.141 2.20E-16 YGL023C PIB2 hom Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27
0.140 3.87E-16 YDR362C TFC6 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110