HIPHOP chemogenomics database

YKL152C / GPM1

Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis

Zygosity: Heterozygous strain

fixedexpanded
Profile for YKL152C / GPM1

Click on Significant Values for Screen Details

Top fitness defect scores for YKL152C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2936	9038235	5.42	15.6 µM	4.27E-10		2	2.91E-8	0.20
2	SGTC_899	1083-0020	5.15	478.0 µM	2.95E-9		2	1.33E-7	1.47
3	SGTC_2565	isoliquiritigenin	4.46	100.0 µM	2.26E-7		7	4.08E-6	0.03
4	SGTC_2807	7945238	4.40	52.0 µM	3.30E-7		2	5.50E-6	0.59
5	SGTC_3202	9113761	4.36	49.5 µM	4.00E-7		7	6.39E-6	0.28
6	SGTC_690	glyoxal	4.29	20.3 µM	6.11E-7		24	8.94E-6	0.34
7	SGTC_101	0490-5701	3.77	117.5 µM	1.01E-5		6	8.22E-5	0.46
8	SGTC_390	dec-rvkr-cmk	3.72	16.7 µM	1.27E-5	calcium & mitochondrial duress	10	9.86E-5	0.05
9	SGTC_1743	st037606	3.69	46.4 µM	1.46E-5		10	1.10E-4	0.06
10	SGTC_3033	9090887	3.57	49.5 µM	2.70E-5	fatty acid desaturase (OLE1)	23	1.79E-4	0.00
11	SGTC_90	0870-0863	3.45	4.6 µM	4.74E-5		7	2.80E-4	0.02
12	SGTC_1837	st055472	3.39	66.5 µM	6.15E-5		4	3.44E-4	0.09
13	SGTC_898	1000-0849	3.39	28.3 µM	6.30E-5		6	3.50E-4	0.01
14	SGTC_372	0155-0182	3.24	15.9 µM	1.23E-4	mitochondrial response to ROS	13	5.94E-4	0.05
15	SGTC_99	0109-0120	3.21	622.8 µM	1.39E-4		11	6.55E-4	0.12
16	SGTC_100	0086-0128	3.15	49.6 µM	1.85E-4	copper-dependent oxidative stress	19	8.24E-4	0.01
17	SGTC_1788	fluconazole	3.15	20.0 µM	1.87E-4	azole & statin	17	8.30E-4	9.35E-5
18	SGTC_2877	9040724	3.10	71.4 µM	2.28E-4		6	9.72E-4	0.02
19	SGTC_2409	alverine citrate	3.08	64.0 µM	2.46E-4		23	0.00103	0.17
20	SGTC_1360	1598-0022	3.07	39.8 µM	2.56E-4	ERG2	27	0.00107	0.22

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.187	1.02E-27	YGR190C_d	YGR190C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.182	2.53E-26	YDR235W	PRP42	het	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.171	2.10E-23	YLR195C	NMT1	het	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.165	6.11E-22	YBR155W	CNS1	het	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.159	1.88E-20	YDL153C	SAS10	het	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.157	4.99E-20	YER043C	SAH1	het	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.137	1.68E-15	YJL174W	KRE9	het	Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.135	4.95E-15	YNL163C	RIA1	het	Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.132	1.58E-14	YBL004W	UTP20	het	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.123	7.22E-13	YOL133W	HRT1	het	RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
0.118	6.84E-12	YER147C	SCC4	het	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.115	2.36E-11	YKR068C	BET3	het	Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex
0.111	1.25E-10	YHR019C	DED81	het	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.110	1.47E-10	YOR075W	UFE1	het	t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER
0.110	1.52E-10	YLR259C	HSP60	het	Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated