HIPHOP chemogenomics database
YKL154W / SRP102 
Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YKL154W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.151 | 1.24E-18 | YML064C | TEM1 | het | GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis |
| 0.149 | 4.59E-18 | YPL190C | NAB3 | het | RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing |
| 0.138 | 1.04E-15 | YPL185W_d | YPL185W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C |
| 0.137 | 1.43E-15 | YPL244C | HUT1 | hom | Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 |
| 0.134 | 5.69E-15 | YDL045C | FAD1 | het | Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin |
| 0.121 | 1.63E-12 | YKR002W | PAP1 | het | Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping |
| 0.118 | 8.01E-12 | YML130C | ERO1 | het | Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds |
| 0.117 | 1.19E-11 | YKR022C | NTR2 | het | Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly |
| 0.114 | 3.93E-11 | YMR059W | SEN15 | het | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p |
| 0.112 | 7.65E-11 | YGL009C | LEU1 | hom | Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway |
| 0.102 | 2.86E-9 | YLR062C_d | BUD28_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay |
| 0.100 | 5.74E-9 | YBL044W_p | YBL044W_p | hom | Putative protein of unknown function; YBL044W is not an essential protein |
| 0.097 | 1.94E-8 | YKL090W | CUE2 | hom | Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination |
| 0.095 | 3.28E-8 | YFR002W | NIC96 | het | Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) |
| 0.093 | 6.27E-8 | YPL199C_p | YPL199C_p | hom | Putative protein of unknown function, predicted to be palmitoylated |