YKL163W / PIR3

O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL163W / PIR3

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:3.13|P-value:3.89E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.92|P-value:8.72E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.48|P-value:9.02E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.50|P-value:8.23E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:3.48|P-value:9.29E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:3.04|P-value:5.37E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.03|P-value:5.66E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:2.89|P-value:9.47E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.14|P-value:3.74E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-4.45|P-value:8.90E-7 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.53|P-value:7.70E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.20|P-value:2.89E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.24|P-value:2.47E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.31|P-value:1.89E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.03|P-value:7.36E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.86|P-value:1.73E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.24|P-value:2.54E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.40|P-value:1.28E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.17|P-value:3.34E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:-2.92|P-value:8.71E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-2.93|P-value:8.48E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.21|P-value:2.75E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.03|P-value:5.75E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.02|P-value:5.99E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.50|P-value:8.31E-5 ID:SGTC_1834|Compound:st055981|FD-Score:4.21|P-value:2.94E-6 ID:SGTC_1885|Compound:st057546|FD-Score:3.30|P-value:1.96E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.65|P-value:4.34E-5 ID:SGTC_1957|Compound:st077035|FD-Score:-3.96|P-value:1.08E-5 ID:SGTC_2009|Compound:4012297|FD-Score:4.05|P-value:6.77E-6 ID:SGTC_2068|Compound:5226020|FD-Score:-3.14|P-value:3.80E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.46|P-value:9.91E-5 ID:SGTC_2126|Compound:5251174|FD-Score:2.88|P-value:9.59E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.29|P-value:2.11E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-2.95|P-value:7.83E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.07|P-value:5.99E-6 ID:SGTC_2393|Compound:9031399|FD-Score:3.80|P-value:2.17E-5 ID:SGTC_2401|Compound:5128683|FD-Score:-3.64|P-value:4.78E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.15|P-value:3.60E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.07|P-value:4.83E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.42|P-value:1.21E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.81|P-value:1.17E-7 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:2.96|P-value:7.18E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.02|P-value:7.59E-6 ID:SGTC_2700|Compound:st077718|FD-Score:3.58|P-value:6.04E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.10|P-value:4.29E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.18|P-value:3.22E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.46|P-value:9.96E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.14|P-value:3.72E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.15|P-value:3.63E-4 ID:SGTC_2825|Compound:7998094|FD-Score:2.96|P-value:7.30E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.20|P-value:2.86E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-4.92|P-value:6.42E-8 ID:SGTC_2855|Compound:9016525|FD-Score:-3.53|P-value:7.78E-5 ID:SGTC_2885|Compound:9057732|FD-Score:-3.13|P-value:3.99E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.38|P-value:1.41E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.25|P-value:2.45E-6 ID:SGTC_3027|Compound:9089541|FD-Score:3.56|P-value:6.39E-5 ID:SGTC_3175|Compound:9106517|FD-Score:-3.20|P-value:2.94E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-2.97|P-value:7.20E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.39|P-value:1.32E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.03|P-value:5.64E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.13|P-value:3.89E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.92|P-value:8.72E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.48|P-value:9.02E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.50|P-value:8.23E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:3.48|P-value:9.29E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:3.04|P-value:5.37E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.03|P-value:5.66E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:2.89|P-value:9.47E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.14|P-value:3.74E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-4.45|P-value:8.90E-7 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.53|P-value:7.70E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.20|P-value:2.89E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.24|P-value:2.47E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.31|P-value:1.89E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.03|P-value:7.36E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.86|P-value:1.73E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.24|P-value:2.54E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.40|P-value:1.28E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.17|P-value:3.34E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:-2.92|P-value:8.71E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-2.93|P-value:8.48E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.21|P-value:2.75E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.03|P-value:5.75E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.02|P-value:5.99E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.50|P-value:8.31E-5 ID:SGTC_1834|Compound:st055981|FD-Score:4.21|P-value:2.94E-6 ID:SGTC_1885|Compound:st057546|FD-Score:3.30|P-value:1.96E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.65|P-value:4.34E-5 ID:SGTC_1957|Compound:st077035|FD-Score:-3.96|P-value:1.08E-5 ID:SGTC_2009|Compound:4012297|FD-Score:4.05|P-value:6.77E-6 ID:SGTC_2068|Compound:5226020|FD-Score:-3.14|P-value:3.80E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.46|P-value:9.91E-5 ID:SGTC_2126|Compound:5251174|FD-Score:2.88|P-value:9.59E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.29|P-value:2.11E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-2.95|P-value:7.83E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.07|P-value:5.99E-6 ID:SGTC_2393|Compound:9031399|FD-Score:3.80|P-value:2.17E-5 ID:SGTC_2401|Compound:5128683|FD-Score:-3.64|P-value:4.78E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.15|P-value:3.60E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.07|P-value:4.83E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.42|P-value:1.21E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.81|P-value:1.17E-7 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:2.96|P-value:7.18E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.02|P-value:7.59E-6 ID:SGTC_2700|Compound:st077718|FD-Score:3.58|P-value:6.04E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.10|P-value:4.29E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.18|P-value:3.22E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.46|P-value:9.96E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.14|P-value:3.72E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.15|P-value:3.63E-4 ID:SGTC_2825|Compound:7998094|FD-Score:2.96|P-value:7.30E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.20|P-value:2.86E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-4.92|P-value:6.42E-8 ID:SGTC_2855|Compound:9016525|FD-Score:-3.53|P-value:7.78E-5 ID:SGTC_2885|Compound:9057732|FD-Score:-3.13|P-value:3.99E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.38|P-value:1.41E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.25|P-value:2.45E-6 ID:SGTC_3027|Compound:9089541|FD-Score:3.56|P-value:6.39E-5 ID:SGTC_3175|Compound:9106517|FD-Score:-3.20|P-value:2.94E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-2.97|P-value:7.20E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.39|P-value:1.32E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.03|P-value:5.64E-4

Top fitness defect scores for YKL163W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.81 70.0 µM 1.17E-7 redox potentiating 48 7.53E-7
2 SGTC_3003 9075612 4.25 71.4 µM 2.45E-6 15 1.06E-5
3 SGTC_1834 st055981 4.21 52.8 µM 2.94E-6 RPP1 & pyrimidine depletion 30 1.25E-5
4 SGTC_2363 9053361 4.07 176.0 µM 5.99E-6 Golgi 27 2.32E-5
5 SGTC_2009 4012297 4.05 12.1 µM 6.77E-6 cell wall signaling 56 2.59E-5
6 SGTC_1066 ketoconazole 4.03 628.0 nM 7.36E-6 18 2.78E-5
7 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 4.02 100.0 µM 7.59E-6 35 2.86E-5
8 SGTC_2393 9031399 3.80 185.9 µM 2.17E-5 RNA processing & uracil transport 33 7.15E-5
9 SGTC_1894 3',6'-dihydroxyflavone 3.65 78.7 µM 4.34E-5 16 1.31E-4
10 SGTC_2700 st077718 3.58 96.8 µM 6.04E-5 21 1.75E-4
11 SGTC_3027 9089541 3.56 49.5 µM 6.39E-5 fatty acid desaturase (OLE1) 32 1.83E-4
12 SGTC_349 k015-0014 3.50 24.0 µM 8.23E-5 37 2.29E-4
13 SGTC_1828 st055811 3.50 49.0 µM 8.31E-5 14 2.31E-4
14 SGTC_345 1362-0200 3.48 395.0 µM 9.02E-5 30 2.48E-4
15 SGTC_496 calpeptin 3.48 138.0 µM 9.29E-5 28 2.54E-4
16 SGTC_2084 5306078 3.46 60.6 µM 9.91E-5 33 2.69E-4
17 SGTC_2801 7907800 3.46 81.8 µM 9.96E-5 47 2.70E-4
18 SGTC_1127 asiatic acid 3.40 681.4 nM 1.28E-4 39 3.36E-4
19 SGTC_3202 9113761 3.39 49.5 µM 1.32E-4 71 3.45E-4
20 SGTC_1885 st057546 3.30 99.9 µM 1.96E-4 37 4.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 9.17E-16 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.135 5.13E-15 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.109 2.78E-10 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.108 2.92E-10 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.107 5.80E-10 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.104 1.70E-9 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.101 4.92E-9 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.095 3.63E-8 YLR449W FPR4 hom Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
0.093 7.05E-8 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.093 7.16E-8 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.091 1.39E-7 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.089 2.19E-7 YMR025W CSI1 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome
0.089 2.75E-7 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.087 4.40E-7 YLR266C PDR8 hom Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication
0.087 4.51E-7 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm