YKL167C / MRP49

Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL167C / MRP49

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-3.35|P-value:9.42E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.82|P-value:2.66E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.51|P-value:5.66E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.32|P-value:8.26E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.46|P-value:5.27E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.93|P-value:1.02E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.51|P-value:4.38E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.26|P-value:2.85E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:3.36|P-value:7.24E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.33|P-value:7.97E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.38|P-value:6.72E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.67|P-value:2.52E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.04|P-value:6.57E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.96|P-value:1.18E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.43|P-value:5.80E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.39|P-value:8.15E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.74|P-value:1.98E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.67|P-value:5.03E-6 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.44|P-value:5.61E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.31|P-value:8.61E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.08|P-value:5.57E-5 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.40|P-value:6.34E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.20|P-value:3.56E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.45|P-value:5.37E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.38|P-value:8.57E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.63|P-value:2.94E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.04|P-value:6.54E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.61|P-value:3.09E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.61|P-value:6.51E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.58|P-value:4.37E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-5.29|P-value:4.05E-7 ID:SGTC_2273|Compound:7815444|FD-Score:-7.40|P-value:2.41E-12 ID:SGTC_2347|Compound:9049783|FD-Score:4.05|P-value:6.32E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-4.59|P-value:9.46E-6 ID:SGTC_2443|Compound:5493264|FD-Score:4.80|P-value:2.89E-6 ID:SGTC_2807|Compound:7945238|FD-Score:-4.36|P-value:2.50E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.87|P-value:2.11E-6 ID:SGTC_2929|Compound:9013348|FD-Score:-3.35|P-value:9.38E-4 ID:SGTC_3004|Compound:9076122|FD-Score:4.14|P-value:4.44E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-3.38|P-value:8.38E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-4.59|P-value:9.47E-6 ID:SGTC_3309|Compound:9129340|FD-Score:3.43|P-value:5.78E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.35|P-value:9.42E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.82|P-value:2.66E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.51|P-value:5.66E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.32|P-value:8.26E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.46|P-value:5.27E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.93|P-value:1.02E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.51|P-value:4.38E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.26|P-value:2.85E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:3.36|P-value:7.24E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.33|P-value:7.97E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.38|P-value:6.72E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.67|P-value:2.52E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.04|P-value:6.57E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.96|P-value:1.18E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.43|P-value:5.80E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.39|P-value:8.15E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.74|P-value:1.98E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.67|P-value:5.03E-6 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.44|P-value:5.61E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.31|P-value:8.61E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.08|P-value:5.57E-5 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.40|P-value:6.34E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.20|P-value:3.56E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.45|P-value:5.37E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.38|P-value:8.57E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.63|P-value:2.94E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.04|P-value:6.54E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.61|P-value:3.09E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.61|P-value:6.51E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.58|P-value:4.37E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-5.29|P-value:4.05E-7 ID:SGTC_2273|Compound:7815444|FD-Score:-7.40|P-value:2.41E-12 ID:SGTC_2347|Compound:9049783|FD-Score:4.05|P-value:6.32E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-4.59|P-value:9.46E-6 ID:SGTC_2443|Compound:5493264|FD-Score:4.80|P-value:2.89E-6 ID:SGTC_2807|Compound:7945238|FD-Score:-4.36|P-value:2.50E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.87|P-value:2.11E-6 ID:SGTC_2929|Compound:9013348|FD-Score:-3.35|P-value:9.38E-4 ID:SGTC_3004|Compound:9076122|FD-Score:4.14|P-value:4.44E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-3.38|P-value:8.38E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-4.59|P-value:9.47E-6 ID:SGTC_3309|Compound:9129340|FD-Score:3.43|P-value:5.78E-4

Top fitness defect scores for YKL167C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2809 7964133 4.87 13.0 µM 2.11E-6 60S ribosome export 16 5.61E-7
2 SGTC_117 lucigenin 4.82 22.1 µM 2.66E-6 redox potentiating 63 7.28E-7
3 SGTC_2443 5493264 4.80 126.7 µM 2.89E-6 10 7.97E-7
4 SGTC_1266 0828-0227 4.67 32.9 µM 5.03E-6 12 1.49E-6
5 SGTC_2012 4023501 4.61 200.0 µM 6.51E-6 19 1.98E-6
6 SGTC_612 0302-0167 4.26 22.4 µM 2.85E-5 copper-dependent oxidative stress 29 1.04E-5
7 SGTC_1495 4469-0029 4.20 237.0 µM 3.56E-5 97 1.33E-5
8 SGTC_3004 9076122 4.14 71.4 µM 4.44E-5 13 1.71E-5
9 SGTC_1489 4065-0444 4.08 182.0 µM 5.57E-5 17 2.21E-5
10 SGTC_2347 9049783 4.05 174.8 µM 6.32E-5 28 2.54E-5
11 SGTC_1765 st044815 4.04 90.4 µM 6.54E-5 23 2.64E-5
12 SGTC_886 0866-0150 4.04 153.0 µM 6.57E-5 21 2.65E-5
13 SGTC_258 haloperidol 3.93 50.8 µM 1.02E-4 fatty acid desaturase (OLE1) 30 4.33E-5
14 SGTC_1106 tegaserod maleate 3.74 11.7 µM 1.98E-4 28 9.11E-5
15 SGTC_833 3852-0053 3.67 558.0 µM 2.52E-4 20 1.19E-4
16 SGTC_1717 st033143 3.63 58.0 µM 2.94E-4 58 1.42E-4
17 SGTC_2010 4012422 3.61 159.0 µM 3.09E-4 31 1.50E-4
18 SGTC_397 arbidol 3.51 50.0 µM 4.38E-4 cell wall 32 2.22E-4
19 SGTC_245 methotrexate 3.46 289.6 µM 5.27E-4 56 2.73E-4
20 SGTC_1496 4469-0713 3.45 57.4 µM 5.37E-4 31 2.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.51E-8 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.094 4.42E-8 YLR002C NOC3 het Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing
0.090 1.94E-7 YGR172C YIP1 het Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4
0.089 2.58E-7 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.088 3.01E-7 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.088 3.47E-7 YGR084C MRP13 hom Mitochondrial ribosomal protein of the small subunit
0.086 6.49E-7 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.085 8.60E-7 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.085 9.03E-7 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.084 1.15E-6 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.084 1.21E-6 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.083 1.55E-6 YOL027C MDM38 hom Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
0.083 1.65E-6 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.082 1.79E-6 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.082 2.25E-6 YOR140W SFL1 hom Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p