YKL179C / COY1

Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL179C / COY1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:2.30|P-value:8.22E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.34|P-value:6.99E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:2.48|P-value:3.57E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-2.50|P-value:6.47E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:2.31|P-value:7.89E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.66|P-value:3.09E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.00|P-value:2.27E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:-2.89|P-value:9.78E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:-2.74|P-value:2.11E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.56|P-value:1.97E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:2.37|P-value:5.95E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:2.55|P-value:2.58E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:2.27|P-value:9.68E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.45|P-value:3.34E-9 ID:SGTC_1182|Compound:1222-0449|FD-Score:-2.88|P-value:1.02E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.76|P-value:8.65E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.49|P-value:3.01E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.50|P-value:6.43E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-2.61|P-value:3.85E-4 ID:SGTC_1739|Compound:st037196|FD-Score:2.64|P-value:1.62E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.22|P-value:6.49E-6 ID:SGTC_1947|Compound:st076332|FD-Score:-2.63|P-value:3.63E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.01|P-value:5.12E-5 ID:SGTC_2337|Compound:9009472|FD-Score:2.77|P-value:8.25E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-2.92|P-value:8.00E-5 ID:SGTC_2534|Compound:helenine|FD-Score:-3.17|P-value:2.09E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.94|P-value:7.20E-5 ID:SGTC_2537|Compound:larixol|FD-Score:-2.73|P-value:2.19E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.27|P-value:9.37E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.32|P-value:7.48E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.45|P-value:8.39E-4 ID:SGTC_2800|Compound:7887935|FD-Score:2.46|P-value:3.96E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.36|P-value:2.63E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-2.42|P-value:9.33E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-3.09|P-value:3.31E-5 ID:SGTC_2946|Compound:9065502|FD-Score:3.26|P-value:5.16E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-3.27|P-value:1.18E-5 ID:SGTC_2983|Compound:9022671|FD-Score:2.45|P-value:4.20E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.58|P-value:6.59E-7 ID:SGTC_3067|Compound:9117431|FD-Score:2.96|P-value:2.96E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-2.45|P-value:8.23E-4 ID:SGTC_3098|Compound:9119039|FD-Score:2.68|P-value:1.31E-4 ID:SGTC_3219|Compound:9131112|FD-Score:2.35|P-value:6.46E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.70|P-value:2.50E-4 ID:SGTC_3287|Compound:9117173|FD-Score:2.54|P-value:2.62E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.23|P-value:6.16E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-2.86|P-value:1.11E-4 ID:SGTC_3313|Compound:9133968|FD-Score:2.33|P-value:7.25E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:2.30|P-value:8.22E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.34|P-value:6.99E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:2.48|P-value:3.57E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-2.50|P-value:6.47E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:2.31|P-value:7.89E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.66|P-value:3.09E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.00|P-value:2.27E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:-2.89|P-value:9.78E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:-2.74|P-value:2.11E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.56|P-value:1.97E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:2.37|P-value:5.95E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:2.55|P-value:2.58E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:2.27|P-value:9.68E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.45|P-value:3.34E-9 ID:SGTC_1182|Compound:1222-0449|FD-Score:-2.88|P-value:1.02E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.76|P-value:8.65E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.49|P-value:3.01E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.50|P-value:6.43E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-2.61|P-value:3.85E-4 ID:SGTC_1739|Compound:st037196|FD-Score:2.64|P-value:1.62E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.22|P-value:6.49E-6 ID:SGTC_1947|Compound:st076332|FD-Score:-2.63|P-value:3.63E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.01|P-value:5.12E-5 ID:SGTC_2337|Compound:9009472|FD-Score:2.77|P-value:8.25E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-2.92|P-value:8.00E-5 ID:SGTC_2534|Compound:helenine|FD-Score:-3.17|P-value:2.09E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.94|P-value:7.20E-5 ID:SGTC_2537|Compound:larixol|FD-Score:-2.73|P-value:2.19E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.27|P-value:9.37E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.32|P-value:7.48E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.45|P-value:8.39E-4 ID:SGTC_2800|Compound:7887935|FD-Score:2.46|P-value:3.96E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.36|P-value:2.63E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-2.42|P-value:9.33E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-3.09|P-value:3.31E-5 ID:SGTC_2946|Compound:9065502|FD-Score:3.26|P-value:5.16E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-3.27|P-value:1.18E-5 ID:SGTC_2983|Compound:9022671|FD-Score:2.45|P-value:4.20E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.58|P-value:6.59E-7 ID:SGTC_3067|Compound:9117431|FD-Score:2.96|P-value:2.96E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-2.45|P-value:8.23E-4 ID:SGTC_3098|Compound:9119039|FD-Score:2.68|P-value:1.31E-4 ID:SGTC_3219|Compound:9131112|FD-Score:2.35|P-value:6.46E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.70|P-value:2.50E-4 ID:SGTC_3287|Compound:9117173|FD-Score:2.54|P-value:2.62E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.23|P-value:6.16E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-2.86|P-value:1.11E-4 ID:SGTC_3313|Compound:9133968|FD-Score:2.33|P-value:7.25E-4

Top fitness defect scores for YKL179C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2986 9022445 3.58 71.4 µM 6.59E-7 25 1.74E-4
2 SGTC_2919 7978188 3.36 46.4 µM 2.63E-6 47 3.84E-4
3 SGTC_2946 9065502 3.26 71.4 µM 5.16E-6 18 5.67E-4
4 SGTC_3293 9120939 3.23 62.0 µM 6.16E-6 44 6.27E-4
5 SGTC_1829 berberine 3.22 14.4 µM 6.49E-6 60S ribosome export 39 6.47E-4
6 SGTC_634 1611-4317 3.00 11.2 µM 2.27E-5 ERG2 54 0.00133
7 SGTC_3067 9117431 2.96 49.5 µM 2.96E-5 52 0.00155
8 SGTC_2337 9009472 2.77 200.0 µM 8.25E-5 104 0.00281
9 SGTC_1270 0831-1170 2.76 17.3 µM 8.65E-5 71 0.00288
10 SGTC_3098 9119039 2.68 49.5 µM 1.31E-4 Golgi 105 0.00366
11 SGTC_1739 st037196 2.64 92.5 µM 1.62E-4 103 0.00415
12 SGTC_788 1182-0090 2.55 188.0 µM 2.58E-4 endomembrane recycling 207 0.00543
13 SGTC_3287 9117173 2.54 37.1 µM 2.62E-4 60S ribosome export 42 0.00549
14 SGTC_112 phenothiazine 2.48 287.2 µM 3.57E-4 unfolded protein response 91 0.00656
15 SGTC_2800 7887935 2.46 81.8 µM 3.96E-4 RPP1 & pyrimidine depletion 137 0.00697
16 SGTC_2983 9022671 2.45 13.0 µM 4.20E-4 60S ribosome export 104 0.00722
17 SGTC_780 0109-0199 2.37 192.0 µM 5.95E-4 152 0.00883
18 SGTC_3219 9131112 2.35 49.5 µM 6.46E-4 Golgi 142 0.00927
19 SGTC_65 0798-0905 2.34 35.0 µM 6.99E-4 calcium & mitochondrial duress 276 0.00970
20 SGTC_3313 9133968 2.33 57.0 µM 7.25E-4 122 0.00991

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.338 2.23E-90 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.292 3.83E-67 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.288 4.34E-65 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.285 1.13E-63 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.274 6.14E-59 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.270 5.95E-57 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.265 5.89E-55 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.262 1.05E-53 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.261 2.04E-53 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.258 3.06E-52 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.249 8.95E-49 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.249 1.61E-48 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.244 8.37E-47 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.242 9.10E-46 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.237 4.56E-44 YLR267W_p BOP2_p hom Protein of unknown function