YKL187C / FAT3

Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL187C / FAT3

Click on Significant Values for Screen Details

Top fitness defect scores for YKL187C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 8.23 35.0 µM 2.15E-19 calcium & mitochondrial duress 14 9.70E-17
2 SGTC_3323 9138564 6.37 53.9 µM 2.25E-12 1 9.49E-11
3 SGTC_761 k216-0224 4.99 480.0 µM 2.87E-8 7 3.04E-7
4 SGTC_41 0478-0632 4.80 82.6 µM 8.58E-8 13 7.74E-7
5 SGTC_73 0327-0325 4.33 16.2 µM 1.20E-6 DNA damage response 36 7.37E-6
6 SGTC_185 k048-0037 3.74 25.5 µM 2.32E-5 RSC & ERG11 15 9.30E-5
7 SGTC_3142 9086498 3.66 49.5 µM 3.25E-5 iron homeostasis 46 1.24E-4
8 SGTC_654 1124-0271 3.59 80.9 µM 4.46E-5 37 1.63E-4
9 SGTC_2430 5571206 3.51 200.0 µM 6.49E-5 73 2.24E-4
10 SGTC_659 k018-0002 3.42 107.0 µM 9.68E-5 31 3.16E-4
11 SGTC_2991 9074669 3.41 71.4 µM 1.01E-4 azole & statin 92 3.27E-4
12 SGTC_788 1182-0090 3.32 188.0 µM 1.44E-4 endomembrane recycling 115 4.43E-4
13 SGTC_71 0417-1750 3.28 47.8 µM 1.71E-4 Golgi 78 5.12E-4
14 SGTC_3207 9114163 3.21 49.5 µM 2.34E-4 67 6.72E-4
15 SGTC_14 0354-0009 3.18 295.0 µM 2.61E-4 55 7.38E-4
16 SGTC_2871 9038510 3.15 13.0 µM 2.99E-4 47 8.30E-4
17 SGTC_3059 1327-0034 3.01 3.0 µM 5.16E-4 92 0.00132
18 SGTC_1620 st003704 2.99 16.5 µM 5.39E-4 44 0.00137
19 SGTC_2650 prasterone 2.99 100.0 µM 5.48E-4 27 0.00139
20 SGTC_2439 5492030 2.89 7.2 µM 8.05E-4 58 0.00194

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 1.04E-30 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.177 5.22E-25 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.177 7.38E-25 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.172 1.29E-23 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.164 1.41E-21 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.158 3.06E-20 YJR099W YUH1 hom Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
0.154 2.62E-19 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.149 3.81E-18 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.139 6.36E-16 YBR261C TAE1 hom AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm
0.137 1.50E-15 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.135 4.75E-15 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.131 2.72E-14 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.129 6.53E-14 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.128 1.06E-13 YPL067C_p YPL067C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
0.121 1.71E-12 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex