YKL188C / PXA2

Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL188C / PXA2

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.02|P-value:7.25E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:2.95|P-value:9.46E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.02|P-value:7.45E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.60|P-value:7.59E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.15|P-value:4.60E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.46|P-value:1.35E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-2.95|P-value:9.81E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.16|P-value:4.33E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.74|P-value:4.08E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-5.15|P-value:3.26E-8 ID:SGTC_982|Compound:1491-0518|FD-Score:3.71|P-value:4.74E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:4.25|P-value:3.88E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:3.68|P-value:5.27E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.09|P-value:5.94E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:-3.50|P-value:1.20E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.22|P-value:3.59E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.02|P-value:7.41E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.30|P-value:2.51E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.46|P-value:1.44E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.00|P-value:8.23E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.28|P-value:2.90E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.35|P-value:2.09E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.95|P-value:9.77E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.33|P-value:2.30E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.85|P-value:2.72E-5 ID:SGTC_2106|Compound:5357045|FD-Score:3.92|P-value:1.85E-5 ID:SGTC_2117|Compound:5521686|FD-Score:5.71|P-value:9.60E-10 ID:SGTC_2122|Compound:5258151|FD-Score:-4.51|P-value:1.11E-6 ID:SGTC_2391|Compound:6285546|FD-Score:-3.95|P-value:1.66E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.36|P-value:2.01E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-5.06|P-value:5.38E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:-2.95|P-value:9.90E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.83|P-value:2.77E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.04|P-value:7.16E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.03|P-value:6.99E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.20|P-value:3.70E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.02|P-value:7.38E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.02|P-value:7.46E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.02|P-value:7.25E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:2.95|P-value:9.46E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.02|P-value:7.45E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.60|P-value:7.59E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.15|P-value:4.60E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.46|P-value:1.35E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-2.95|P-value:9.81E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.16|P-value:4.33E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.74|P-value:4.08E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-5.15|P-value:3.26E-8 ID:SGTC_982|Compound:1491-0518|FD-Score:3.71|P-value:4.74E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:4.25|P-value:3.88E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:3.68|P-value:5.27E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.09|P-value:5.94E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:-3.50|P-value:1.20E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.22|P-value:3.59E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.02|P-value:7.41E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.30|P-value:2.51E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.46|P-value:1.44E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.00|P-value:8.23E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.28|P-value:2.90E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.35|P-value:2.09E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.95|P-value:9.77E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.33|P-value:2.30E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.85|P-value:2.72E-5 ID:SGTC_2106|Compound:5357045|FD-Score:3.92|P-value:1.85E-5 ID:SGTC_2117|Compound:5521686|FD-Score:5.71|P-value:9.60E-10 ID:SGTC_2122|Compound:5258151|FD-Score:-4.51|P-value:1.11E-6 ID:SGTC_2391|Compound:6285546|FD-Score:-3.95|P-value:1.66E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.36|P-value:2.01E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-5.06|P-value:5.38E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:-2.95|P-value:9.90E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.83|P-value:2.77E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.04|P-value:7.16E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.03|P-value:6.99E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.20|P-value:3.70E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.02|P-value:7.38E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.02|P-value:7.46E-4

Top fitness defect scores for YKL188C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2117 5521686 5.71 200.0 µM 9.60E-10 2 5.78E-9
2 SGTC_983 1491-0821 4.25 12.2 µM 3.88E-6 12 1.08E-5
3 SGTC_2106 5357045 3.92 167.3 µM 1.85E-5 19 4.46E-5
4 SGTC_2801 7907800 3.83 81.8 µM 2.77E-5 29 6.42E-5
5 SGTC_811 0416-0114 3.74 265.0 µM 4.08E-5 32 9.13E-5
6 SGTC_982 1491-0518 3.71 27.5 µM 4.74E-5 19 1.05E-4
7 SGTC_985 1493-0307 3.68 8.7 µM 5.27E-5 TSC3-RPN4 23 1.15E-4
8 SGTC_542 3381-0244 3.60 89.3 µM 7.59E-5 55 1.61E-4
9 SGTC_630 4356-0227 3.46 183.0 µM 1.35E-4 19 2.71E-4
10 SGTC_2438 5259590 3.36 200.0 µM 2.01E-4 28 3.89E-4
11 SGTC_1285 0929-0069 3.35 65.5 µM 2.09E-4 40 4.03E-4
12 SGTC_1742 st038235 3.33 28.9 µM 2.30E-4 mitochondrial stress 150 4.40E-4
13 SGTC_1092 toremifene 3.30 6.3 µM 2.51E-4 42 4.76E-4
14 SGTC_2973 9094665 3.20 18.0 µM 3.70E-4 NEO1 63 6.77E-4
15 SGTC_662 k832-1615 3.16 104.0 µM 4.33E-4 52 7.81E-4
16 SGTC_626 0214-0009 3.15 33.0 µM 4.60E-4 copper-dependent oxidative stress 53 8.26E-4
17 SGTC_2949 9072542 3.03 2.2 µM 6.99E-4 TSC3-RPN4 90 0.00121
18 SGTC_37 0566-0070 3.02 1.6 µM 7.25E-4 82 0.00125
19 SGTC_3085 9117376 3.02 49.5 µM 7.38E-4 47 0.00127
20 SGTC_1080 nisoldipine 3.02 24.4 µM 7.41E-4 TSC3-RPN4 63 0.00127

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.92E-11 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.107 4.44E-10 YIL054W_p YIL054W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.102 3.29E-9 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.097 1.68E-8 YDR160W SSY1 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.086 6.00E-7 YGR249W MGA1 hom Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
0.086 6.57E-7 YGL061C DUO1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.082 2.04E-6 YDR179C CSN9 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
0.078 6.92E-6 YJL201W ECM25 hom Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
0.076 1.00E-5 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.072 3.17E-5 YPL164C MLH3 hom Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
0.071 3.58E-5 YMR207C HFA1 hom Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.070 5.35E-5 YER037W PHM8 hom Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p
0.070 5.38E-5 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.068 7.84E-5 YMR141C_d YMR141C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.067 1.06E-4 YOL039W RPP2A hom Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm