HIPHOP chemogenomics database
YKL188C / PXA2 
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YKL188C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.116 | 1.92E-11 | YAR008W | SEN34 | het | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease |
| 0.107 | 4.44E-10 | YIL054W_p | YIL054W_p | hom | Protein of unknown function; expressed at both mRNA and protein levels |
| 0.102 | 3.29E-9 | YCR011C | ADP1 | hom | Putative ATP-dependent permease of the ABC transporter family of proteins |
| 0.097 | 1.68E-8 | YDR160W | SSY1 | het | Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes |
| 0.086 | 6.00E-7 | YGR249W | MGA1 | hom | Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants |
| 0.086 | 6.57E-7 | YGL061C | DUO1 | het | Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis |
| 0.082 | 2.04E-6 | YDR179C | CSN9 | hom | Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling |
| 0.078 | 6.92E-6 | YJL201W | ECM25 | hom | Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p |
| 0.076 | 1.00E-5 | YMR148W | OSW5 | hom | Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion |
| 0.072 | 3.17E-5 | YPL164C | MLH3 | hom | Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability |
| 0.071 | 3.58E-5 | YMR207C | HFA1 | hom | Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress |
| 0.070 | 5.35E-5 | YER037W | PHM8 | hom | Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p |
| 0.070 | 5.38E-5 | YGL015C_p | YGL015C_p | hom | Putative protein of unknown function; null mutants accumulate cargo in the Golgi |
| 0.068 | 7.84E-5 | YMR141C_d | YMR141C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.067 | 1.06E-4 | YOL039W | RPP2A | hom | Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm |