YKL190W / CNB1

Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL190W / CNB1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.46|P-value:3.76E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.62|P-value:2.14E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.00|P-value:5.70E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.39|P-value:5.15E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:8.46|P-value:9.77E-17 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.58|P-value:4.53E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:5.16|P-value:2.56E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:-6.01|P-value:2.79E-9 ID:SGTC_119|Compound:0121-0043|FD-Score:4.02|P-value:4.53E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:4.89|P-value:9.72E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:3.18|P-value:9.67E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.15|P-value:2.86E-19 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.38|P-value:5.45E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.59|P-value:4.46E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.61|P-value:2.40E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.25|P-value:7.62E-4 ID:SGTC_252|Compound:miconazole|FD-Score:7.24|P-value:9.48E-13 ID:SGTC_255|Compound:tunicamycin|FD-Score:12.70|P-value:3.69E-35 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.03|P-value:4.39E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:6.18|P-value:9.39E-10 ID:SGTC_293|Compound:4049-0273|FD-Score:3.19|P-value:9.50E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.80|P-value:1.52E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:5.38|P-value:8.13E-8 ID:SGTC_312|Compound:4092-0653|FD-Score:4.84|P-value:1.25E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:6.25|P-value:5.89E-10 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.02|P-value:4.47E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.67|P-value:1.73E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.99|P-value:4.60E-15 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.13|P-value:2.95E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:5.54|P-value:3.46E-8 ID:SGTC_548|Compound:1436-0017|FD-Score:5.12|P-value:3.10E-7 ID:SGTC_549|Compound:1661-1316|FD-Score:4.24|P-value:1.83E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:15.50|P-value:2.32E-51 ID:SGTC_582|Compound:0987-0078|FD-Score:8.11|P-value:1.62E-15 ID:SGTC_637|Compound:1181-0519|FD-Score:12.30|P-value:3.81E-33 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.86|P-value:8.58E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:4.40|P-value:9.23E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:9.84|P-value:5.84E-22 ID:SGTC_794|Compound:k038-0031|FD-Score:3.46|P-value:3.81E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.58|P-value:2.48E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.58|P-value:2.47E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.11|P-value:3.21E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:4.96|P-value:7.05E-7 ID:SGTC_896|Compound:0964-0007|FD-Score:3.78|P-value:1.15E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:6.08|P-value:1.71E-9 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.52|P-value:5.99E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:14.30|P-value:3.51E-44 ID:SGTC_959|Compound:1222-0044|FD-Score:3.90|P-value:7.17E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:3.51|P-value:3.19E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:8.52|P-value:5.89E-17 ID:SGTC_1072|Compound:oxiconazole|FD-Score:10.80|P-value:4.18E-26 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.69|P-value:1.80E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.79|P-value:1.11E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.27|P-value:7.18E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.29|P-value:7.25E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.37|P-value:1.05E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.51|P-value:3.36E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.43|P-value:4.15E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.24|P-value:8.70E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.25|P-value:1.72E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.36|P-value:5.37E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.22|P-value:8.56E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.92|P-value:6.76E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.61|P-value:2.34E-4 ID:SGTC_1750|Compound:st081859|FD-Score:20.00|P-value:1.86E-84 ID:SGTC_1754|Compound:st042065|FD-Score:4.14|P-value:2.82E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.36|P-value:1.12E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:7.45|P-value:2.23E-13 ID:SGTC_1818|Compound:st052136|FD-Score:4.19|P-value:2.26E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-8.69|P-value:1.73E-17 ID:SGTC_1859|Compound:st055998|FD-Score:4.03|P-value:4.36E-5 ID:SGTC_1909|Compound:st060837|FD-Score:4.05|P-value:4.02E-5 ID:SGTC_1938|Compound:st074717|FD-Score:6.30|P-value:4.40E-10 ID:SGTC_1941|Compound:st076221|FD-Score:8.54|P-value:4.92E-17 ID:SGTC_2057|Compound:5236571|FD-Score:3.35|P-value:5.56E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.52|P-value:3.35E-4 ID:SGTC_2070|Compound:5230947|FD-Score:-3.62|P-value:2.27E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.31|P-value:6.23E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.42|P-value:4.39E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.40|P-value:4.98E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.04|P-value:4.15E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.97|P-value:5.55E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.47|P-value:3.88E-4 ID:SGTC_2457|Compound:5731572|FD-Score:6.15|P-value:1.11E-9 ID:SGTC_2467|Compound:5474540|FD-Score:-3.41|P-value:4.86E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.57|P-value:2.49E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.97|P-value:5.47E-5 ID:SGTC_2482|Compound:5981709|FD-Score:8.64|P-value:2.21E-17 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.50|P-value:3.30E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.90|P-value:7.41E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:19.50|P-value:2.53E-80 ID:SGTC_2585|Compound:alliin|FD-Score:-3.39|P-value:5.25E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.68|P-value:1.83E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.39|P-value:2.63E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:-8.35|P-value:2.93E-16 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.30|P-value:1.41E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:7.36|P-value:4.20E-13 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.30|P-value:1.24E-7 ID:SGTC_2777|Compound:climbazole|FD-Score:3.68|P-value:1.68E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:10.20|P-value:2.41E-23 ID:SGTC_2820|Compound:7989630|FD-Score:4.14|P-value:2.74E-5 ID:SGTC_2876|Compound:9059903|FD-Score:3.86|P-value:8.56E-5 ID:SGTC_3018|Compound:9082602|FD-Score:8.01|P-value:3.34E-15 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.59|P-value:3.96E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:6.01|P-value:2.51E-9 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.69|P-value:1.60E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.20|P-value:9.03E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.26|P-value:8.05E-4 ID:SGTC_3152|Compound:9099253|FD-Score:8.27|P-value:4.59E-16 ID:SGTC_3257|Compound:9139206|FD-Score:3.26|P-value:7.56E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.42|P-value:4.37E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:3.46|P-value:3.76E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.62|P-value:2.14E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.00|P-value:5.70E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.39|P-value:5.15E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:8.46|P-value:9.77E-17 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.58|P-value:4.53E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:5.16|P-value:2.56E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:-6.01|P-value:2.79E-9 ID:SGTC_119|Compound:0121-0043|FD-Score:4.02|P-value:4.53E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:4.89|P-value:9.72E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:3.18|P-value:9.67E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.15|P-value:2.86E-19 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.38|P-value:5.45E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.59|P-value:4.46E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.61|P-value:2.40E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.25|P-value:7.62E-4 ID:SGTC_252|Compound:miconazole|FD-Score:7.24|P-value:9.48E-13 ID:SGTC_255|Compound:tunicamycin|FD-Score:12.70|P-value:3.69E-35 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.03|P-value:4.39E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:6.18|P-value:9.39E-10 ID:SGTC_293|Compound:4049-0273|FD-Score:3.19|P-value:9.50E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.80|P-value:1.52E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:5.38|P-value:8.13E-8 ID:SGTC_312|Compound:4092-0653|FD-Score:4.84|P-value:1.25E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:6.25|P-value:5.89E-10 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.02|P-value:4.47E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.67|P-value:1.73E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.99|P-value:4.60E-15 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.13|P-value:2.95E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:5.54|P-value:3.46E-8 ID:SGTC_548|Compound:1436-0017|FD-Score:5.12|P-value:3.10E-7 ID:SGTC_549|Compound:1661-1316|FD-Score:4.24|P-value:1.83E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:15.50|P-value:2.32E-51 ID:SGTC_582|Compound:0987-0078|FD-Score:8.11|P-value:1.62E-15 ID:SGTC_637|Compound:1181-0519|FD-Score:12.30|P-value:3.81E-33 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.86|P-value:8.58E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:4.40|P-value:9.23E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:9.84|P-value:5.84E-22 ID:SGTC_794|Compound:k038-0031|FD-Score:3.46|P-value:3.81E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.58|P-value:2.48E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.58|P-value:2.47E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.11|P-value:3.21E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:4.96|P-value:7.05E-7 ID:SGTC_896|Compound:0964-0007|FD-Score:3.78|P-value:1.15E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:6.08|P-value:1.71E-9 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.52|P-value:5.99E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:14.30|P-value:3.51E-44 ID:SGTC_959|Compound:1222-0044|FD-Score:3.90|P-value:7.17E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:3.51|P-value:3.19E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:8.52|P-value:5.89E-17 ID:SGTC_1072|Compound:oxiconazole|FD-Score:10.80|P-value:4.18E-26 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.69|P-value:1.80E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.79|P-value:1.11E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.27|P-value:7.18E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.29|P-value:7.25E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.37|P-value:1.05E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.51|P-value:3.36E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.43|P-value:4.15E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.24|P-value:8.70E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.25|P-value:1.72E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.36|P-value:5.37E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.22|P-value:8.56E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.92|P-value:6.76E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.61|P-value:2.34E-4 ID:SGTC_1750|Compound:st081859|FD-Score:20.00|P-value:1.86E-84 ID:SGTC_1754|Compound:st042065|FD-Score:4.14|P-value:2.82E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.36|P-value:1.12E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:7.45|P-value:2.23E-13 ID:SGTC_1818|Compound:st052136|FD-Score:4.19|P-value:2.26E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-8.69|P-value:1.73E-17 ID:SGTC_1859|Compound:st055998|FD-Score:4.03|P-value:4.36E-5 ID:SGTC_1909|Compound:st060837|FD-Score:4.05|P-value:4.02E-5 ID:SGTC_1938|Compound:st074717|FD-Score:6.30|P-value:4.40E-10 ID:SGTC_1941|Compound:st076221|FD-Score:8.54|P-value:4.92E-17 ID:SGTC_2057|Compound:5236571|FD-Score:3.35|P-value:5.56E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.52|P-value:3.35E-4 ID:SGTC_2070|Compound:5230947|FD-Score:-3.62|P-value:2.27E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.31|P-value:6.23E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.42|P-value:4.39E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.40|P-value:4.98E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.04|P-value:4.15E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.97|P-value:5.55E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.47|P-value:3.88E-4 ID:SGTC_2457|Compound:5731572|FD-Score:6.15|P-value:1.11E-9 ID:SGTC_2467|Compound:5474540|FD-Score:-3.41|P-value:4.86E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.57|P-value:2.49E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.97|P-value:5.47E-5 ID:SGTC_2482|Compound:5981709|FD-Score:8.64|P-value:2.21E-17 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.50|P-value:3.30E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.90|P-value:7.41E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:19.50|P-value:2.53E-80 ID:SGTC_2585|Compound:alliin|FD-Score:-3.39|P-value:5.25E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.68|P-value:1.83E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.39|P-value:2.63E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:-8.35|P-value:2.93E-16 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.30|P-value:1.41E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:7.36|P-value:4.20E-13 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.30|P-value:1.24E-7 ID:SGTC_2777|Compound:climbazole|FD-Score:3.68|P-value:1.68E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:10.20|P-value:2.41E-23 ID:SGTC_2820|Compound:7989630|FD-Score:4.14|P-value:2.74E-5 ID:SGTC_2876|Compound:9059903|FD-Score:3.86|P-value:8.56E-5 ID:SGTC_3018|Compound:9082602|FD-Score:8.01|P-value:3.34E-15 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.59|P-value:3.96E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:6.01|P-value:2.51E-9 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.69|P-value:1.60E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.20|P-value:9.03E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.26|P-value:8.05E-4 ID:SGTC_3152|Compound:9099253|FD-Score:8.27|P-value:4.59E-16 ID:SGTC_3257|Compound:9139206|FD-Score:3.26|P-value:7.56E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.42|P-value:4.37E-4

Top fitness defect scores for YKL190W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 20.00 2.4 µM 1.86E-84 endomembrane recycling 16 2.32E-89
2 SGTC_2582 agaric acid 19.50 100.0 µM 2.53E-80 redox potentiating 2 5.59E-85
3 SGTC_568 1193-0097 15.50 7.5 µM 2.32E-51 ERAD & cell cycle 1 2.79E-54
4 SGTC_955 1216-0110 14.30 33.0 µM 3.51E-44 sphingolipid biosynthesis & PDR1 7 1.13E-46
5 SGTC_255 tunicamycin 12.70 200.5 nM 3.69E-35 unfolded protein response 6 4.11E-37
6 SGTC_637 1181-0519 12.30 7.3 µM 3.81E-33 fatty acid desaturase (OLE1) 12 5.59E-35
7 SGTC_1072 oxiconazole 10.80 14.9 nM 4.18E-26 ergosterol depletion effects on membrane 5 1.60E-27
8 SGTC_2778 tioconazole 10.20 65.1 nM 2.41E-23 ergosterol depletion effects on membrane 14 1.35E-24
9 SGTC_689 0833-0039 9.84 98.0 µM 5.84E-22 ergosterol depletion effects on membrane 3 3.93E-23
10 SGTC_138 0850-0259 9.15 40.9 µM 2.86E-19 cell wall 53 2.78E-20
11 SGTC_2482 5981709 8.64 142.7 µM 2.21E-17 PDR1 2 2.77E-18
12 SGTC_1941 st076221 8.54 61.8 µM 4.92E-17 sphingolipid biosynthesis & PDR1 19 6.46E-18
13 SGTC_964 1287-0107 8.52 19.4 µM 5.89E-17 cell wall 6 7.83E-18
14 SGTC_70 0141-0289 8.46 43.3 µM 9.77E-17 mitochondrial stress 34 1.34E-17
15 SGTC_3152 9099253 8.27 49.5 µM 4.59E-16 NEO1-PIK1 32 6.87E-17
16 SGTC_582 0987-0078 8.11 156.0 µM 1.62E-15 calcium & mitochondrial duress 13 2.60E-16
17 SGTC_3018 9082602 8.01 49.5 µM 3.34E-15 18 5.61E-16
18 SGTC_1789 tunicamycin 7.45 25.0 nM 2.23E-13 unfolded protein response 10 4.78E-14
19 SGTC_2736 butenafine 7.36 14.7 µM 4.20E-13 4 9.36E-14
20 SGTC_252 miconazole 7.24 1.3 nM 9.48E-13 ergosterol depletion effects on membrane 10 2.22E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.341 6.74E-92 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.306 1.12E-73 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.301 1.93E-71 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.294 1.08E-67 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.290 6.65E-66 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.281 9.45E-62 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.273 2.08E-58 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.255 6.13E-51 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.254 2.28E-50 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.252 1.48E-49 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.246 1.87E-47 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.244 1.11E-46 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.242 7.71E-46 YPR153W YPR153W hom Putative protein of unknown function
0.240 3.33E-45 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.239 6.44E-45 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1