YKL205W / LOS1

Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL205W / LOS1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.76|P-value:8.66E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:3.12|P-value:9.48E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.38|P-value:3.05E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-5.05|P-value:1.60E-7 ID:SGTC_360|Compound:0957-0399|FD-Score:3.60|P-value:1.63E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.20|P-value:5.85E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.63|P-value:1.40E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.83|P-value:5.21E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.17|P-value:8.06E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:6.66|P-value:1.31E-11 ID:SGTC_1737|Compound:st035557|FD-Score:-3.39|P-value:2.93E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.54|P-value:1.66E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.78|P-value:6.36E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-5.07|P-value:1.47E-7 ID:SGTC_1805|Compound:st050013|FD-Score:-5.70|P-value:4.09E-9 ID:SGTC_1819|Compound:st053448|FD-Score:4.04|P-value:2.78E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.59|P-value:1.67E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.11|P-value:9.63E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.35|P-value:7.08E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.96|P-value:3.02E-5 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.17|P-value:6.46E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.72|P-value:8.16E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.89|P-value:5.27E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.31|P-value:4.85E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.64|P-value:1.12E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.43|P-value:2.48E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-3.09|P-value:8.61E-4 ID:SGTC_2879|Compound:9041815|FD-Score:-3.35|P-value:3.39E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.29|P-value:5.13E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.76|P-value:8.66E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:3.12|P-value:9.48E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.38|P-value:3.05E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-5.05|P-value:1.60E-7 ID:SGTC_360|Compound:0957-0399|FD-Score:3.60|P-value:1.63E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.20|P-value:5.85E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.63|P-value:1.40E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.83|P-value:5.21E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.17|P-value:8.06E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:6.66|P-value:1.31E-11 ID:SGTC_1737|Compound:st035557|FD-Score:-3.39|P-value:2.93E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.54|P-value:1.66E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.78|P-value:6.36E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-5.07|P-value:1.47E-7 ID:SGTC_1805|Compound:st050013|FD-Score:-5.70|P-value:4.09E-9 ID:SGTC_1819|Compound:st053448|FD-Score:4.04|P-value:2.78E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.59|P-value:1.67E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.11|P-value:9.63E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.35|P-value:7.08E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.96|P-value:3.02E-5 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.17|P-value:6.46E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.72|P-value:8.16E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.89|P-value:5.27E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.31|P-value:4.85E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.64|P-value:1.12E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.43|P-value:2.48E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-3.09|P-value:8.61E-4 ID:SGTC_2879|Compound:9041815|FD-Score:-3.35|P-value:3.39E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.29|P-value:5.13E-4

Top fitness defect scores for YKL205W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1262 0737-0114 6.66 49.6 µM 1.31E-11 4 1.38E-11
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.35 3.7 µM 7.08E-6 60 6.91E-6
3 SGTC_1819 st053448 4.04 58.6 µM 2.78E-5 amide catabolism 19 2.69E-5
4 SGTC_2762 leflunomide 3.89 42.1 µM 5.27E-5 31 5.10E-5
5 SGTC_6 0844-0013 3.76 19.8 µM 8.66E-5 107 8.37E-5
6 SGTC_360 0957-0399 3.60 1.0 µM 1.63E-4 cell wall 55 1.57E-4
7 SGTC_2857 9024691 3.31 58.4 µM 4.85E-4 46 4.66E-4
8 SGTC_3156 9099931 3.29 49.5 µM 5.13E-4 24 4.93E-4
9 SGTC_1258 0671-0043 3.17 57.1 µM 8.06E-4 63 7.73E-4
10 SGTC_37 0566-0070 3.12 1.6 µM 9.48E-4 68 9.10E-4
11 SGTC_1975 st070967 3.11 30.8 µM 9.63E-4 74 9.23E-4
12 SGTC_1323 1348-1351 3.10 11.2 µM 0.00101 27 9.67E-4
13 SGTC_3022 9087993 3.07 49.5 µM 0.00111 25 0.00106
14 SGTC_508 roscovitine 3.04 141.0 µM 0.00123 22 0.00118
15 SGTC_757 1066-0008 3.03 322.0 µM 0.00130 Golgi 61 0.00124
16 SGTC_460 trequinsin 2.97 123.0 µM 0.00153 19 0.00147
17 SGTC_2591 skatole 2.96 100.0 µM 0.00160 74 0.00154
18 SGTC_759 3486-0358 2.93 89.3 µM 0.00176 62 0.00169
19 SGTC_1911 st060208 2.89 74.3 µM 0.00201 79 0.00193
20 SGTC_315 k915-0449 2.80 187.0 µM 0.00264 130 0.00253

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.242 6.77E-46 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.238 1.96E-44 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.231 9.17E-42 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.227 1.54E-40 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.215 2.03E-36 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.209 2.53E-34 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.206 1.49E-33 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.206 2.15E-33 YKL215C OXP1 hom 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.197 1.34E-30 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.196 1.70E-30 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.194 7.47E-30 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.190 1.14E-28 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.190 1.28E-28 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.178 2.76E-25 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.177 5.52E-25 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication