YKL212W / SAC1

Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL212W / SAC1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:6.10|P-value:1.83E-5 ID:SGTC_33|Compound:0986-0033|FD-Score:8.39|P-value:5.74E-9 ID:SGTC_39|Compound:0986-0283|FD-Score:5.20|P-value:2.21E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:11.90|P-value:2.37E-16 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.84|P-value:2.47E-8 ID:SGTC_72|Compound:0744-0168|FD-Score:7.02|P-value:9.62E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.52|P-value:7.47E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:4.75|P-value:6.79E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.02|P-value:3.56E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.70|P-value:5.82E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:6.12|P-value:1.72E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:8.70|P-value:1.63E-9 ID:SGTC_207|Compound:4185-0010|FD-Score:6.56|P-value:4.34E-6 ID:SGTC_218|Compound:alverine citrate|FD-Score:9.75|P-value:1.54E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-4.44|P-value:9.13E-4 ID:SGTC_232|Compound:clozapine|FD-Score:8.86|P-value:8.29E-10 ID:SGTC_234|Compound:nsc-17383|FD-Score:10.70|P-value:1.80E-13 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.94|P-value:4.35E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:5.34|P-value:1.53E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.59|P-value:9.92E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:6.67|P-value:3.03E-6 ID:SGTC_397|Compound:arbidol|FD-Score:5.17|P-value:2.40E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:5.43|P-value:1.22E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.29|P-value:1.06E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:7.20|P-value:5.16E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:6.30|P-value:9.82E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:4.72|P-value:7.34E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:9.98|P-value:5.29E-12 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.77|P-value:4.13E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:5.42|P-value:1.23E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:5.79|P-value:4.45E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:5.22|P-value:2.13E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:4.65|P-value:8.68E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:10.90|P-value:4.40E-14 ID:SGTC_665|Compound:3914-0008|FD-Score:9.50|P-value:5.03E-11 ID:SGTC_701|Compound:4424-0219|FD-Score:6.46|P-value:6.09E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:8.98|P-value:4.94E-10 ID:SGTC_824|Compound:1304-0008|FD-Score:5.23|P-value:2.04E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:7.49|P-value:1.86E-7 ID:SGTC_863|Compound:0466-0191|FD-Score:4.96|P-value:4.13E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:11.30|P-value:5.19E-15 ID:SGTC_954|Compound:1189-0853|FD-Score:9.10|P-value:2.92E-10 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.01|P-value:3.65E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.72|P-value:7.27E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:6.92|P-value:1.34E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:7.22|P-value:4.73E-7 ID:SGTC_1074|Compound:carmofur|FD-Score:5.77|P-value:4.68E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.00|P-value:3.73E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:8.37|P-value:6.20E-9 ID:SGTC_1247|Compound:0448-0043|FD-Score:6.31|P-value:9.57E-6 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.64|P-value:8.90E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.12|P-value:2.75E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.59|P-value:9.87E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:6.01|P-value:2.40E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.68|P-value:8.00E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.79|P-value:6.14E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:5.50|P-value:1.01E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:6.97|P-value:1.12E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.81|P-value:5.90E-4 ID:SGTC_1547|Compound:harmine|FD-Score:7.99|P-value:2.77E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:9.43|P-value:6.87E-11 ID:SGTC_1614|Compound:st002383|FD-Score:5.00|P-value:3.72E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.70|P-value:7.70E-4 ID:SGTC_1624|Compound:st003710|FD-Score:6.00|P-value:2.47E-5 ID:SGTC_1625|Compound:st003711|FD-Score:10.90|P-value:5.08E-14 ID:SGTC_1626|Compound:st003712|FD-Score:13.50|P-value:1.81E-20 ID:SGTC_1627|Compound:st003713|FD-Score:12.20|P-value:4.62E-17 ID:SGTC_1638|Compound:st008370|FD-Score:10.30|P-value:8.87E-13 ID:SGTC_1665|Compound:st014639|FD-Score:7.48|P-value:1.86E-7 ID:SGTC_1666|Compound:st014829|FD-Score:9.43|P-value:6.80E-11 ID:SGTC_1687|Compound:st020778|FD-Score:7.69|P-value:8.82E-8 ID:SGTC_1754|Compound:st042065|FD-Score:5.06|P-value:3.17E-4 ID:SGTC_1760|Compound:st045453|FD-Score:8.36|P-value:6.55E-9 ID:SGTC_1781|Compound:st038725|FD-Score:7.75|P-value:7.06E-8 ID:SGTC_1826|Compound:st055655|FD-Score:6.64|P-value:3.35E-6 ID:SGTC_1831|Compound:st055328|FD-Score:5.33|P-value:1.60E-4 ID:SGTC_1850|Compound:st056238|FD-Score:5.84|P-value:3.90E-5 ID:SGTC_1863|Compound:st057641|FD-Score:4.66|P-value:8.54E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:10.70|P-value:1.38E-13 ID:SGTC_1874|Compound:staurosporine|FD-Score:11.70|P-value:5.97E-16 ID:SGTC_1876|Compound:myriocin|FD-Score:-5.71|P-value:3.31E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.38|P-value:7.61E-6 ID:SGTC_1966|Compound:st070145|FD-Score:6.97|P-value:1.13E-6 ID:SGTC_1991|Compound:st073000|FD-Score:12.90|P-value:6.68E-19 ID:SGTC_1993|Compound:st073995|FD-Score:5.91|P-value:3.19E-5 ID:SGTC_2006|Compound:4011487|FD-Score:6.89|P-value:1.50E-6 ID:SGTC_2036|Compound:5160441|FD-Score:6.18|P-value:1.43E-5 ID:SGTC_2144|Compound:5628481|FD-Score:5.13|P-value:2.65E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.81|P-value:5.94E-4 ID:SGTC_2183|Compound:6420625|FD-Score:5.49|P-value:1.02E-4 ID:SGTC_2193|Compound:5925765|FD-Score:5.09|P-value:2.99E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.70|P-value:7.70E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.73|P-value:7.13E-4 ID:SGTC_2246|Compound:7293507|FD-Score:5.44|P-value:1.18E-4 ID:SGTC_2269|Compound:7935389|FD-Score:5.25|P-value:1.95E-4 ID:SGTC_2300|Compound:7976697|FD-Score:10.30|P-value:9.18E-13 ID:SGTC_2320|Compound:7373003|FD-Score:5.13|P-value:2.65E-4 ID:SGTC_2322|Compound:7413319|FD-Score:12.00|P-value:1.31E-16 ID:SGTC_2352|Compound:9027995|FD-Score:6.49|P-value:5.49E-6 ID:SGTC_2374|Compound:9071832|FD-Score:6.25|P-value:1.17E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.63|P-value:9.15E-4 ID:SGTC_2457|Compound:5731572|FD-Score:7.53|P-value:1.60E-7 ID:SGTC_2466|Compound:5983409|FD-Score:10.10|P-value:2.91E-12 ID:SGTC_2474|Compound:5321570|FD-Score:5.40|P-value:1.31E-4 ID:SGTC_2526|Compound:patulin|FD-Score:6.04|P-value:2.14E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:5.09|P-value:2.99E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.65|P-value:5.50E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:8.15|P-value:1.51E-8 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.82|P-value:5.78E-4 ID:SGTC_2694|Compound:st077685|FD-Score:5.32|P-value:1.64E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.64|P-value:3.34E-6 ID:SGTC_2699|Compound:st077704|FD-Score:5.30|P-value:1.73E-4 ID:SGTC_2838|Compound:9002687|FD-Score:6.29|P-value:1.03E-5 ID:SGTC_2853|Compound:9015042|FD-Score:5.98|P-value:2.58E-5 ID:SGTC_2862|Compound:9027634|FD-Score:6.99|P-value:1.06E-6 ID:SGTC_2868|Compound:9035608|FD-Score:6.40|P-value:7.19E-6 ID:SGTC_2873|Compound:9040596|FD-Score:6.62|P-value:3.56E-6 ID:SGTC_2896|Compound:9052656|FD-Score:4.62|P-value:9.27E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.73|P-value:7.24E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.79|P-value:6.16E-4 ID:SGTC_2973|Compound:9094665|FD-Score:8.94|P-value:5.99E-10 ID:SGTC_3018|Compound:9082602|FD-Score:4.77|P-value:6.56E-4 ID:SGTC_3126|Compound:9127922|FD-Score:9.10|P-value:2.89E-10 ID:SGTC_3145|Compound:9085516|FD-Score:10.80|P-value:1.16E-13 ID:SGTC_3154|Compound:9100113|FD-Score:4.69|P-value:7.91E-4 ID:SGTC_3218|Compound:9131285|FD-Score:9.41|P-value:7.43E-11 ID:SGTC_3219|Compound:9131112|FD-Score:-4.88|P-value:3.12E-4 ID:SGTC_3236|Compound:9132701|FD-Score:5.21|P-value:2.18E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.30|P-value:1.03E-4 ID:SGTC_3280|Compound:9140961|FD-Score:5.68|P-value:6.19E-5 ID:SGTC_3308|Compound:9128332|FD-Score:12.20|P-value:4.80E-17 ID:SGTC_3309|Compound:9129340|FD-Score:10.90|P-value:5.72E-14 ID:SGTC_3316|Compound:9136639|FD-Score:5.48|P-value:1.05E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:6.10|P-value:1.83E-5 ID:SGTC_33|Compound:0986-0033|FD-Score:8.39|P-value:5.74E-9 ID:SGTC_39|Compound:0986-0283|FD-Score:5.20|P-value:2.21E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:11.90|P-value:2.37E-16 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.84|P-value:2.47E-8 ID:SGTC_72|Compound:0744-0168|FD-Score:7.02|P-value:9.62E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.52|P-value:7.47E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:4.75|P-value:6.79E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.02|P-value:3.56E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.70|P-value:5.82E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:6.12|P-value:1.72E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:8.70|P-value:1.63E-9 ID:SGTC_207|Compound:4185-0010|FD-Score:6.56|P-value:4.34E-6 ID:SGTC_218|Compound:alverine citrate|FD-Score:9.75|P-value:1.54E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-4.44|P-value:9.13E-4 ID:SGTC_232|Compound:clozapine|FD-Score:8.86|P-value:8.29E-10 ID:SGTC_234|Compound:nsc-17383|FD-Score:10.70|P-value:1.80E-13 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.94|P-value:4.35E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:5.34|P-value:1.53E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.59|P-value:9.92E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:6.67|P-value:3.03E-6 ID:SGTC_397|Compound:arbidol|FD-Score:5.17|P-value:2.40E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:5.43|P-value:1.22E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.29|P-value:1.06E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:7.20|P-value:5.16E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:6.30|P-value:9.82E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:4.72|P-value:7.34E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:9.98|P-value:5.29E-12 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.77|P-value:4.13E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:5.42|P-value:1.23E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:5.79|P-value:4.45E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:5.22|P-value:2.13E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:4.65|P-value:8.68E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:10.90|P-value:4.40E-14 ID:SGTC_665|Compound:3914-0008|FD-Score:9.50|P-value:5.03E-11 ID:SGTC_701|Compound:4424-0219|FD-Score:6.46|P-value:6.09E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:8.98|P-value:4.94E-10 ID:SGTC_824|Compound:1304-0008|FD-Score:5.23|P-value:2.04E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:7.49|P-value:1.86E-7 ID:SGTC_863|Compound:0466-0191|FD-Score:4.96|P-value:4.13E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:11.30|P-value:5.19E-15 ID:SGTC_954|Compound:1189-0853|FD-Score:9.10|P-value:2.92E-10 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.01|P-value:3.65E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.72|P-value:7.27E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:6.92|P-value:1.34E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:7.22|P-value:4.73E-7 ID:SGTC_1074|Compound:carmofur|FD-Score:5.77|P-value:4.68E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.00|P-value:3.73E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:8.37|P-value:6.20E-9 ID:SGTC_1247|Compound:0448-0043|FD-Score:6.31|P-value:9.57E-6 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.64|P-value:8.90E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.12|P-value:2.75E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.59|P-value:9.87E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:6.01|P-value:2.40E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.68|P-value:8.00E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.79|P-value:6.14E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:5.50|P-value:1.01E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:6.97|P-value:1.12E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.81|P-value:5.90E-4 ID:SGTC_1547|Compound:harmine|FD-Score:7.99|P-value:2.77E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:9.43|P-value:6.87E-11 ID:SGTC_1614|Compound:st002383|FD-Score:5.00|P-value:3.72E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.70|P-value:7.70E-4 ID:SGTC_1624|Compound:st003710|FD-Score:6.00|P-value:2.47E-5 ID:SGTC_1625|Compound:st003711|FD-Score:10.90|P-value:5.08E-14 ID:SGTC_1626|Compound:st003712|FD-Score:13.50|P-value:1.81E-20 ID:SGTC_1627|Compound:st003713|FD-Score:12.20|P-value:4.62E-17 ID:SGTC_1638|Compound:st008370|FD-Score:10.30|P-value:8.87E-13 ID:SGTC_1665|Compound:st014639|FD-Score:7.48|P-value:1.86E-7 ID:SGTC_1666|Compound:st014829|FD-Score:9.43|P-value:6.80E-11 ID:SGTC_1687|Compound:st020778|FD-Score:7.69|P-value:8.82E-8 ID:SGTC_1754|Compound:st042065|FD-Score:5.06|P-value:3.17E-4 ID:SGTC_1760|Compound:st045453|FD-Score:8.36|P-value:6.55E-9 ID:SGTC_1781|Compound:st038725|FD-Score:7.75|P-value:7.06E-8 ID:SGTC_1826|Compound:st055655|FD-Score:6.64|P-value:3.35E-6 ID:SGTC_1831|Compound:st055328|FD-Score:5.33|P-value:1.60E-4 ID:SGTC_1850|Compound:st056238|FD-Score:5.84|P-value:3.90E-5 ID:SGTC_1863|Compound:st057641|FD-Score:4.66|P-value:8.54E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:10.70|P-value:1.38E-13 ID:SGTC_1874|Compound:staurosporine|FD-Score:11.70|P-value:5.97E-16 ID:SGTC_1876|Compound:myriocin|FD-Score:-5.71|P-value:3.31E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.38|P-value:7.61E-6 ID:SGTC_1966|Compound:st070145|FD-Score:6.97|P-value:1.13E-6 ID:SGTC_1991|Compound:st073000|FD-Score:12.90|P-value:6.68E-19 ID:SGTC_1993|Compound:st073995|FD-Score:5.91|P-value:3.19E-5 ID:SGTC_2006|Compound:4011487|FD-Score:6.89|P-value:1.50E-6 ID:SGTC_2036|Compound:5160441|FD-Score:6.18|P-value:1.43E-5 ID:SGTC_2144|Compound:5628481|FD-Score:5.13|P-value:2.65E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.81|P-value:5.94E-4 ID:SGTC_2183|Compound:6420625|FD-Score:5.49|P-value:1.02E-4 ID:SGTC_2193|Compound:5925765|FD-Score:5.09|P-value:2.99E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.70|P-value:7.70E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.73|P-value:7.13E-4 ID:SGTC_2246|Compound:7293507|FD-Score:5.44|P-value:1.18E-4 ID:SGTC_2269|Compound:7935389|FD-Score:5.25|P-value:1.95E-4 ID:SGTC_2300|Compound:7976697|FD-Score:10.30|P-value:9.18E-13 ID:SGTC_2320|Compound:7373003|FD-Score:5.13|P-value:2.65E-4 ID:SGTC_2322|Compound:7413319|FD-Score:12.00|P-value:1.31E-16 ID:SGTC_2352|Compound:9027995|FD-Score:6.49|P-value:5.49E-6 ID:SGTC_2374|Compound:9071832|FD-Score:6.25|P-value:1.17E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.63|P-value:9.15E-4 ID:SGTC_2457|Compound:5731572|FD-Score:7.53|P-value:1.60E-7 ID:SGTC_2466|Compound:5983409|FD-Score:10.10|P-value:2.91E-12 ID:SGTC_2474|Compound:5321570|FD-Score:5.40|P-value:1.31E-4 ID:SGTC_2526|Compound:patulin|FD-Score:6.04|P-value:2.14E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:5.09|P-value:2.99E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.65|P-value:5.50E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:8.15|P-value:1.51E-8 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.82|P-value:5.78E-4 ID:SGTC_2694|Compound:st077685|FD-Score:5.32|P-value:1.64E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.64|P-value:3.34E-6 ID:SGTC_2699|Compound:st077704|FD-Score:5.30|P-value:1.73E-4 ID:SGTC_2838|Compound:9002687|FD-Score:6.29|P-value:1.03E-5 ID:SGTC_2853|Compound:9015042|FD-Score:5.98|P-value:2.58E-5 ID:SGTC_2862|Compound:9027634|FD-Score:6.99|P-value:1.06E-6 ID:SGTC_2868|Compound:9035608|FD-Score:6.40|P-value:7.19E-6 ID:SGTC_2873|Compound:9040596|FD-Score:6.62|P-value:3.56E-6 ID:SGTC_2896|Compound:9052656|FD-Score:4.62|P-value:9.27E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.73|P-value:7.24E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.79|P-value:6.16E-4 ID:SGTC_2973|Compound:9094665|FD-Score:8.94|P-value:5.99E-10 ID:SGTC_3018|Compound:9082602|FD-Score:4.77|P-value:6.56E-4 ID:SGTC_3126|Compound:9127922|FD-Score:9.10|P-value:2.89E-10 ID:SGTC_3145|Compound:9085516|FD-Score:10.80|P-value:1.16E-13 ID:SGTC_3154|Compound:9100113|FD-Score:4.69|P-value:7.91E-4 ID:SGTC_3218|Compound:9131285|FD-Score:9.41|P-value:7.43E-11 ID:SGTC_3219|Compound:9131112|FD-Score:-4.88|P-value:3.12E-4 ID:SGTC_3236|Compound:9132701|FD-Score:5.21|P-value:2.18E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.30|P-value:1.03E-4 ID:SGTC_3280|Compound:9140961|FD-Score:5.68|P-value:6.19E-5 ID:SGTC_3308|Compound:9128332|FD-Score:12.20|P-value:4.80E-17 ID:SGTC_3309|Compound:9129340|FD-Score:10.90|P-value:5.72E-14 ID:SGTC_3316|Compound:9136639|FD-Score:5.48|P-value:1.05E-4

Top fitness defect scores for YKL212W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1626 st003712 13.50 1.8 µM 1.81E-20 1 1.17E-41
2 SGTC_1991 st073000 12.90 8.9 µM 6.68E-19 NEO1 7 2.42E-38
3 SGTC_1627 st003713 12.20 25.6 µM 4.62E-17 calcium & mitochondrial duress 5 1.89E-34
4 SGTC_3308 9128332 12.20 17.6 µM 4.80E-17 plasma membrane duress 16 2.05E-34
5 SGTC_2322 7413319 12.00 38.2 µM 1.31E-16 ERAD & cell cycle 9 1.71E-33
6 SGTC_54 0159-0055 11.90 9.0 µM 2.37E-16 ERG2 8 5.99E-33
7 SGTC_1874 staurosporine 11.70 7.6 µM 5.97E-16 cell wall signaling 4 4.24E-32
8 SGTC_908 3448-7491 11.30 47.7 µM 5.19E-15 mitochondrial stress 4 4.10E-30
9 SGTC_658 3253-0951 10.90 102.0 µM 4.40E-14 calcium & mitochondrial duress 2 3.77E-28
10 SGTC_1625 st003711 10.90 30.1 µM 5.08E-14 calcium & mitochondrial duress 1 5.10E-28
11 SGTC_3309 9129340 10.90 25.8 µM 5.72E-14 1 6.55E-28
12 SGTC_3145 9085516 10.80 49.5 µM 1.16E-13 fatty acid desaturase (OLE1) 1 2.94E-27
13 SGTC_1873 rapamycin 10.70 2.0 nM 1.38E-13 6 4.24E-27
14 SGTC_234 nsc-17383 10.70 10.7 µM 1.80E-13 ERG2 4 7.38E-27
15 SGTC_1638 st008370 10.30 60.6 µM 8.87E-13 ergosterol biosynthesis 2 2.15E-25
16 SGTC_2300 7976697 10.30 71.6 µM 9.18E-13 ERG2 4 2.31E-25
17 SGTC_2466 5983409 10.10 37.1 µM 2.91E-12 1 2.65E-24
18 SGTC_582 0987-0078 9.98 156.0 µM 5.29E-12 calcium & mitochondrial duress 9 9.33E-24
19 SGTC_218 alverine citrate 9.75 93.8 µM 1.54E-11 fatty acid desaturase (OLE1) 4 8.88E-23
20 SGTC_665 3914-0008 9.50 307.0 µM 5.03E-11 1 1.08E-21

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.383 2.75E-117 YMR202W ERG2 hom C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
0.336 1.80E-89 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
0.314 2.10E-77 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.288 6.99E-65 YNL323W LEM3 hom Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
0.270 6.52E-57 YGL054C ERV14 hom COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication
0.257 6.57E-52 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.257 7.39E-52 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
0.246 2.07E-47 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.236 1.05E-43 YKL126W YPK1 hom Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication
0.235 3.11E-43 YGL012W ERG4 hom C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
0.231 5.28E-42 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.225 1.04E-39 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.223 3.43E-39 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.221 1.96E-38 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.220 3.56E-38 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication