YKL222C

Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL222C / YKL222C

Click on Significant Values for Screen Details ID:SGTC_96|Compound:0929-0093|FD-Score:-3.25|P-value:7.22E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.17|P-value:9.04E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:5.87|P-value:3.83E-9 ID:SGTC_369|Compound:0957-0393|FD-Score:4.37|P-value:8.55E-6 ID:SGTC_674|Compound:0498-0004|FD-Score:3.40|P-value:4.08E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.37|P-value:4.47E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.64|P-value:1.66E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.23|P-value:7.28E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.89|P-value:6.45E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:16.60|P-value:4.22E-60 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.65|P-value:1.59E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.52|P-value:2.66E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.17|P-value:8.89E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.29|P-value:1.21E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.25|P-value:7.17E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.20|P-value:8.54E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.17|P-value:9.56E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-4.84|P-value:1.03E-6 ID:SGTC_1660|Compound:st012960|FD-Score:-3.26|P-value:7.05E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.85|P-value:7.35E-5 ID:SGTC_2047|Compound:4141938|FD-Score:-3.47|P-value:3.38E-4 ID:SGTC_2065|Compound:5221596|FD-Score:5.28|P-value:9.91E-8 ID:SGTC_2292|Compound:7671323|FD-Score:3.76|P-value:1.07E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.37|P-value:4.53E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.89|P-value:6.85E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-3.21|P-value:8.24E-4 ID:SGTC_2415|Compound:st077333|FD-Score:6.26|P-value:3.71E-10 ID:SGTC_2416|Compound:tofa|FD-Score:-6.70|P-value:2.43E-11 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.83|P-value:8.07E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.45|P-value:3.43E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.60|P-value:3.01E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.31|P-value:1.08E-5 ID:SGTC_2585|Compound:alliin|FD-Score:-3.62|P-value:1.93E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.45|P-value:5.84E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:7.34|P-value:2.64E-13 ID:SGTC_2624|Compound:nerol|FD-Score:-3.60|P-value:2.07E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.24|P-value:7.00E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.75|P-value:1.11E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.18|P-value:8.60E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.42|P-value:3.98E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.40|P-value:4.01E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:-3.25|P-value:7.22E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.17|P-value:9.04E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:5.87|P-value:3.83E-9 ID:SGTC_369|Compound:0957-0393|FD-Score:4.37|P-value:8.55E-6 ID:SGTC_674|Compound:0498-0004|FD-Score:3.40|P-value:4.08E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.37|P-value:4.47E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.64|P-value:1.66E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.23|P-value:7.28E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.89|P-value:6.45E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:16.60|P-value:4.22E-60 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.65|P-value:1.59E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.52|P-value:2.66E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.17|P-value:8.89E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.29|P-value:1.21E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.25|P-value:7.17E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.20|P-value:8.54E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.17|P-value:9.56E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-4.84|P-value:1.03E-6 ID:SGTC_1660|Compound:st012960|FD-Score:-3.26|P-value:7.05E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.85|P-value:7.35E-5 ID:SGTC_2047|Compound:4141938|FD-Score:-3.47|P-value:3.38E-4 ID:SGTC_2065|Compound:5221596|FD-Score:5.28|P-value:9.91E-8 ID:SGTC_2292|Compound:7671323|FD-Score:3.76|P-value:1.07E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.37|P-value:4.53E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.89|P-value:6.85E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-3.21|P-value:8.24E-4 ID:SGTC_2415|Compound:st077333|FD-Score:6.26|P-value:3.71E-10 ID:SGTC_2416|Compound:tofa|FD-Score:-6.70|P-value:2.43E-11 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.83|P-value:8.07E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.45|P-value:3.43E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.60|P-value:3.01E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.31|P-value:1.08E-5 ID:SGTC_2585|Compound:alliin|FD-Score:-3.62|P-value:1.93E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.45|P-value:5.84E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:7.34|P-value:2.64E-13 ID:SGTC_2624|Compound:nerol|FD-Score:-3.60|P-value:2.07E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.24|P-value:7.00E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.75|P-value:1.11E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.18|P-value:8.60E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.42|P-value:3.98E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.40|P-value:4.01E-4

Top fitness defect scores for YKL222C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1121 fusaric acid 16.60 630.5 nM 4.22E-60 4 4.26E-62
2 SGTC_2621 lithochol-11-enic acid 7.34 100.0 µM 2.64E-13 1 1.10E-13
3 SGTC_2415 st077333 6.26 57.7 µM 3.71E-10 11 1.97E-10
4 SGTC_366 0181-0206 5.87 4.3 µM 3.83E-9 Golgi 9 2.20E-9
5 SGTC_2065 5221596 5.28 34.3 µM 9.91E-8 3 6.33E-8
6 SGTC_2536 dehydroabietamide 4.60 32.0 µM 3.01E-6 15 2.15E-6
7 SGTC_2589 lobaric acid 4.45 100.0 µM 5.84E-6 17 4.26E-6
8 SGTC_369 0957-0393 4.37 4.5 µM 8.55E-6 cell wall signaling 16 6.31E-6
9 SGTC_2569 tetrandrine 4.31 100.0 µM 1.08E-5 15 8.01E-6
10 SGTC_1368 1852-0141 4.29 284.0 µM 1.21E-5 ERG2 32 9.00E-6
11 SGTC_959 1222-0044 3.89 107.0 µM 6.45E-5 22 5.08E-5
12 SGTC_1913 st060213 3.85 96.1 µM 7.35E-5 33 5.82E-5
13 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.83 63.6 µM 8.07E-5 49 6.41E-5
14 SGTC_2292 7671323 3.76 168.1 µM 1.07E-4 RNA processing & uracil transport 39 8.59E-5
15 SGTC_2775 cyproheptadine 3.75 69.6 µM 1.11E-4 22 8.87E-5
16 SGTC_1176 0848-0131 3.65 83.3 µM 1.59E-4 Golgi 28 1.29E-4
17 SGTC_747 3448-8087 3.64 38.7 µM 1.66E-4 34 1.35E-4
18 SGTC_1246 0422-0085 3.52 105.0 µM 2.66E-4 50 2.19E-4
19 SGTC_2532 xanthone 3.45 78.9 µM 3.43E-4 44 2.84E-4
20 SGTC_3319 9138450 3.40 16.8 µM 4.01E-4 35 3.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.344 8.62E-94 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.330 3.50E-86 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.292 5.06E-67 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.260 5.65E-53 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.131 2.48E-14 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.127 1.48E-13 YMR087W YMR087W hom Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain
0.125 4.13E-13 YGL159W_p YGL159W_p hom Putative protein of unknown function; deletion mutant has no detectable phenotype
0.124 5.64E-13 YLR079W SIC1 hom Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
0.123 9.27E-13 YGR226C_d YGR226C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
0.122 1.09E-12 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.116 1.43E-11 YNL094W APP1 hom Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
0.111 1.02E-10 YNR038W DBP6 het Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
0.108 3.15E-10 YPL194W DDC1 hom DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
0.107 5.31E-10 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.107 5.40E-10 YPR031W NTO1 hom Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3