YKR009C / FOX2

Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR009C / FOX2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:6.39|P-value:8.25E-14 ID:SGTC_32|Compound:0928-0142|FD-Score:5.66|P-value:3.12E-11 ID:SGTC_152|Compound:4469-0003|FD-Score:3.78|P-value:6.23E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:3.79|P-value:5.89E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:2.94|P-value:3.38E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-2.89|P-value:4.83E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:2.83|P-value:5.13E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:2.84|P-value:4.91E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.12|P-value:1.54E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-2.95|P-value:3.73E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:2.98|P-value:2.82E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.62|P-value:4.76E-8 ID:SGTC_1231|Compound:0242-0792|FD-Score:2.84|P-value:4.94E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.30|P-value:6.65E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.06|P-value:2.02E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:5.85|P-value:7.50E-12 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.01|P-value:2.92E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.11|P-value:1.04E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-2.95|P-value:3.80E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:2.89|P-value:4.10E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.40|P-value:5.12E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.47|P-value:1.21E-7 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.61|P-value:1.86E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.29|P-value:4.58E-7 ID:SGTC_1563|Compound:conessine|FD-Score:2.77|P-value:6.60E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.28|P-value:7.41E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.00|P-value:2.60E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:2.88|P-value:4.33E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-2.84|P-value:5.97E-4 ID:SGTC_2319|Compound:6033012|FD-Score:2.83|P-value:5.21E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.78|P-value:6.25E-6 ID:SGTC_2426|Compound:5582046|FD-Score:-3.62|P-value:1.71E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.94|P-value:3.49E-12 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.78|P-value:6.29E-4 ID:SGTC_2954|Compound:9074818|FD-Score:6.52|P-value:2.57E-14 ID:SGTC_2955|Compound:9076254|FD-Score:-5.27|P-value:7.80E-10 ID:SGTC_2957|Compound:9076800|FD-Score:-3.94|P-value:3.32E-6 ID:SGTC_2969|Compound:9091408|FD-Score:5.81|P-value:9.70E-12 ID:SGTC_2998|Compound:9066762|FD-Score:3.18|P-value:1.14E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-4.86|P-value:1.33E-8 ID:SGTC_3194|Compound:9111903|FD-Score:-3.33|P-value:6.90E-5 ID:SGTC_3205|Compound:9113483|FD-Score:4.00|P-value:1.84E-6 ID:SGTC_3291|Compound:9121177|FD-Score:3.34|P-value:5.53E-5 ID:SGTC_3293|Compound:9120939|FD-Score:3.97|P-value:2.25E-6 ID:SGTC_3298|Compound:9116858|FD-Score:3.17|P-value:1.21E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:6.39|P-value:8.25E-14 ID:SGTC_32|Compound:0928-0142|FD-Score:5.66|P-value:3.12E-11 ID:SGTC_152|Compound:4469-0003|FD-Score:3.78|P-value:6.23E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:3.79|P-value:5.89E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:2.94|P-value:3.38E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-2.89|P-value:4.83E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:2.83|P-value:5.13E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:2.84|P-value:4.91E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.12|P-value:1.54E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-2.95|P-value:3.73E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:2.98|P-value:2.82E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.62|P-value:4.76E-8 ID:SGTC_1231|Compound:0242-0792|FD-Score:2.84|P-value:4.94E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.30|P-value:6.65E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.06|P-value:2.02E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:5.85|P-value:7.50E-12 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.01|P-value:2.92E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.11|P-value:1.04E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-2.95|P-value:3.80E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:2.89|P-value:4.10E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.40|P-value:5.12E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.47|P-value:1.21E-7 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.61|P-value:1.86E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.29|P-value:4.58E-7 ID:SGTC_1563|Compound:conessine|FD-Score:2.77|P-value:6.60E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.28|P-value:7.41E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.00|P-value:2.60E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:2.88|P-value:4.33E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-2.84|P-value:5.97E-4 ID:SGTC_2319|Compound:6033012|FD-Score:2.83|P-value:5.21E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.78|P-value:6.25E-6 ID:SGTC_2426|Compound:5582046|FD-Score:-3.62|P-value:1.71E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.94|P-value:3.49E-12 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.78|P-value:6.29E-4 ID:SGTC_2954|Compound:9074818|FD-Score:6.52|P-value:2.57E-14 ID:SGTC_2955|Compound:9076254|FD-Score:-5.27|P-value:7.80E-10 ID:SGTC_2957|Compound:9076800|FD-Score:-3.94|P-value:3.32E-6 ID:SGTC_2969|Compound:9091408|FD-Score:5.81|P-value:9.70E-12 ID:SGTC_2998|Compound:9066762|FD-Score:3.18|P-value:1.14E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-4.86|P-value:1.33E-8 ID:SGTC_3194|Compound:9111903|FD-Score:-3.33|P-value:6.90E-5 ID:SGTC_3205|Compound:9113483|FD-Score:4.00|P-value:1.84E-6 ID:SGTC_3291|Compound:9121177|FD-Score:3.34|P-value:5.53E-5 ID:SGTC_3293|Compound:9120939|FD-Score:3.97|P-value:2.25E-6 ID:SGTC_3298|Compound:9116858|FD-Score:3.17|P-value:1.21E-4

Top fitness defect scores for YKR009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2954 9074818 6.52 52.7 µM 2.57E-14 9 3.41E-11
2 SGTC_6 0844-0013 6.39 19.8 µM 8.25E-14 10 8.25E-11
3 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.94 3.7 µM 3.49E-12 13 1.41E-9
4 SGTC_1336 1486-0901 5.85 104.0 µM 7.50E-12 7 2.52E-9
5 SGTC_2969 9091408 5.81 28.7 µM 9.70E-12 4 3.06E-9
6 SGTC_32 0928-0142 5.66 34.1 µM 3.12E-11 TSC3-RPN4 3 7.41E-9
7 SGTC_1195 1502-0147 4.62 41.1 µM 4.76E-8 11 1.93E-6
8 SGTC_1445 4239-0156 4.47 97.7 µM 1.21E-7 19 3.94E-6
9 SGTC_1364 1653-0028 4.11 37.6 µM 1.04E-6 17 2.02E-5
10 SGTC_3205 9113483 4.00 49.5 µM 1.84E-6 26 3.11E-5
11 SGTC_3293 9120939 3.97 62.0 µM 2.25E-6 21 3.63E-5
12 SGTC_153 4077-0274 3.79 519.7 µM 5.89E-6 17 7.56E-5
13 SGTC_152 4469-0003 3.78 551.2 µM 6.23E-6 28 7.89E-5
14 SGTC_2363 9053361 3.78 176.0 µM 6.25E-6 Golgi 34 7.91E-5
15 SGTC_3291 9121177 3.34 71.4 µM 5.53E-5 27 4.18E-4
16 SGTC_1259 0671-0132 3.30 43.0 µM 6.65E-5 52 4.81E-4
17 SGTC_1587 estradiol valerate 3.28 56.1 µM 7.41E-5 30 5.22E-4
18 SGTC_2998 9066762 3.18 71.4 µM 1.14E-4 RPP1 & pyrimidine depletion 56 7.27E-4
19 SGTC_3298 9116858 3.17 71.4 µM 1.21E-4 34 7.62E-4
20 SGTC_949 1165-0505 3.12 146.0 µM 1.54E-4 60 9.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 8.23E-31 YDR068W DOS2 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.160 9.04E-21 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.155 1.30E-19 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.152 8.27E-19 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.151 1.46E-18 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.140 3.26E-16 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.139 5.06E-16 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.137 1.30E-15 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.137 1.66E-15 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.136 2.49E-15 YKR064W OAF3 hom Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.130 4.50E-14 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.127 1.34E-13 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.126 2.44E-13 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.125 4.34E-13 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.123 1.04E-12 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity