YKR014C / YPT52

Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR014C / YPT52

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:5.42|P-value:9.82E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:6.69|P-value:6.91E-11 ID:SGTC_373|Compound:0844-0104|FD-Score:6.78|P-value:3.86E-11 ID:SGTC_384|Compound:k007-0144|FD-Score:5.60|P-value:3.79E-8 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.50|P-value:4.10E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.26|P-value:8.72E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.89|P-value:7.66E-9 ID:SGTC_689|Compound:0833-0039|FD-Score:3.26|P-value:8.56E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:6.57|P-value:1.46E-10 ID:SGTC_805|Compound:3852-0218|FD-Score:11.50|P-value:1.07E-28 ID:SGTC_852|Compound:0418-0143|FD-Score:3.27|P-value:8.26E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.24|P-value:9.32E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:5.33|P-value:1.54E-7 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.30|P-value:7.54E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-5.34|P-value:1.60E-7 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.24|P-value:9.16E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.24|P-value:9.30E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.55|P-value:3.21E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.84|P-value:2.59E-11 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.79|P-value:1.33E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.39|P-value:5.60E-4 ID:SGTC_1715|Compound:st032160|FD-Score:9.46|P-value:5.67E-20 ID:SGTC_1716|Compound:st033144|FD-Score:4.08|P-value:4.36E-5 ID:SGTC_1717|Compound:st033143|FD-Score:3.70|P-value:1.91E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.47|P-value:4.28E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.43|P-value:5.25E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.87|P-value:1.00E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.25|P-value:8.96E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.24|P-value:9.20E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.68|P-value:2.16E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.38|P-value:6.24E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.79|P-value:1.36E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.99|P-value:6.40E-5 ID:SGTC_2291|Compound:7917025|FD-Score:5.42|P-value:9.73E-8 ID:SGTC_2297|Compound:7971671|FD-Score:4.15|P-value:3.34E-5 ID:SGTC_2300|Compound:7976697|FD-Score:3.34|P-value:6.53E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.04|P-value:6.58E-7 ID:SGTC_2394|Compound:5221648|FD-Score:3.89|P-value:9.30E-5 ID:SGTC_2440|Compound:5628896|FD-Score:3.87|P-value:9.97E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-3.35|P-value:6.78E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.52|P-value:3.55E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.35|P-value:6.90E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.30|P-value:7.95E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.52|P-value:3.57E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.62|P-value:4.57E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.71|P-value:1.83E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.77|P-value:2.30E-6 ID:SGTC_2893|Compound:9048488|FD-Score:3.31|P-value:7.41E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.32|P-value:7.08E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.25|P-value:8.93E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.58|P-value:2.93E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.87|P-value:1.47E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:5.42|P-value:9.82E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:6.69|P-value:6.91E-11 ID:SGTC_373|Compound:0844-0104|FD-Score:6.78|P-value:3.86E-11 ID:SGTC_384|Compound:k007-0144|FD-Score:5.60|P-value:3.79E-8 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.50|P-value:4.10E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.26|P-value:8.72E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.89|P-value:7.66E-9 ID:SGTC_689|Compound:0833-0039|FD-Score:3.26|P-value:8.56E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:6.57|P-value:1.46E-10 ID:SGTC_805|Compound:3852-0218|FD-Score:11.50|P-value:1.07E-28 ID:SGTC_852|Compound:0418-0143|FD-Score:3.27|P-value:8.26E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.24|P-value:9.32E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:5.33|P-value:1.54E-7 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.30|P-value:7.54E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-5.34|P-value:1.60E-7 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.24|P-value:9.16E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.24|P-value:9.30E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.55|P-value:3.21E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.84|P-value:2.59E-11 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.79|P-value:1.33E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.39|P-value:5.60E-4 ID:SGTC_1715|Compound:st032160|FD-Score:9.46|P-value:5.67E-20 ID:SGTC_1716|Compound:st033144|FD-Score:4.08|P-value:4.36E-5 ID:SGTC_1717|Compound:st033143|FD-Score:3.70|P-value:1.91E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.47|P-value:4.28E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.43|P-value:5.25E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.87|P-value:1.00E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.25|P-value:8.96E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.24|P-value:9.20E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.68|P-value:2.16E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.38|P-value:6.24E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.79|P-value:1.36E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.99|P-value:6.40E-5 ID:SGTC_2291|Compound:7917025|FD-Score:5.42|P-value:9.73E-8 ID:SGTC_2297|Compound:7971671|FD-Score:4.15|P-value:3.34E-5 ID:SGTC_2300|Compound:7976697|FD-Score:3.34|P-value:6.53E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.04|P-value:6.58E-7 ID:SGTC_2394|Compound:5221648|FD-Score:3.89|P-value:9.30E-5 ID:SGTC_2440|Compound:5628896|FD-Score:3.87|P-value:9.97E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-3.35|P-value:6.78E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.52|P-value:3.55E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.35|P-value:6.90E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.30|P-value:7.95E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.52|P-value:3.57E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.62|P-value:4.57E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.71|P-value:1.83E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.77|P-value:2.30E-6 ID:SGTC_2893|Compound:9048488|FD-Score:3.31|P-value:7.41E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.32|P-value:7.08E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.25|P-value:8.93E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.58|P-value:2.93E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.87|P-value:1.47E-6

Top fitness defect scores for YKR014C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_805 3852-0218 11.50 479.0 µM 1.07E-28 ERAD & cell cycle 3 5.13E-31
2 SGTC_1715 st032160 9.46 10.2 µM 5.67E-20 7 1.55E-21
3 SGTC_1161 k007-0610 6.84 110.0 µM 2.59E-11 ERAD & cell cycle 42 3.94E-12
4 SGTC_373 0844-0104 6.78 25.9 µM 3.86E-11 ERAD & cell cycle 18 6.08E-12
5 SGTC_352 k048-0007 6.69 5.1 µM 6.91E-11 ERAD & cell cycle 24 1.14E-11
6 SGTC_733 4069-0007 6.57 56.1 µM 1.46E-10 ERAD & cell cycle 34 2.57E-11
7 SGTC_568 1193-0097 5.89 7.5 µM 7.66E-9 ERAD & cell cycle 62 1.89E-9
8 SGTC_384 k007-0144 5.60 5.2 µM 3.79E-8 ERAD & cell cycle 30 1.07E-8
9 SGTC_2291 7917025 5.42 104.3 µM 9.73E-8 iron homeostasis 27 2.97E-8
10 SGTC_103 0844-0104 5.42 51.8 µM 9.82E-8 ERAD & cell cycle 89 3.00E-8
11 SGTC_912 3474-0017 5.33 2.2 µM 1.54E-7 8 4.90E-8
12 SGTC_2322 7413319 5.04 38.2 µM 6.58E-7 ERAD & cell cycle 94 2.36E-7
13 SGTC_3197 9113331 4.87 49.5 µM 1.47E-6 19 5.64E-7
14 SGTC_2812 7970281 4.77 58.4 µM 2.30E-6 8 9.15E-7
15 SGTC_2721 ifenprodil 4.62 61.4 µM 4.57E-6 plasma membrane duress 10 1.92E-6
16 SGTC_2297 7971671 4.15 152.3 µM 3.34E-5 RNA processing & uracil transport 19 1.65E-5
17 SGTC_1716 st033144 4.08 30.6 µM 4.36E-5 20 2.21E-5
18 SGTC_2050 5263056 3.99 171.0 µM 6.40E-5 fatty acid desaturase (OLE1) 40 3.34E-5
19 SGTC_2394 5221648 3.89 200.0 µM 9.30E-5 23 5.01E-5
20 SGTC_2440 5628896 3.87 157.8 µM 9.97E-5 28 5.41E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.428 1.08E-149 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.412 4.61E-138 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.388 3.41E-121 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.383 1.77E-117 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.369 8.42E-109 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.359 2.25E-102 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.311 5.91E-76 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.305 5.97E-73 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.290 7.34E-66 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.275 1.87E-59 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.253 3.12E-50 YLR065C ENV10 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene
0.252 1.54E-49 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.252 1.58E-49 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.244 1.20E-46 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.241 1.67E-45 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria