YKR042W / UTH1

Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR042W / UTH1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:19.00|P-value:8.92E-87 ID:SGTC_81|Compound:0411-0046|FD-Score:-3.08|P-value:7.26E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:5.59|P-value:2.99E-9 ID:SGTC_99|Compound:0109-0120|FD-Score:4.88|P-value:1.93E-7 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.27|P-value:3.60E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.51|P-value:1.29E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.62|P-value:2.94E-12 ID:SGTC_138|Compound:0850-0259|FD-Score:10.60|P-value:1.49E-28 ID:SGTC_514|Compound:4466-0038|FD-Score:6.76|P-value:1.05E-12 ID:SGTC_652|Compound:0437-0092|FD-Score:3.14|P-value:5.45E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:11.90|P-value:3.00E-35 ID:SGTC_665|Compound:3914-0008|FD-Score:3.76|P-value:4.46E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.57|P-value:1.02E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.04|P-value:1.32E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:3.70|P-value:5.87E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-6.08|P-value:1.43E-10 ID:SGTC_713|Compound:1488-1073|FD-Score:5.18|P-value:3.64E-8 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.12|P-value:6.18E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:5.36|P-value:1.23E-8 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.12|P-value:6.22E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:3.82|P-value:3.50E-5 ID:SGTC_917|Compound:harmaline|FD-Score:4.22|P-value:5.56E-6 ID:SGTC_918|Compound:glabranin|FD-Score:4.81|P-value:2.78E-7 ID:SGTC_935|Compound:2996-0153|FD-Score:3.13|P-value:5.51E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.33|P-value:2.79E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.64|P-value:7.59E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.01|P-value:9.29E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:2.97|P-value:9.87E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.13|P-value:6.03E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.02|P-value:8.22E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.92|P-value:2.21E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:4.31|P-value:3.71E-6 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.39|P-value:2.07E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.40|P-value:2.30E-6 ID:SGTC_1821|Compound:st053465|FD-Score:5.77|P-value:9.66E-10 ID:SGTC_1839|Compound:st053978|FD-Score:3.34|P-value:2.52E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.84|P-value:3.23E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.10|P-value:6.27E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.01|P-value:8.56E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.63|P-value:7.90E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.02|P-value:8.77E-4 ID:SGTC_2007|Compound:4011539|FD-Score:6.16|P-value:7.36E-11 ID:SGTC_2009|Compound:4012297|FD-Score:5.94|P-value:3.26E-10 ID:SGTC_2112|Compound:5488546|FD-Score:4.55|P-value:1.10E-6 ID:SGTC_2147|Compound:5545932|FD-Score:3.94|P-value:2.07E-5 ID:SGTC_2289|Compound:7946404|FD-Score:5.36|P-value:1.26E-8 ID:SGTC_2393|Compound:9031399|FD-Score:-3.35|P-value:2.58E-4 ID:SGTC_2399|Compound:5884133|FD-Score:7.11|P-value:7.08E-14 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.77|P-value:3.48E-7 ID:SGTC_2610|Compound:ononetin|FD-Score:4.12|P-value:9.06E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:4.14|P-value:8.01E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.44|P-value:1.87E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.18|P-value:3.56E-8 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.86|P-value:2.89E-5 ID:SGTC_2782|Compound:7736369|FD-Score:4.52|P-value:1.31E-6 ID:SGTC_2788|Compound:5282734|FD-Score:-3.77|P-value:4.72E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.39|P-value:2.22E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.43|P-value:1.79E-4 ID:SGTC_2833|Compound:9001315|FD-Score:5.16|P-value:4.05E-8 ID:SGTC_2954|Compound:9074818|FD-Score:3.97|P-value:1.76E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.26|P-value:3.74E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.10|P-value:6.58E-4 ID:SGTC_3101|Compound:9120531|FD-Score:5.37|P-value:1.16E-8 ID:SGTC_3122|Compound:9126309|FD-Score:3.43|P-value:1.79E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.73|P-value:5.04E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.96|P-value:1.84E-5 ID:SGTC_3350|Compound:9150499|FD-Score:3.70|P-value:5.79E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:19.00|P-value:8.92E-87 ID:SGTC_81|Compound:0411-0046|FD-Score:-3.08|P-value:7.26E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:5.59|P-value:2.99E-9 ID:SGTC_99|Compound:0109-0120|FD-Score:4.88|P-value:1.93E-7 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.27|P-value:3.60E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.51|P-value:1.29E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.62|P-value:2.94E-12 ID:SGTC_138|Compound:0850-0259|FD-Score:10.60|P-value:1.49E-28 ID:SGTC_514|Compound:4466-0038|FD-Score:6.76|P-value:1.05E-12 ID:SGTC_652|Compound:0437-0092|FD-Score:3.14|P-value:5.45E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:11.90|P-value:3.00E-35 ID:SGTC_665|Compound:3914-0008|FD-Score:3.76|P-value:4.46E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.57|P-value:1.02E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.04|P-value:1.32E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:3.70|P-value:5.87E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-6.08|P-value:1.43E-10 ID:SGTC_713|Compound:1488-1073|FD-Score:5.18|P-value:3.64E-8 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.12|P-value:6.18E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:5.36|P-value:1.23E-8 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.12|P-value:6.22E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:3.82|P-value:3.50E-5 ID:SGTC_917|Compound:harmaline|FD-Score:4.22|P-value:5.56E-6 ID:SGTC_918|Compound:glabranin|FD-Score:4.81|P-value:2.78E-7 ID:SGTC_935|Compound:2996-0153|FD-Score:3.13|P-value:5.51E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.33|P-value:2.79E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.64|P-value:7.59E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.01|P-value:9.29E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:2.97|P-value:9.87E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.13|P-value:6.03E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.02|P-value:8.22E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.92|P-value:2.21E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:4.31|P-value:3.71E-6 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.39|P-value:2.07E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.40|P-value:2.30E-6 ID:SGTC_1821|Compound:st053465|FD-Score:5.77|P-value:9.66E-10 ID:SGTC_1839|Compound:st053978|FD-Score:3.34|P-value:2.52E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.84|P-value:3.23E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.10|P-value:6.27E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.01|P-value:8.56E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.63|P-value:7.90E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.02|P-value:8.77E-4 ID:SGTC_2007|Compound:4011539|FD-Score:6.16|P-value:7.36E-11 ID:SGTC_2009|Compound:4012297|FD-Score:5.94|P-value:3.26E-10 ID:SGTC_2112|Compound:5488546|FD-Score:4.55|P-value:1.10E-6 ID:SGTC_2147|Compound:5545932|FD-Score:3.94|P-value:2.07E-5 ID:SGTC_2289|Compound:7946404|FD-Score:5.36|P-value:1.26E-8 ID:SGTC_2393|Compound:9031399|FD-Score:-3.35|P-value:2.58E-4 ID:SGTC_2399|Compound:5884133|FD-Score:7.11|P-value:7.08E-14 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.77|P-value:3.48E-7 ID:SGTC_2610|Compound:ononetin|FD-Score:4.12|P-value:9.06E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:4.14|P-value:8.01E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.44|P-value:1.87E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.18|P-value:3.56E-8 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.86|P-value:2.89E-5 ID:SGTC_2782|Compound:7736369|FD-Score:4.52|P-value:1.31E-6 ID:SGTC_2788|Compound:5282734|FD-Score:-3.77|P-value:4.72E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.39|P-value:2.22E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.43|P-value:1.79E-4 ID:SGTC_2833|Compound:9001315|FD-Score:5.16|P-value:4.05E-8 ID:SGTC_2954|Compound:9074818|FD-Score:3.97|P-value:1.76E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.26|P-value:3.74E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.10|P-value:6.58E-4 ID:SGTC_3101|Compound:9120531|FD-Score:5.37|P-value:1.16E-8 ID:SGTC_3122|Compound:9126309|FD-Score:3.43|P-value:1.79E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.73|P-value:5.04E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.96|P-value:1.84E-5 ID:SGTC_3350|Compound:9150499|FD-Score:3.70|P-value:5.79E-5

Top fitness defect scores for YKR042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 19.00 9.0 µM 8.92E-87 cell wall 15 1.50E-80
2 SGTC_663 1486-0733 11.90 13.9 µM 3.00E-35 cell wall signaling 9 8.79E-33
3 SGTC_138 0850-0259 10.60 40.9 µM 1.49E-28 cell wall 38 1.42E-26
4 SGTC_2399 5884133 7.11 200.0 µM 7.08E-14 cell wall signaling 20 5.75E-13
5 SGTC_514 4466-0038 6.76 2.6 nM 1.05E-12 cell wall 59 6.99E-12
6 SGTC_103 0844-0104 6.62 51.8 µM 2.94E-12 ERAD & cell cycle 64 1.82E-11
7 SGTC_2007 4011539 6.16 71.8 µM 7.36E-11 cell wall signaling 23 3.61E-10
8 SGTC_2009 4012297 5.94 12.1 µM 3.26E-10 cell wall signaling 23 1.43E-9
9 SGTC_1821 st053465 5.77 65.6 µM 9.66E-10 1 3.93E-9
10 SGTC_95 0471-0001 5.59 561.1 µM 2.99E-9 6 1.12E-8
11 SGTC_3101 9120531 5.37 49.5 µM 1.16E-8 10 3.95E-8
12 SGTC_835 0312-0010 5.36 67.2 µM 1.23E-8 2 4.18E-8
13 SGTC_2289 7946404 5.36 165.1 µM 1.26E-8 48 4.26E-8
14 SGTC_2689 tacrolimus 5.18 100.0 µM 3.56E-8 21 1.12E-7
15 SGTC_713 1488-1073 5.18 324.0 µM 3.64E-8 ERG2 10 1.14E-7
16 SGTC_2833 9001315 5.16 45.5 µM 4.05E-8 amide catabolism 28 1.26E-7
17 SGTC_99 0109-0120 4.88 622.8 µM 1.93E-7 3 5.35E-7
18 SGTC_918 glabranin 4.81 770.7 nM 2.78E-7 12 7.52E-7
19 SGTC_2405 ticlatone 4.77 3.5 µM 3.48E-7 42 9.26E-7
20 SGTC_2112 5488546 4.55 200.0 µM 1.10E-6 TSC3-RPN4 13 2.69E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.464 3.97E-179 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.444 2.75E-162 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.408 1.59E-134 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.387 3.34E-120 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.375 1.75E-112 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.359 2.05E-102 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.348 5.99E-96 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.312 1.49E-76 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.311 6.05E-76 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.305 2.27E-73 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.296 4.48E-69 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.296 1.03E-68 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.291 1.52E-66 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.290 3.38E-66 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.281 8.55E-62 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain