YKR047W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR047W / YKR047W

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.72|P-value:2.38E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.25|P-value:3.17E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:3.74|P-value:2.19E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:9.21|P-value:1.57E-18 ID:SGTC_358|Compound:0075-0058|FD-Score:5.67|P-value:4.50E-8 ID:SGTC_519|Compound:k048-0011|FD-Score:4.26|P-value:3.09E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.63|P-value:6.68E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:4.05|P-value:7.14E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.42|P-value:6.66E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.67|P-value:2.10E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.73|P-value:1.71E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.87|P-value:1.37E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.27|P-value:8.33E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.22|P-value:3.64E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-3.82|P-value:1.22E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.68|P-value:2.05E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.27|P-value:2.93E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.42|P-value:6.58E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.81|P-value:1.73E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.31|P-value:9.49E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.97|P-value:1.44E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.68|P-value:2.79E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.24|P-value:3.31E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.60|P-value:3.57E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.55|P-value:4.34E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.84|P-value:1.55E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.84|P-value:1.53E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.69|P-value:2.62E-4 ID:SGTC_1775|Compound:st081588|FD-Score:4.19|P-value:4.03E-5 ID:SGTC_1804|Compound:st050076|FD-Score:5.14|P-value:6.50E-7 ID:SGTC_1805|Compound:st050013|FD-Score:5.20|P-value:4.89E-7 ID:SGTC_1896|Compound:st058441|FD-Score:4.22|P-value:3.58E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-5.24|P-value:2.56E-7 ID:SGTC_1950|Compound:st077106|FD-Score:-4.45|P-value:9.83E-6 ID:SGTC_1968|Compound:st069590|FD-Score:3.72|P-value:2.40E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.55|P-value:4.26E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.86|P-value:1.43E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.40|P-value:7.06E-4 ID:SGTC_2146|Compound:5545642|FD-Score:5.43|P-value:1.58E-7 ID:SGTC_2155|Compound:5570423|FD-Score:-4.08|P-value:4.42E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.51|P-value:4.98E-4 ID:SGTC_2353|Compound:9059630|FD-Score:4.47|P-value:1.32E-5 ID:SGTC_2362|Compound:9071156|FD-Score:-3.56|P-value:3.14E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.99|P-value:1.27E-6 ID:SGTC_2516|Compound:gossypol|FD-Score:3.31|P-value:9.57E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.17|P-value:3.74E-7 ID:SGTC_2585|Compound:alliin|FD-Score:3.90|P-value:1.25E-4 ID:SGTC_2784|Compound:7567673|FD-Score:5.10|P-value:7.77E-7 ID:SGTC_2848|Compound:9016370|FD-Score:5.61|P-value:6.28E-8 ID:SGTC_2851|Compound:9015922|FD-Score:10.70|P-value:2.75E-24 ID:SGTC_2903|Compound:5923464|FD-Score:3.35|P-value:8.45E-4 ID:SGTC_2921|Compound:7974240|FD-Score:5.53|P-value:9.20E-8 ID:SGTC_3058|Compound:9093861|FD-Score:3.56|P-value:4.23E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.79|P-value:1.84E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.51|P-value:4.90E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.62|P-value:3.44E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.72|P-value:2.38E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.25|P-value:3.17E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:3.74|P-value:2.19E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:9.21|P-value:1.57E-18 ID:SGTC_358|Compound:0075-0058|FD-Score:5.67|P-value:4.50E-8 ID:SGTC_519|Compound:k048-0011|FD-Score:4.26|P-value:3.09E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.63|P-value:6.68E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:4.05|P-value:7.14E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.42|P-value:6.66E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.67|P-value:2.10E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.73|P-value:1.71E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.87|P-value:1.37E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.27|P-value:8.33E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.22|P-value:3.64E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-3.82|P-value:1.22E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.68|P-value:2.05E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.27|P-value:2.93E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.42|P-value:6.58E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.81|P-value:1.73E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.31|P-value:9.49E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.97|P-value:1.44E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.68|P-value:2.79E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.24|P-value:3.31E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.60|P-value:3.57E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.55|P-value:4.34E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.84|P-value:1.55E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.84|P-value:1.53E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.69|P-value:2.62E-4 ID:SGTC_1775|Compound:st081588|FD-Score:4.19|P-value:4.03E-5 ID:SGTC_1804|Compound:st050076|FD-Score:5.14|P-value:6.50E-7 ID:SGTC_1805|Compound:st050013|FD-Score:5.20|P-value:4.89E-7 ID:SGTC_1896|Compound:st058441|FD-Score:4.22|P-value:3.58E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-5.24|P-value:2.56E-7 ID:SGTC_1950|Compound:st077106|FD-Score:-4.45|P-value:9.83E-6 ID:SGTC_1968|Compound:st069590|FD-Score:3.72|P-value:2.40E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.55|P-value:4.26E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.86|P-value:1.43E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.40|P-value:7.06E-4 ID:SGTC_2146|Compound:5545642|FD-Score:5.43|P-value:1.58E-7 ID:SGTC_2155|Compound:5570423|FD-Score:-4.08|P-value:4.42E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.51|P-value:4.98E-4 ID:SGTC_2353|Compound:9059630|FD-Score:4.47|P-value:1.32E-5 ID:SGTC_2362|Compound:9071156|FD-Score:-3.56|P-value:3.14E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.99|P-value:1.27E-6 ID:SGTC_2516|Compound:gossypol|FD-Score:3.31|P-value:9.57E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.17|P-value:3.74E-7 ID:SGTC_2585|Compound:alliin|FD-Score:3.90|P-value:1.25E-4 ID:SGTC_2784|Compound:7567673|FD-Score:5.10|P-value:7.77E-7 ID:SGTC_2848|Compound:9016370|FD-Score:5.61|P-value:6.28E-8 ID:SGTC_2851|Compound:9015922|FD-Score:10.70|P-value:2.75E-24 ID:SGTC_2903|Compound:5923464|FD-Score:3.35|P-value:8.45E-4 ID:SGTC_2921|Compound:7974240|FD-Score:5.53|P-value:9.20E-8 ID:SGTC_3058|Compound:9093861|FD-Score:3.56|P-value:4.23E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.79|P-value:1.84E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.51|P-value:4.90E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.62|P-value:3.44E-4

Top fitness defect scores for YKR047W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2851 9015922 10.70 71.4 µM 2.75E-24 1 6.73E-27
2 SGTC_160 3453-0671 9.21 289.7 µM 1.57E-18 3 1.68E-20
3 SGTC_358 0075-0058 5.67 9.4 µM 4.50E-8 21 7.17E-9
4 SGTC_2848 9016370 5.61 26.0 µM 6.28E-8 4 1.04E-8
5 SGTC_2921 7974240 5.53 10.7 µM 9.20E-8 18 1.59E-8
6 SGTC_2146 5545642 5.43 200.0 µM 1.58E-7 3 2.89E-8
7 SGTC_1805 st050013 5.20 60.3 µM 4.89E-7 2 1.02E-7
8 SGTC_1804 st050076 5.14 49.1 µM 6.50E-7 3 1.40E-7
9 SGTC_2784 7567673 5.10 72.7 µM 7.77E-7 iron homeostasis 13 1.71E-7
10 SGTC_2365 9042475 4.99 200.0 µM 1.27E-6 16 2.95E-7
11 SGTC_1268 0828-0275 4.97 2.5 µM 1.44E-6 6 3.40E-7
12 SGTC_572 0960-0087 4.63 17.7 µM 6.68E-6 16 1.87E-6
13 SGTC_2353 9059630 4.47 146.7 µM 1.32E-5 16 3.97E-6
14 SGTC_1038 k292-0204 4.27 154.0 µM 2.93E-5 12 9.69E-6
15 SGTC_519 k048-0011 4.26 62.8 µM 3.09E-5 13 1.03E-5
16 SGTC_95 0471-0001 4.25 561.1 µM 3.17E-5 20 1.06E-5
17 SGTC_1317 1273-0028 4.24 910.0 nM 3.31E-5 azole & statin 42 1.11E-5
18 SGTC_1896 st058441 4.22 89.0 µM 3.58E-5 9 1.21E-5
19 SGTC_914 3820-6779 4.22 408.0 µM 3.64E-5 16 1.23E-5
20 SGTC_1775 st081588 4.19 35.2 µM 4.03E-5 60S ribosome export 20 1.38E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.58E-11 YLR131C ACE2 hom Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
0.112 7.50E-11 YKL054C DEF1 hom RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis
0.085 9.07E-7 YJL108C PRM10 hom Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.081 2.98E-6 YDR273W DON1 hom Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
0.080 3.39E-6 YPR046W MCM16 hom Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3
0.080 3.82E-6 YHR007C-A_p YHR007C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.079 4.28E-6 YNL175C NOP13 hom Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress
0.079 4.69E-6 YKL048C ELM1 hom Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
0.078 5.39E-6 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.076 1.16E-5 YFL045C SEC53 het Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
0.076 1.16E-5 YOR348C PUT4 hom Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
0.075 1.29E-5 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.074 1.74E-5 YHR198C AIM18 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.074 1.80E-5 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.073 2.22E-5 YHL007C STE20 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p