YKR054C / DYN1

Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR054C / DYN1

Click on Significant Values for Screen Details ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.02|P-value:7.41E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.91|P-value:2.12E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:2.99|P-value:8.08E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.99|P-value:1.50E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.95|P-value:3.86E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.58|P-value:1.76E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.73|P-value:9.69E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:-4.41|P-value:4.85E-6 ID:SGTC_727|Compound:3032-0951|FD-Score:2.93|P-value:9.95E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:2.98|P-value:8.48E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:5.33|P-value:1.50E-8 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.82|P-value:6.58E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.67|P-value:1.23E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.59|P-value:8.42E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.72|P-value:4.32E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.06|P-value:1.08E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.61|P-value:1.53E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.85|P-value:2.83E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.46|P-value:1.39E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.94|P-value:3.27E-7 ID:SGTC_1948|Compound:st076329|FD-Score:4.82|P-value:2.49E-7 ID:SGTC_2298|Compound:7976326|FD-Score:2.99|P-value:8.21E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-3.30|P-value:4.95E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.08|P-value:5.98E-4 ID:SGTC_2324|Compound:6149169|FD-Score:2.99|P-value:8.08E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.00|P-value:7.87E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.14|P-value:4.78E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.69|P-value:5.48E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.20|P-value:3.86E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.02|P-value:7.41E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.91|P-value:2.12E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:2.99|P-value:8.08E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.99|P-value:1.50E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.95|P-value:3.86E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.58|P-value:1.76E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.73|P-value:9.69E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:-4.41|P-value:4.85E-6 ID:SGTC_727|Compound:3032-0951|FD-Score:2.93|P-value:9.95E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:2.98|P-value:8.48E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:5.33|P-value:1.50E-8 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.82|P-value:6.58E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.67|P-value:1.23E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.59|P-value:8.42E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.72|P-value:4.32E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.06|P-value:1.08E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.61|P-value:1.53E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.85|P-value:2.83E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.46|P-value:1.39E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.94|P-value:3.27E-7 ID:SGTC_1948|Compound:st076329|FD-Score:4.82|P-value:2.49E-7 ID:SGTC_2298|Compound:7976326|FD-Score:2.99|P-value:8.21E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-3.30|P-value:4.95E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.08|P-value:5.98E-4 ID:SGTC_2324|Compound:6149169|FD-Score:2.99|P-value:8.08E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.00|P-value:7.87E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.14|P-value:4.78E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.69|P-value:5.48E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.20|P-value:3.86E-4

Top fitness defect scores for YKR054C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_773 4358-1457 5.33 44.6 µM 1.50E-8 16 5.03E-8
2 SGTC_1948 st076329 4.82 66.6 µM 2.49E-7 11 7.05E-7
3 SGTC_1251 0490-5699 4.72 265.0 µM 4.32E-7 16 1.18E-6
4 SGTC_1248 0469-0687 4.59 58.6 µM 8.42E-7 14 2.22E-6
5 SGTC_1445 4239-0156 4.06 97.7 µM 1.08E-5 25 2.43E-5
6 SGTC_649 1123-0311 3.99 367.0 µM 1.50E-5 endomembrane recycling 66 3.31E-5
7 SGTC_185 k048-0037 3.91 25.5 µM 2.12E-5 RSC & ERG11 11 4.58E-5
8 SGTC_1861 st057647 3.85 17.4 µM 2.83E-5 23 5.99E-5
9 SGTC_2967 9089538 3.69 49.9 µM 5.48E-5 43 1.11E-4
10 SGTC_1871 st057448 3.46 67.3 µM 1.39E-4 41 2.66E-4
11 SGTC_3314 9135860 3.20 59.4 µM 3.86E-4 44 6.92E-4
12 SGTC_2919 7978188 3.14 46.4 µM 4.78E-4 54 8.45E-4
13 SGTC_2318 6029776 3.08 164.0 µM 5.98E-4 72 0.00104
14 SGTC_102 gallobenzophenone 3.02 83.6 µM 7.41E-4 redox potentiating 78 0.00127
15 SGTC_2335 9018011 3.00 154.2 µM 7.87E-4 72 0.00135
16 SGTC_2324 6149169 2.99 200.0 µM 8.08E-4 48 0.00138
17 SGTC_199 4063-0024 2.99 41.6 µM 8.08E-4 25 0.00138
18 SGTC_2298 7976326 2.99 193.8 µM 8.21E-4 31 0.00140
19 SGTC_763 3453-1109 2.98 128.0 µM 8.48E-4 55 0.00144
20 SGTC_727 3032-0951 2.93 202.0 µM 9.95E-4 79 0.00168

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.211 4.31E-35 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.158 3.16E-20 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.151 1.81E-18 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.126 2.58E-13 YGL220W FRA2 hom Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
0.125 3.47E-13 YOR003W YSP3 hom Putative precursor to the subtilisin-like protease III
0.120 2.87E-12 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.114 3.26E-11 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114 3.47E-11 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.114 3.92E-11 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.112 8.97E-11 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.111 1.04E-10 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.109 2.20E-10 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.102 2.62E-9 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.102 2.91E-9 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.102 3.79E-9 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1