HIPHOP chemogenomics database

YKR054C / DYN1

Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p

Zygosity: Homozygous strain

fixedexpanded
Profile for YKR054C / DYN1

Click on Significant Values for Screen Details

Top fitness defect scores for YKR054C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_773	4358-1457	5.33	44.6 µM	1.50E-8		16	5.03E-8
2	SGTC_1948	st076329	4.82	66.6 µM	2.49E-7		11	7.05E-7
3	SGTC_1251	0490-5699	4.72	265.0 µM	4.32E-7		16	1.18E-6
4	SGTC_1248	0469-0687	4.59	58.6 µM	8.42E-7		14	2.22E-6
5	SGTC_1445	4239-0156	4.06	97.7 µM	1.08E-5		25	2.43E-5
6	SGTC_649	1123-0311	3.99	367.0 µM	1.50E-5	endomembrane recycling	66	3.31E-5
7	SGTC_185	k048-0037	3.91	25.5 µM	2.12E-5	RSC & ERG11	11	4.58E-5
8	SGTC_1861	st057647	3.85	17.4 µM	2.83E-5		23	5.99E-5
9	SGTC_2967	9089538	3.69	49.9 µM	5.48E-5		43	1.11E-4
10	SGTC_1871	st057448	3.46	67.3 µM	1.39E-4		41	2.66E-4
11	SGTC_3314	9135860	3.20	59.4 µM	3.86E-4		44	6.92E-4
12	SGTC_2919	7978188	3.14	46.4 µM	4.78E-4		54	8.45E-4
13	SGTC_2318	6029776	3.08	164.0 µM	5.98E-4		72	0.00104
14	SGTC_102	gallobenzophenone	3.02	83.6 µM	7.41E-4	redox potentiating	78	0.00127
15	SGTC_2335	9018011	3.00	154.2 µM	7.87E-4		72	0.00135
16	SGTC_2324	6149169	2.99	200.0 µM	8.08E-4		48	0.00138
17	SGTC_199	4063-0024	2.99	41.6 µM	8.08E-4		25	0.00138
18	SGTC_2298	7976326	2.99	193.8 µM	8.21E-4		31	0.00140
19	SGTC_763	3453-1109	2.98	128.0 µM	8.48E-4		55	0.00144
20	SGTC_727	3032-0951	2.93	202.0 µM	9.95E-4		79	0.00168

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.211	4.31E-35	YDR210W_p	YDR210W_p	hom	Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.158	3.16E-20	YAL043C	PTA1	het	Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.151	1.81E-18	YBL009W	ALK2	hom	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.126	2.58E-13	YGL220W	FRA2	hom	Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
0.125	3.47E-13	YOR003W	YSP3	hom	Putative precursor to the subtilisin-like protease III
0.120	2.87E-12	YOR238W_p	YOR238W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.114	3.26E-11	YGR025W_d	YGR025W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114	3.47E-11	YKL117W	SBA1	hom	Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.114	3.92E-11	YDR122W	KIN1	hom	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.112	8.97E-11	YLR053C_p	YLR053C_p	hom	Putative protein of unknown function
0.111	1.04E-10	YJR041C	URB2	het	Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.109	2.20E-10	YKL067W	YNK1	hom	Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.102	2.62E-9	YJL068C	YJL068C	hom	Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.102	2.91E-9	YCL026C-A	FRM2	hom	Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.102	3.79E-9	YDR055W	PST1	hom	Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1