YKR057W / RPS21A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR057W / RPS21A

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.64|P-value:2.82E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.42|P-value:8.53E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.52|P-value:6.17E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.53|P-value:4.15E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.83|P-value:2.17E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.54|P-value:4.02E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.46|P-value:5.29E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.44|P-value:5.66E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.19|P-value:3.69E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-4.00|P-value:1.16E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.89|P-value:2.04E-6 ID:SGTC_677|Compound:0929-0063|FD-Score:3.36|P-value:7.25E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.86|P-value:1.33E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.21|P-value:4.46E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:8.75|P-value:1.14E-16 ID:SGTC_736|Compound:0958-0254|FD-Score:3.35|P-value:7.59E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.97|P-value:8.72E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:5.11|P-value:7.26E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:8.49|P-value:7.91E-16 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.05|P-value:6.49E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.70|P-value:2.34E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.58|P-value:3.52E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.65|P-value:2.79E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.40|P-value:6.27E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.50|P-value:4.65E-4 ID:SGTC_1753|Compound:st043925|FD-Score:-4.69|P-value:7.80E-6 ID:SGTC_1755|Compound:st041960|FD-Score:5.81|P-value:2.29E-8 ID:SGTC_1764|Compound:st044502|FD-Score:-3.54|P-value:5.84E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.57|P-value:3.61E-4 ID:SGTC_1811|Compound:st050069|FD-Score:-3.62|P-value:4.48E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-4.17|P-value:6.16E-5 ID:SGTC_1839|Compound:st053978|FD-Score:5.35|P-value:2.35E-7 ID:SGTC_1847|Compound:st056231|FD-Score:3.31|P-value:8.61E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.46|P-value:7.62E-4 ID:SGTC_2265|Compound:7929201|FD-Score:5.07|P-value:8.69E-7 ID:SGTC_2329|Compound:6138490|FD-Score:4.06|P-value:6.18E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.24|P-value:3.09E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.27|P-value:3.36E-7 ID:SGTC_2931|Compound:9014674|FD-Score:3.97|P-value:8.83E-5 ID:SGTC_2941|Compound:9056145|FD-Score:-3.72|P-value:3.22E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.26|P-value:9.88E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.05|P-value:9.97E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.56|P-value:3.68E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.64|P-value:2.82E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.42|P-value:8.53E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.52|P-value:6.17E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.53|P-value:4.15E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.83|P-value:2.17E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.54|P-value:4.02E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.46|P-value:5.29E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.44|P-value:5.66E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.19|P-value:3.69E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-4.00|P-value:1.16E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.89|P-value:2.04E-6 ID:SGTC_677|Compound:0929-0063|FD-Score:3.36|P-value:7.25E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.86|P-value:1.33E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.21|P-value:4.46E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:8.75|P-value:1.14E-16 ID:SGTC_736|Compound:0958-0254|FD-Score:3.35|P-value:7.59E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.97|P-value:8.72E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:5.11|P-value:7.26E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:8.49|P-value:7.91E-16 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.05|P-value:6.49E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.70|P-value:2.34E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.58|P-value:3.52E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.65|P-value:2.79E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.40|P-value:6.27E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.50|P-value:4.65E-4 ID:SGTC_1753|Compound:st043925|FD-Score:-4.69|P-value:7.80E-6 ID:SGTC_1755|Compound:st041960|FD-Score:5.81|P-value:2.29E-8 ID:SGTC_1764|Compound:st044502|FD-Score:-3.54|P-value:5.84E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.57|P-value:3.61E-4 ID:SGTC_1811|Compound:st050069|FD-Score:-3.62|P-value:4.48E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-4.17|P-value:6.16E-5 ID:SGTC_1839|Compound:st053978|FD-Score:5.35|P-value:2.35E-7 ID:SGTC_1847|Compound:st056231|FD-Score:3.31|P-value:8.61E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.46|P-value:7.62E-4 ID:SGTC_2265|Compound:7929201|FD-Score:5.07|P-value:8.69E-7 ID:SGTC_2329|Compound:6138490|FD-Score:4.06|P-value:6.18E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.24|P-value:3.09E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.27|P-value:3.36E-7 ID:SGTC_2931|Compound:9014674|FD-Score:3.97|P-value:8.83E-5 ID:SGTC_2941|Compound:9056145|FD-Score:-3.72|P-value:3.22E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.26|P-value:9.88E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.05|P-value:9.97E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.56|P-value:3.68E-4

Top fitness defect scores for YKR057W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_708 3448-5400 8.75 146.0 µM 1.14E-16 3 1.10E-18
2 SGTC_1107 amlodipine 8.49 47.0 µM 7.91E-16 1 1.01E-17
3 SGTC_1755 st041960 5.81 45.2 µM 2.29E-8 5 3.17E-9
4 SGTC_1839 st053978 5.35 48.0 µM 2.35E-7 4 4.45E-8
5 SGTC_2688 kanamycin b 5.27 96.7 µM 3.36E-7 calcium & mitochondrial duress 223 6.69E-8
6 SGTC_691 1548-0686 5.21 185.0 µM 4.46E-7 10 9.21E-8
7 SGTC_877 0771-0151 5.11 33.1 µM 7.26E-7 5 1.60E-7
8 SGTC_2265 7929201 5.07 200.0 µM 8.69E-7 7 1.96E-7
9 SGTC_673 1082-0474 4.89 110.0 µM 2.04E-6 RSC complex & mRNA processing 38 5.15E-7
10 SGTC_2512 diallyl trisulfide 4.24 49.2 µM 3.09E-5 4 1.11E-5
11 SGTC_625 k213-0058 4.19 121.0 µM 3.69E-5 translation 91 1.37E-5
12 SGTC_2329 6138490 4.06 200.0 µM 6.18E-5 29 2.44E-5
13 SGTC_1180 1193-0155 4.05 285.0 µM 6.49E-5 13 2.58E-5
14 SGTC_800 3448-7362 3.97 155.0 µM 8.72E-5 translation 161 3.60E-5
15 SGTC_2931 9014674 3.97 55.7 µM 8.83E-5 21 3.65E-5
16 SGTC_679 0422-0091 3.86 41.4 µM 1.33E-4 Golgi 31 5.78E-5
17 SGTC_1199 1638-0010 3.70 4.5 µM 2.34E-4 endomembrane recycling 37 1.10E-4
18 SGTC_1378 2093-0007 3.65 380.0 nM 2.79E-4 28 1.33E-4
19 SGTC_37 0566-0070 3.64 1.6 µM 2.82E-4 38 1.35E-4
20 SGTC_1374 2889-5571 3.58 141.0 µM 3.52E-4 RSC complex & mRNA processing 56 1.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 4.45E-31 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.168 1.25E-22 YMR143W RPS16A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication
0.166 3.60E-22 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.155 1.75E-19 YHR034C PIH1 hom Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
0.153 6.40E-19 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.146 1.56E-17 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.143 7.30E-17 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.141 2.05E-16 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.139 5.81E-16 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.134 7.42E-15 YKL143W LTV1 hom Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
0.132 1.70E-14 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.130 4.46E-14 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.129 8.22E-14 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.127 1.64E-13 YLR322W_d VPS65_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth
0.123 7.36E-13 YNL096C RPS7B hom Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress